Ivermectin injection and preparation method thereof

A technology of ivermectin and injection, which can be applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of simple administration, improved product quality and bioavailability, and less irritation.

Pending Publication Date: 2021-11-16
哈尔滨绿达生动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, most of the existing ivermectin sustained-release agents are single drug species, which not only limits the application of the drug, but also has a narrow insecticidal spectrum of a single drug, which easily produces drug resistance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] An ivermectin injection, comprising the following components in parts by weight: 0.2-0.6 part of ivermectin, 0.1-0.3 part of monepal, 0.2-0.6 part of albendazole sulfoxide hydrochloride , 0.02-0.07 parts of suspending agent, 0.08-0.1 part of emulsifier, 10-16 parts of propylene glycol, 2-4 parts of ethyl cellulose, 4-8 parts of ethyl oleate, 0.2-0.4 parts of nonionic surfactant.

[0019] Wherein, the suspending agent is selected from methylcellulose, Pluronic F-68, carboxymethylcellulose, sodium alginate, aluminum monostearate, silicone oil, polyvinylpyrrolidone, gelatin, mannitol, sorbitol One or more of them; the emulsifier is selected from one or more of polysorbate-80, lecithin, soybean lecithin, polyoxyethylene castor oil, calcium dodecylbenzenesulfonate; the non- The ionic surfactant is Tween-80, Tween-60 or Tween-40.

[0020] Example 1

[0021] An ivermectin injection, comprising the following components in parts by weight: 0.2-0.6 part of ivermectin, 0.1-0.3 p...

Embodiment 2

[0024] An ivermectin injection comprising the following components in parts by weight: 0.2 part of ivermectin, 0.1 part of monepal, 0.6 part of albendazole sulfoxide hydrochloride, 0.02 part of suspending agent , 0.08 parts of emulsifier, 10 parts of propylene glycol, 2 parts of ethyl cellulose, 4 parts of ethyl oleate, 0.2 parts of nonionic surfactant.

[0025] Wherein, the suspending agent is selected from methylcellulose, Pluronic F-68, carboxymethylcellulose, sodium alginate, aluminum monostearate, silicone oil, polyvinylpyrrolidone, gelatin, mannitol, sorbitol One or more of them; the emulsifier is selected from one or more of polysorbate-80, lecithin, soybean lecithin, polyoxyethylene castor oil, calcium dodecylbenzenesulfonate; the non- The ionic surfactant is Tween-80, Tween-60 or Tween-40.

Embodiment 3

[0027] An ivermectin injection comprising the following components in parts by weight: 0.4 part of ivermectin, 0.2 part of monepal, 0.24 part of albendazole sulfoxide hydrochloride, 0.05 part of suspending agent , 0.09 parts of emulsifier, 12 parts of propylene glycol, 23 parts of ethyl cellulose, 46 parts of ethyl oleate, 0.3 parts of nonionic surfactant.

[0028] Wherein, the suspending agent is selected from methylcellulose, Pluronic F-68, carboxymethylcellulose, sodium alginate, aluminum monostearate, silicone oil, polyvinylpyrrolidone, gelatin, mannitol, sorbitol One or more of them; the emulsifier is selected from one or more of polysorbate-80, lecithin, soybean lecithin, polyoxyethylene castor oil, calcium dodecylbenzenesulfonate; the non- The ionic surfactant is Tween-80, Tween-60 or Tween-40.

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PUM

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Abstract

The invention discloses an ivermectin injection and a preparation method thereof. The ivermectin injection is prepared from ivermectin, monepantel, albendazole sulfoxide hydrochloride, a suspending aid, an emulsifier, propylene glycol, ethyl cellulose, ethyl oleate and a nonionic surfactant. According to product, ivermectin, monepantel and albendazole sulfoxide hydrochloride are adopted as effective insecticidal components, through optimization of carrier solvent, propylene glycol and glycerol methylal are used as solvent and cosolvent, ethyl oleate is used as slow release agent, product quality and bioavailability can be well improved, and insect repelling effect is remarkable. In addition, the composition is beneficial to maintaining the drug activity and promoting the mutual synergistic effect of the drugs, so that the insecticidal spectrum is expanded, the insecticidal effect is improved, and the generation of drug resistance can be effectively delayed.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to an ivermectin injection and a preparation method thereof. Background technique [0002] Ivermectin is a new type of broad-spectrum, high-efficiency, and low-toxic antibiotic antiparasitic drug. It has good repellent effects on internal and external parasites, especially nematodes and arthropods. It is effective against larvae, and it is also effective against faecal garden filariae that are only in the intestinal tract. Ivermectin is widely used clinically, and the blood drug peaks in 2-4 hours after oral administration to livestock and poultry. However, because the bioavailability of oral administration is only 41% of that of injection, this limits the wide application of oral preparations. Although the ivermectin injection has been developed now, different solvents are used in the preparation, so that there are different problems in product quality. Studies in recen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4184A61K31/277A61K9/08A61K47/10A61K47/38A61K47/36A61K47/12A61K47/34A61K47/32A61K47/42A61K47/26A61K47/24A61K47/44A61K47/20A61P33/14A61P33/10A61P33/00
CPCA61K31/7048A61K31/4184A61K31/277A61K9/08A61K9/0019A61K47/10A61K47/38A61K47/36A61K47/12A61K47/34A61K47/32A61K47/42A61K47/26A61K47/24A61K47/44A61K47/20A61P33/14A61P33/10A61P33/00A61K2300/00
Inventor 崔赢予井旭东唐伟苏景徐丽郝敬友杨宁张宇田梁文静张萍
Owner 哈尔滨绿达生动物药业有限公司
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