A kind of degradable occluder coating and preparation method thereof

An occluder and coating technology, applied in coatings, devices for coating liquid on the surface, surgery, etc., to achieve the effects of preventing platelet adhesion and activation, promoting cell adhesion, and promoting endothelialization

Active Publication Date: 2022-05-27
SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is: how to improve the firmness of the surface coating of the degradable occluder, improve the anticoagulant performance of the occluder, and how to accelerate the endothelialization of the occluder

Method used

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  • A kind of degradable occluder coating and preparation method thereof
  • A kind of degradable occluder coating and preparation method thereof
  • A kind of degradable occluder coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A preparation method of a degradable occluder coating, comprising the following steps:

[0037] Step 1): Methacrylamidation treatment on the surface of the occluder skeleton

[0038] The occluder skeleton woven with polydioxanone wire was placed in a solution of 1,6-hexanediamine in isopropanol (0.08 g / mL), heated at 50 degrees Celsius for 10 minutes, and then sonicated with deionized water. cleaning. The aminated skeleton was then immersed in a freshly prepared 0.5wt% methacrylic anhydride aqueous solution, the pH was adjusted to 8.0 with sodium hydroxide solution, and after 3 hours of reaction at room temperature, ultrasonic cleaning was performed with deionized water, followed by ultrasonic cleaning with ethanol. .

[0039] The purpose of this step is to covalently introduce a double bond group on the surface of the plugger, so as to facilitate the subsequent free radical polymerization reaction, so that the modified substance is covalently introduced to the surfac...

Embodiment 2

[0044] A preparation method of a degradable occluder coating, comprising the following steps:

[0045] Step 1): Methacrylamidation treatment on the surface of the occluder skeleton

[0046] The occluder skeleton woven with polydioxanone wire was placed in a solution of 1,6-hexanediamine in isopropanol (0.08 g / mL), heated at 50 degrees Celsius for 10 minutes, and then sonicated with deionized water. cleaning. The aminated skeleton was then immersed in a freshly prepared 0.5wt% methacrylic anhydride aqueous solution, the pH was adjusted to 8.0 with sodium hydroxide solution, and after 3 hours of reaction at room temperature, ultrasonic cleaning was performed with deionized water, followed by ultrasonic cleaning with ethanol. .

[0047] The purpose of this step is to covalently introduce a double bond group on the surface of the plugger, so as to facilitate the subsequent free radical polymerization reaction, so that the modified substance is covalently introduced to the surfac...

Embodiment 3

[0052] A preparation method of a degradable occluder coating, comprising the following steps:

[0053] Step 1): Methacrylamidation treatment on the surface of the occluder skeleton

[0054]The occluder skeleton woven with polydioxanone wire was placed in a solution of 1,6-hexanediamine in isopropanol (0.08 g / mL), heated at 50 degrees Celsius for 10 minutes, and then sonicated with deionized water. cleaning. The aminated skeleton was then immersed in a freshly prepared 0.5wt% methacrylic anhydride aqueous solution, the pH was adjusted to 8.0 with sodium hydroxide solution, and after 3 hours of reaction at room temperature, ultrasonic cleaning was performed with deionized water, followed by ultrasonic cleaning with ethanol. .

[0055] The purpose of this step is to covalently introduce a double bond group on the surface of the plugger, so as to facilitate the subsequent free radical polymerization reaction, so that the modified substance is covalently introduced to the surface...

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Abstract

The invention discloses a degradable occluder coating and a preparation method thereof. The preparation method is as follows: first, soak the occluder in a solution of a compound containing at least two amino groups, take it out for cleaning, soak the occluder in an aqueous solution of methacrylic anhydride, take it out, and clean it with deionized water and ethanol; then Dip or spray gelatin methacrylamide solution and initiator solution on the surface of the occluder, or soak the occluder in a mixed solution of zwitterionic monomer, acrylic monomer and initiator, and trigger under heating or light conditions Polymerization, washing with deionized water after polymerization. In the present invention, gelatin is first fixed on the surface of the occluder. Gelatin is one of the components of the extracellular matrix, which contains a large number of cell adhesion sites, which can promote cell adhesion, and then covalently modify the zwitterionic polymer on the surface of the gelatin, which can prevent Non-specific adsorption of plasma proteins, thereby preventing platelet adhesion and activation, ultimately achieving both endothelialization and anticoagulation.

Description

technical field [0001] The invention relates to a degradable occluder coating and a preparation method thereof, belonging to the technical field of surgical instruments. Background technique [0002] The existing degradable occluder has the following defects: [0003] 1. Most of the existing biocompatible coatings are combined in a non-covalent form and are easy to fall off. [0004] 2. After the degradable occluder is implanted in the heart, because the occluder is in direct contact with the blood, it is easy to form a thrombus on the surface of the occluder, and the thrombus will fall off and cause stroke. Therefore, the existing occluder needs to improve the anticoagulant performance. [0005] 3. The biodegradable occluder will gradually degrade after being implanted into the human body and lose its mechanical properties, thus there is a risk of falling off. Therefore, the occluder needs to achieve endothelialization as soon as possible after implantation in the human b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/06A61L31/14A61L31/16B05D7/24B05D3/10
CPCA61L31/10A61L31/06A61L31/148A61L31/16B05D7/24B05D3/10A61L2420/02A61L2300/42A61L2300/606A61L2300/604A61L2300/252A61L2420/06A61L2300/41C08L89/00C08L33/26C08L67/04
Inventor 王云兵郭高阳杨立陈娟许贤春胡金鹏
Owner SICHUAN UNIV
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