Liquid crystal state composite fiber membrane as well as preparation and application thereof

A technology of composite fiber membrane and liquid crystal state, which can be used in prosthetics, drug delivery, textiles and paper making, and can solve problems such as biocompatibility gaps

Active Publication Date: 2021-11-23
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current research, although PU has excellent mechanical properties, there is still a certain gap between its biocompatibility and ideal biomaterials.

Method used

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  • Liquid crystal state composite fiber membrane as well as preparation and application thereof
  • Liquid crystal state composite fiber membrane as well as preparation and application thereof
  • Liquid crystal state composite fiber membrane as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] The preparation of embodiment 1LC / PU liquid crystal composite fiber film

[0059] (1) Preparation of CN-COC binary blend liquid crystal (LC):

[0060] CN and COC are respectively 0:100, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10, 100 according to the mass ratio :0 Blending. Add the mixture into the glass tube, then place the glass tube in an oven, adjust the temperature to 95°C and maintain it for 3 minutes, at this time, both liquid crystal compounds reach the clearing point, then fully stir until the two liquid crystals are completely mixed, and cool into powder Samples were stored in a dry box for later use.

[0061] (2) Preparation of liquid crystal composite fiber membrane:

[0062] Accurately weigh the CN-COC binary co-liquid crystal (LC) prepared by CN and COC in (1) according to the mass ratio of 30:70, add it into dichloromethane, stir at a speed of 100r / min until completely dissolved, and obtain LC / Dichloromethane solution; according to...

Embodiment 2

[0066] Performance analysis of embodiment 2LC / PU liquid crystal composite fiber membrane

[0067] ① Weigh about 6-10 mg of dry CN-COC and LC / PU composite film, seal the aluminum crucible, put it into a differential scanning calorimeter, and raise the temperature from -20°C to 100°C at a rate of 5°C / min ℃, keep the temperature for 5min, cool down to -20℃, and heat up again, then drop to room temperature, the whole test process is under N 2 under protection. Observe and record the temperature during the change process of the liquid crystal composite film and take pictures. With the increase of the CN content, the liquid crystal phase temperature range of the CN-COC blended liquid crystal moves to a higher place. With the increase of the LC content in the LC / PU hybrid film, the mixed The liquid crystallinity of the film is more remarkable, and the liquid crystal phase interval also shifts to a higher position.

[0068] ② Place the CN-COC and LC / PU composite film on the inner gl...

Embodiment 3

[0070] Example 3 Preparation of Biomimetic Mineralized LC / PU Liquid Crystal Composite Fiber Membrane

[0071] The CN and COC were blended at a mass ratio of 30:70. Add the mixture into the glass tube, then place the glass tube in an oven, adjust the temperature to 95°C and maintain it for 3 minutes, at this time, both liquid crystal compounds reach the clearing point, then fully stir until the two liquid crystals are completely mixed, and cool into powder sample. Then add it into dichloromethane, stir until completely dissolved at a speed of 100r / min, and obtain LC / dichloromethane solution; according to the mass ratio of LC and PU of 40:60, accurately weigh PU and add it to the obtained LC / dichloromethane In the solution (wherein, the total concentration of PU is 8%), the mixture is continuously stirred until the solute is completely dissolved to obtain a LC / PU mixed solution.

[0072] Introduce the fully dissolved LC / PU mixed solution into the micro-syringe pump, select the...

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Abstract

The invention discloses a liquid crystal state composite fiber membrane as well as preparation and application thereof. The method comprises the following steps of mixing cholesteryl nonanoate and cholesteryl oleyl carbonate according to a formula ratio, heating until the temperatures of the two liquid crystal compounds reach the clearing point temperature or above, fully stirring until the two liquid crystal compounds are fully mixed, and cooling to obtain powder, so as to obtain CN-COC binary blended liquid crystal; and then adding the liquid crystal and a polyurethane elastomer into dichloromethane according to a formula ratio, stirring a mixture until solutes are completely dissolved, and obtaining the composite fiber membrane through an electrostatic spinning technology. The liquid crystal state composite membrane not only has liquid crystal state ordered fluidity and good biological performance, but also has the elastic characteristic of polyurethane, has good biological performance and mechanical performance, and can be used for constructing a biological membrane model imitating the extracellular matrix of the living body, and the influence of the liquid crystal performance of the living body on cell behaviors is researched on the basis, so that theoretical and technical supports are provided for ascertaining the interaction between the cells and the matrixes in the microenvironment of the living body.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to a liquid crystal composite fiber membrane and its preparation and application. Background technique [0002] The liquid crystal state has both the fluidity of a liquid and the orderliness of a solid. It is a state of matter between liquid and solid. In biological systems, the combination of order and fluidity is the basis for the formation of tissues and structures, so liquid crystals play a very important role in biology. The four major compounds that make up living organisms, lipids, proteins, nucleic acids, and polysaccharides, all have liquid crystal structures. Without liquid crystal structures, many functions of life systems cannot function normally. A large number of studies have also shown that liquid crystals are closely related to biological structures. For example, nerve cell sphingomyelin solution has the polarizing properties of liquid crystals, muscle ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4358A61L27/18A61L27/50
CPCD04H1/728D04H1/4358A61L27/18A61L27/50D10B2509/06D10B2509/00A61L2430/02A61L2400/16C08L75/08Y02W10/10
Inventor 李娜李霞艾毅龙黄达鸿
Owner FOSHAN UNIVERSITY
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