Method for large-scale synthesis of tetrodotoxin
A tetrodotoxin and compound technology, applied in the field of artificial synthesis of tetrodotoxin, can solve problems such as lack of credibility, lack of value for large-scale synthesis and preparation of tetrodotoxin, and inability to produce tetrodotoxin on a large scale
Pending Publication Date: 2022-01-21
SHANGHAI SHENGPING MEDICAL EQUIP CO LTD +1
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AI-Extracted Technical Summary
Problems solved by technology
The invention provides a biological and chemical combined method for synthesis of tetrodotoxin, which specifically comprises the following steps: by taking benzyl acetate which is cheap and easy to obtain as a raw material, carrying out biological fermentation to obtain an optically pure intermediate ((5S, 6R)-5, 6-dihydroxycyclohexa-1, 3-dienyl) meta-acetate (formula I), performing a series of chemical conversions on the intermediate, and obtaining tetrodotoxin with the purity of more than 95% without purification of the final product. The method has the potential of large-scale production, and is an excellent substitute for the existing method for extracting from globefish.
Organic chemistryBulk chemical production
Chemical conversionBiotechnology +5
- Experimental program(7)
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