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Application of composition of enterococcus and berberine in treatment of phenylketonuria

A technology for phenylketonuria and enterococci, applied in the field of medicine, can solve problems such as reducing phenylalanine, achieve the effect of reducing phenylalanine content, reducing acquisition, and improving phenylketonuria

Pending Publication Date: 2021-11-26
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the treatment methods are to reduce the content of phenylalanine in the diet such as breast milk or infant formula, and there is no clinically available preventive / curable drug

Method used

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  • Application of composition of enterococcus and berberine in treatment of phenylketonuria
  • Application of composition of enterococcus and berberine in treatment of phenylketonuria
  • Application of composition of enterococcus and berberine in treatment of phenylketonuria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1. Experimental Experiment of Swynamoblococcusceralatine Body Transformation

[0026] The concentration of phenylalanine in in vitro culture system is one of the important indicators of evaluating the degradation of benzophenionate capabilities in Swyntleus.

[0027] 1, experimental strains, instruments and reagents

[0028] Phenylalanine is purchased from Beijing Solabao Technology Company. Entreococcus Faeccus Faecalis (ATCC47077) from ATCC, MRS medium from Solabao.

[0029] 2, experimental instrument and analysis method

[0030] High-performance liquid chromatography - triple four-stage string joint syrupted spectroscopy (LC-MS / MS 8050, Japanese Shimadz Company), quantitatively determined phenylanine content in blood. Determination of benzlanine using alltima c 18 (5 μM, 4.6 x150 mm) column, the column temperature was 40 ° C. The mobile phase is water-formic acid (100: 0.1V / V) and methanol. Elution of gradient (A: B, 0min, 90: 10; 1 min, 90: 10; 1.01min, 60: ...

Embodiment 2

[0037] Example 2. Therapeutic effects of Swyncus and the use of berberine induced by α-methylbenzophenine induced by α-methylbenzophenine.

[0038] The concentration of phenylalanine in blood is one of the important indicators of evaluating the therapeutic effect of benzenzone urine SD mouse.

[0039] 1, experimental animals, instruments and drug reagents

[0040] SD mouse (1 day age) purchased from Beijing Virong Lihua Electrical Co., Ltd., animal and mouse were shared in SPF (21 ± 2 ° C, 12 hours of photos cycle), free diet and drinking water during experiment . Phenylalanine is purchased from Beijing Solabao Technology Company. α-methyllatine purchases from Nanjing Snowkai. Swifts (ATCC47077) from the ATCC strain, obtained from this laboratory and amplification, berberine is purchased from Balance.

[0041] 2, experimental instrument and analysis method

[0042] High-performance liquid chromatography - triple four-stage string joint syrupted spectroscopy (LC-MS / MS 8050, Japan...

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Abstract

The invention relates to the technical field of medicines, and provides application of a composition of enterococcus and berberine or berberine salt in preparation of medicines for preventing and / or treating phenylketonuria. Specifically, the enterococcus can obviously metabolize phenylalanine in an in-vitro culture medium system; the enterococcus belongs to the phylum of Thyrium, Bacillus, Lactobacillus and Enterococcus family. Meanwhile, the combination of the enterococcus and the berberine can significantly treat the phenylketonuria, and the plasma phenylalanine of a suckling mouse with the phenylketonuria can be reduced by 34.2% after 4 weeks of treatment. Therefore, the combination of the enterococcus and the berberine has an outstanding treatment effect in preventing and / or treating the phenylketonuria.

Description

Technical field [0001] The present invention relates to the field of medicine technology, and more particularly to a composition of enteric colony and berberine or a salt thereof in the preparation of prevention and / or treatment of benzprunzone iride drugs. Background technique [0002] Phenylketone urine (PKU) is a common amino acid metabolic disease, mainly due to the defective defects of the body, phenylalanine metabolic pathways, can not transform the formation of tyrosine, so benzene Avolura and phenylcyclic acid have a lot of accumulation in the body. Phenylketone urine is mainly symptoms in children 3-6 months, and symptoms are aggravated at one year of age. The clinical main characteristics are low-profile intellectual levels, poor mental state, eczema / skin scratches, and electrode abnormalities. If early diagnosis and early intervention treatment can be obtained, the above clinical manifestations do not occur, and the intellectual level of children is normal, and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/744A61P3/00A61K31/4375
CPCA61K31/4375A61K35/744A61P3/00A61K2300/00
Inventor 王琰蒋建东彭冉马殊荣潘利斌丛林
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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