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Application of sodium carboxymethyl cellulose in improvement of amoxicillin colistin sulfate injection

A technology of sodium carboxymethyl cellulose and amoxicillin sulfuric acid, which can be applied to non-active ingredients in medical preparations, antibacterial drugs, liquid delivery, etc., can solve problems such as unfavorable drug filling, reducing foam volume, and abundant foam. , to achieve the effect of shortening grinding time, improving selectivity and increasing bioavailability

Pending Publication Date: 2022-02-01
河南中盛生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention solves the problem that the particle size reduction of amoxicillin sulfate colistin injection brings abundant foam, is unfavorable for drug filling, and affects the filling capacity, and proposes to add carboxyl Sodium methylcellulose to shorten the grinding time to achieve the desired particle size of the drug, thereby reducing the amount of foam

Method used

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  • Application of sodium carboxymethyl cellulose in improvement of amoxicillin colistin sulfate injection
  • Application of sodium carboxymethyl cellulose in improvement of amoxicillin colistin sulfate injection
  • Application of sodium carboxymethyl cellulose in improvement of amoxicillin colistin sulfate injection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Prescription

[0028] Raw materials: amoxicillin 12%, colistin sulfate 1%;

[0029] Excipients: aluminum stearate 0.5% (suspension agent 1), Span-80 0.5% (wetting agent), vitamin E 0.5% (antioxidant), carboxymethylcellulose sodium 0.2% (suspension agent 2 ), the balance is white oil (dispersion medium).

[0030] 2. Preparation process:

[0031] (1) Dissolving or dispersing the suspending agent 1 and the antioxidant in the prescribed amount in an appropriate amount of dispersing medium to prepare (1) liquid;

[0032] (2) Disperse the prescribed amount of wetting agent in an appropriate amount of dispersion medium, and then add amoxicillin and colistin sulfate to prepare (2) liquid;

[0033] (3) Pour an appropriate amount of dispersion medium into the colloid mill, and then slowly add the above liquid (1).

[0034] (4) Add suspending agent 2 sodium carboxymethyl cellulose, add liquid (2) while stirring, and start grinding after adding the drug.

[0035] (5) After ...

Embodiment 2

[0036] The impact of embodiment 2 carboxymethylcellulose sodium on the grinding time of amoxicillin colistin sulfate injection

[0037] Sodium carboxymethylcellulose group:

[0038] The preparation was prepared according to the prescription and configuration process of Example 1, wherein the grinding time was 20 minutes, 40 minutes, 50 minutes and 60 minutes respectively.

[0039] Control group without sodium carboxymethylcellulose:

[0040] Prescription: raw materials: amoxicillin 12%, colistin sulfate 1%;

[0041] Excipients: 0.5% aluminum stearate (suspending agent 1), 0.5% Span-80 (wetting agent), 0.5% vitamin E (antioxidant), and white oil (dispersing medium) as the balance. Configuration process except not adding suspending agent 2 carboxymethyl cellulose sodium in step (4), other are all identical with carboxymethyl cellulose sodium group.

[0042] The influence of table 1 sodium carboxymethyl cellulose on preparation milling time and particle size

[0043]

[00...

Embodiment 3

[0045] Embodiment 3 grinding effect comparison

[0046] Carry out steps (1) to (4) according to the configuration process of the sodium carboxymethylcellulose group and the control group, the grinding time is 40 minutes, and stand for 10 minutes after grinding.

[0047] The foam situation after placement of sodium carboxymethyl cellulose group and control group is as follows: figure 1 and figure 2 shown. The results showed that the foam in the preparation of the control group was abundant, and a large amount of foam was all arranged on the container wall and the surface of the preparation; while the sodium carboxymethyl cellulose group had no foam.

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Abstract

The invention relates to the technical field of preparations, in particular to application of sodium carboxymethyl cellulose in improvement of amoxicillin colistin sulfate injection. According to the invention, sodium carboxymethyl cellulose is added into the prescription of an amoxicillin colistin sulfate injection, so that the grinding time can be shortened to reach the required drug particle size, that is, the particle size of the drug liquid of the amoxicillin colistin sulfate injection can reach the target requirement in a relatively short time, the sedimentation rate of amoxicillin and colistin sulfate in a dispersion medium is reduced, and the dispersibility of amoxicillin and colistin sulfate in a dispersion medium is improved; and sodium carboxymethyl cellulose enables the raw material grinding time to be shortened when the amoxicillin colistin sulfate injection is prepared, and the situation that the filling volume is affected due to the fact that liquid medicine foam is generated in production due to temperature rise is avoided.

Description

technical field [0001] The invention relates to the technical field of preparations, in particular to the application of sodium carboxymethylcellulose in improving amoxicillin colistin sulfate injection. Background technique [0002] Amoxicillin in amoxicillin sulfate colistin suspension is a semi-synthetic broad-spectrum penicillin drug. Colistin sulfate is a polypeptide antibiotic widely used to treat infections caused by Gram-negative bacteria such as Escherichia coli, Salmonella, and Pseudomonas aeruginosa. The combination of amoxicillin and colistin sulfate has a synergistic antibacterial effect on Pasteurella, Escherichia coli, etc. It is mainly used clinically to treat infections caused by Gram-negative bacteria and Gram-positive bacteria in cattle, calves and pigs. Respiratory, gastrointestinal, genitourinary tract infections, skin and soft tissue infections, and secondary infections caused by bacteria. [0003] Suspension refers to a heterogeneous liquid preparati...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/43A61K47/22A61K47/38A61P31/04
CPCA61K9/10A61K31/43A61K47/38A61K47/22A61P31/04Y02A50/30
Inventor 李国辉姬星宇刘传辉焦金英刘胜海关欣李自波
Owner 河南中盛生物工程有限公司
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