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A kind of Prussian blue/calcium peroxide nanocomposite material and its preparation method and application

A nanocomposite material, Prussian blue technology, applied in the field of Prussian blue/calcium peroxide nanomaterials and its preparation, can solve the problems of limited sensitivity, slow calcification, and limited tumor treatment research

Active Publication Date: 2022-06-24
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is currently limited research on tumor therapy through tumor mineralization, and the only few mineralization methods currently focused on the study of tumor calcification
Preliminary studies have shown that tumor calcification can effectively inhibit tumor growth and metastasis, but has limited sensitivity in promoting medical diagnostic imaging of tumors, mainly due to the relatively weak degree of tumor calcification compared with physiological bone and tooth calcification , and the rate of calcification is slower

Method used

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  • A kind of Prussian blue/calcium peroxide nanocomposite material and its preparation method and application
  • A kind of Prussian blue/calcium peroxide nanocomposite material and its preparation method and application
  • A kind of Prussian blue/calcium peroxide nanocomposite material and its preparation method and application

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Embodiment Construction

[0027] The following examples can better understand the present invention, but are not limited to the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified.

[0028](1) Preparation of hollow Prussian blue nanoparticles: using Prussian blue as the precursor, prepared by acid etching. The specific experimental steps are as follows: 3 [Fe(CN) 6 ] (400 mg) and PVP (9 g) were dissolved in 120 mL of 10 mM aqueous HCl, then the mixture was transferred to a Teflon beaker and heated to 80°C in a water bath. After aging for 24 hours, Prussian blue nanoparticles were collected by centrifugation at 10,000 rpm and washed three times with deionized water. After vacuum drying, the Prussian blue nanoparticles were autoclaved in an acidic atmosphere. like figure 1 As shown in a, the Prussian blue obtained by transmission electron microscopy is a solid cubic nanoparticle. 60 mg of prepared solid Prussian blue and 300 mg of...

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Abstract

The invention discloses a Prussian blue / calcium peroxide nanocomposite material and its preparation method and application; the Prussian blue / calcium peroxide nanocomposite material prepared by the invention can mediate the iron mineralization of tumor cells; specifically, it can be used Through oral administration, intravenous administration, intratumoral interventional administration, lymph node interventional administration, etc., it mediates the iron mineralization of tumor cells and inhibits the growth and spread of tumor cells. Furthermore, the iron mineralization of tumor cells can also enhance the sensitivity of tumor tissue in ultrasound, CT and magnetic resonance medical imaging, and improve the accuracy of tumor diagnosis. The invention can realize the iron mineralization of tumor cells through the nano-medicine that mediates iron mineralization, thereby constructing an integrated system of diagnosis and treatment of tumors.

Description

technical field [0001] The invention relates to the technical field of tumor diagnosis and treatment, in particular to a Prussian blue / calcium peroxide nanomaterial and a preparation method and application thereof. The Prussian blue / calcium peroxide nanometer can mediate tumor mineralization and has application prospects in the integration of tumor diagnosis and treatment . Background technique [0002] Biomineralization is characterized by the accumulation of inorganic ions on organic substrates to form hard tissue materials, and plays an important role in the formation of hard tissue in vivo, such as the formation of bones and teeth in the human body under physiological conditions. Recent clinical studies have found that a certain degree of tumor mineralization is often accompanied by tumor radiotherapy and chemotherapy. It has also been reported that tumor mineralization is a potential marker of good prognosis and is positively correlated with the effect of tumor therapy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/40A61K33/26A61K47/69A61P35/00A61P35/04C01B15/043C01C3/12B82Y5/00B82Y30/00B82Y40/00
CPCA61K33/26A61K33/40A61P35/00A61P35/04A61K47/6949C01C3/12C01B15/043B82Y5/00B82Y30/00B82Y40/00C01P2004/80C01P2004/04A61K2300/00
Inventor 王本张凯鑫
Owner ZHEJIANG UNIV
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