A kind of preparation method of thermosensitive hydrogel and thermosensitive hydrogel

A temperature-sensitive hydrogel and temperature-sensitive technology, applied in the field of biomedical materials, can solve problems such as single function and lack of promoting effect on wound repair, and achieve the effect of promoting accelerated healing, promoting wound repair, and removing active oxygen to promote wound repair

Active Publication Date: 2022-12-02
SHENZHEN INST OF ADVANCED TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, it is necessary to provide a temperature-sensitive hydrogel with both ROS scavenging and wound repair promotion functions in view of the technical defects in the prior art that the removal of ROS from chronic wounds is limited to the scavenging ability of active oxygen, the function is single, and the promotion of wound repair is lacking. Preparation

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  • A kind of preparation method of thermosensitive hydrogel and thermosensitive hydrogel
  • A kind of preparation method of thermosensitive hydrogel and thermosensitive hydrogel
  • A kind of preparation method of thermosensitive hydrogel and thermosensitive hydrogel

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preparation example Construction

[0038] see figure 1 , is a flow chart of the steps of the method 100 for preparing a thermosensitive hydrogel provided in an embodiment of the present application, including the following steps:

[0039] Step S110: preparing cerium-doped bioactive glass.

[0040] In some of these embodiments, the step of preparing cerium-doped bioactive glass specifically includes the following steps:

[0041] Step S111: adding ammonia water to the solvent to keep the solvent alkaline.

[0042] Specifically, the solvent is a mixed solution of absolute ethanol and water.

[0043] Further, a catalyst is added to the solvent, and the catalyst is cetyltrimethylammonium bromide.

[0044] Specifically, the added amount of the ammonia water is kept equal to the added amount of the silicon source.

[0045] It can be understood that the pH is adjusted by ammonia water to promote the hydrolysis of the silicon source, and the adjustable range is the volume ratio of ammonia water: tetraethyl orthosili...

Embodiment 1

[0065] 1. Preparation of cerium-doped bioactive glass:

[0066] With the volume ratio of 20ml:40ml dehydrated alcohol / water mixed solution as solvent, add 0.12g cetyltrimethylammonium bromide, 0.75ml ammoniacal liquor, make described solvent keep alkaline, stir until completely dissolving; Then Add 0.75ml tetraethyl orthosilicate and 0.055ml triethyl phosphate dropwise, finally add 0.10g cerium nitrate hexahydrate, 0.12g calcium nitrate tetrahydrate, stir magnetically at 35°C for 3h, and a light brown precipitate (nano grade biological glass sol); collect the white precipitate, wash it alternately with absolute ethanol and deionized water for 3 times, and then vacuum-dry to obtain a white lump; finally, transfer the white precipitate to a crucible for high-temperature calcination (heating rate: 1°C / min, Maintenance temperature: 650° C., maintenance time: 3 h) After high temperature treatment, naturally cool to obtain a powdery white powder, which is nano-scale cerium-doped bio...

Embodiment 2

[0073] 1. Preparation of cerium-doped bioactive glass:

[0074] With the volume ratio of 20ml:40ml dehydrated alcohol / water mixed solution as solvent, add 0.12g cetyltrimethylammonium bromide, 0.75ml ammoniacal liquor, make described solvent keep alkaline, stir until completely dissolving; Then Add 0.75ml tetraethyl orthosilicate and 0.055ml triethyl phosphate dropwise, finally add 0.10g cerium nitrate hexahydrate, 0.12g calcium nitrate tetrahydrate, stir magnetically at 37°C for 3h, and a light brown precipitate (nano Grade biological glass sol); collect the white precipitate, alternately wash twice with absolute ethanol and deionized water, and then vacuum-dry to obtain a white lump; finally, transfer the white precipitate to a crucible for high-temperature calcination (heating rate: 0.5°C / min, Maintenance temperature: 700° C., maintenance time: 2.5 h) After high temperature treatment, naturally cool to obtain a powdery white powder, which is nano-scale cerium-doped bioactiv...

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Abstract

The application provides a method for preparing a temperature-sensitive hydrogel. The temperature-sensitive hydrogel is obtained by loading the cerium-doped bioactive glass with a temperature-sensitive polymer material as a carrier, and the above-mentioned temperature-sensitive hydrogel After the glue comes into contact with body fluids, it degrades and releases bioactive ions such as cerium ions and silicon, calcium, etc., while removing excess reactive oxygen species from the wound surface, it also promotes wound repair and is helpful for the treatment of chronic wounds such as diabetic ulcers. In addition, the present application also provides a temperature-sensitive hydrogel.

Description

technical field [0001] The present application relates to the technical field of biomedical materials, in particular to a method for preparing a temperature-sensitive hydrogel and the temperature-sensitive hydrogel. Background technique [0002] Hydrogel materials are very important biomaterials, usually used as hemostatic materials and drug release carriers. Hydrogel is usually a very hydrophilic three-dimensional network structure, which swells rapidly in water and can hold a large volume of water without dissolving in this swollen state. Cellulose is the most abundant biodegradable polymer material in nature, with wide existence, excellent performance, abundant existence and low price. Methyl cellulose (MC) is the methyl ether of cellulose with simple structure and excellent performance. At present, methyl cellulose has been widely used in pharmaceutical excipients, such as adhesives, thickeners, etc., and is very safe to the human body. After MC is dissolved in water,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/02A61L24/00A61L24/08A61L24/04A61K33/244A61K33/00A61K33/08A61K33/42A61K31/722A61K31/785A61K9/06A61K47/38A61K47/10A61K47/36A61P17/02A61P3/10A61P31/02B82Y5/00B82Y40/00C03C4/00C03B19/12
CPCA61L24/02A61L24/0031A61L24/0015A61L24/001A61L24/08A61L24/046A61K33/244A61K33/00A61K33/08A61K33/42A61K31/722A61K31/785A61K9/06A61K47/38A61K47/10A61K47/36A61P17/02A61P3/10A61P31/02B82Y5/00B82Y40/00C03C4/0007C03B19/12A61L2300/412A61L2300/404A61L2400/12C08L1/02C08L1/284C08L5/08C08L71/02C08L77/04A61K2300/00
Inventor 赵晓丽常浩边少荃
Owner SHENZHEN INST OF ADVANCED TECH
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