Electrochemical synthesis method of 2-aryl-1, 2-diacetophenone

Abstract

The invention discloses an electrochemical synthesis method of 2-aryl-1, 2-diacetophenone, and the method comprises the following steps: by taking triaryl ethylene as a raw material, LiClO4 as an electrolyte and CH3CN as a solvent, carrying out constant-voltage reaction in an oxygen atmosphere at normal temperature through an electrode, after the reaction is finished, reducing pressure to remove the solvent, and carrying out column chromatography separation to obtain the product 2-aryl-1, 2-diacetophenone, namely the 2-aryl-1, 2-diacetophenone. The 2-aryl-1, 2-diacetophenone is prepared by adopting an electrochemical synthesis method, the reaction condition is mild, the reaction is room temperature, the reaction pressure is nearly normal pressure, the post-treatment is simple, the raw materials are cheap and easy to obtain, the production cost is low, the reaction steps are few, and only one-step reaction is adopted. The reaction is green and environment-friendly, current and oxygen participate in oxidation in the reaction process, and transition metal and a strong oxidant do not need to be used.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and relates to the synthesis of aryl ketones, in particular to an electrochemical synthesis method of 2-aryl-1,2-benzophenone. Background technique [0002] Aryl ketones are an important class of organic compounds, which widely exist in a variety of physiologically active natural products, and can be used to synthesize a variety of final products such as pharmaceutical compounds through the reaction of carbonyl groups, so they are widely used in medicine, Food, materials and other fields are playing an increasingly important role. It is precisely because of such a wide range of uses and chemical properties of aryl ketones that people have conducted a lot of research on their synthesis methods and achieved many results. [0003] Although various methods for synthesizing aryl ketones are disclosed in the prior art, these methods all belong to traditional chemical synthesis methods, which...

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Problems solved by technology

[0003] Although multiple methods for synthesizing aryl ketones have been disclosed in the prior art, these methods all belong to traditional chemical synthesis methods, which inevitably have large pollution and consumption Can you wait for more questions:

[0004]1) Use a cleaning oxidizing agent such as TBHP (tert-butyl alcohol peroxide) or H2O2( hydrogen peroxide), however these methods often require complex ligands and highly loaded metal catalysts;

[0005]2) The chemical oxidant used will require higher cost and produce a lot of solid waste;

[0006] Therefore, the existing synthetic methods still cannot meet the large-scale and simple requirements for the synthetic methods of aryl congeners

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