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Preparation method and application of modified rhizoma smilacis glabrae sustained-release material

A slow-release material, the technology of tuckahoe, is applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc. Increase the frequency and speed of exercise, the effect of excellent sustained release performance

Pending Publication Date: 2022-02-08
HUAZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is almost no literature report about developing Smilax smilax as a sustained-release material as a drug sustained-release carrier. Although Smilax smilax has certain sustained-release properties, its sustained-release effect is not very satisfactory. In view of this, it is necessary to Develop a modified Smilax cocos slow-release material to solve the above problems

Method used

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  • Preparation method and application of modified rhizoma smilacis glabrae sustained-release material
  • Preparation method and application of modified rhizoma smilacis glabrae sustained-release material
  • Preparation method and application of modified rhizoma smilacis glabrae sustained-release material

Examples

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Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of modified soil tuckahoe slow-release material, comprising the steps of:

[0031] S1, pretreatment of raw materials: wash the rhizome of Smilax smilax, after drying, pulverizing, sieving, extruding and puffing, add it to the ethanol aqueous solution for soaking to obtain the pretreatment liquid; the aperture of the sieving screen is The size is 170 mesh; the extrusion temperature is 50° C., and the standing time is 60 min; the mass concentration of ethanol in the ethanol aqueous solution is 50%, and the addition amount of the ethanol aqueous solution is 25% of the mass of Smilax smilax. times, the soaking time is 30h;

[0032] S2. Ultrasonic enzymolysis modification: add cellulase and amylase to the pretreatment solution obtained in step S1, the final concentration of the cellulase and amylase is 15U / ml, and then place it in an ultrasonic breaker at a constant temperature After enzymatic hydrolysis, filter and recover under reduced pressure to obt...

Embodiment 2

[0035] A preparation method of modified soil tuckahoe slow-release material, comprising the steps of:

[0036] S1, pretreatment of raw materials: wash the rhizome of Smilax smilax, after drying, pulverizing, sieving, extruding and puffing, add it to the ethanol aqueous solution for soaking to obtain the pretreatment liquid; the aperture of the sieving screen is The size is 185 mesh; the extrusion temperature is 55° C., and the standing time is 55 min; the mass concentration of ethanol in the ethanol aqueous solution is 40%, and the addition amount of the ethanol aqueous solution is 20% of the mass of Smilax smilax. times, the soaking time is 25h;

[0037]S2. Ultrasonic enzymolysis modification: add hemicellulase, amylase and protease to the pretreatment solution obtained in step S1, the final concentration of the hemicellulase, amylase and protease is 12U / ml, and then put After constant temperature enzymolysis in an ultrasonic breaker, filter and recover under reduced pressur...

Embodiment 3

[0040] A preparation method of modified soil tuckahoe slow-release material, comprising the steps of:

[0041] S1, pretreatment of raw materials: wash the rhizome of Smilax smilax, after drying, pulverizing, sieving, extruding and puffing, add it to the ethanol aqueous solution for soaking to obtain the pretreatment liquid; the aperture of the sieving screen is The size is 200 mesh; the extrusion temperature is 60° C., and the standing time is 50 min; the mass concentration of ethanol in the ethanol aqueous solution is 30%, and the addition amount of the ethanol aqueous solution is 15% of the mass of Smilax smilax. times, the soaking time is 16h;

[0042] S2. Ultrasonic enzymolysis modification: add cellulase and phytase to the pretreatment solution obtained in step S1, the final concentration of the plant compound hydrolase is 10U / ml, and then place it in an ultrasonic breaker for constant temperature enzyme After decomposing, filter and recover under reduced pressure to obt...

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Abstract

The invention discloses a preparation method of a modified rhizoma smilacis glabrae sustained-release material. The preparation method comprises the following steps: S1, pretreatment of raw materials; S2, ultrasonic enzymolysis modification; S3, chemical grafting modification. An ultrasonic enzymolysis modification process is adopted; after the plant composite hydrolase is added, the plant cell walls of the rhizoma smilacis glabrae can be quickly hydrolyzed to obtain modified small molecular substances; in addition, on one hand, the system is heated by ultrasonic waves, so that the enzyme activity is maximized; meanwhile, sound waves can increase the motion frequency and speed of substance molecules and increase the penetrating power of a solvent; resin, polysaccharide and starch substances in the rhizoma smilacis glabrae are further modified and degraded; finally, a chemical grafting modification process is adopted, where polylactic acid is a macromolecular compound rich in hydroxyl groups, can react with carboxyl groups in the modified resin, polysaccharide and starch substances and serves as a side chain group to be added to main chains of the modified resin, polysaccharide and starch substances, and thus, the sustained-release material with more excellent performance is formed.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical preparations, and in particular relates to a preparation method and application of a modified soil tuckahoe slow-release material. Background technique [0002] Microencapsulation technology is a technology that uses natural or synthetic polymer film-forming materials to coat uniformly dispersed solid particles, liquids or gases to form tiny solid particles, in which the substance wrapped inside the microcapsule is called the core material. (or capsule core), and the coating film on the outside of the microcapsule is called wall material (or capsule wall, shell). A good wall material can make the core material have better bioavailability, prolong the half-life of the core material and delay its release, improve the efficacy of the core core material, and protect the core material from external environmental factors. Generally speaking, the greater the molecular weight of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/46A61K9/00A61K47/59A61K9/22A61K31/196A61K45/06
CPCA61K47/46A61K9/0002A61K47/59A61K9/2068A61K31/196A61K45/06
Inventor 魏宁王定军
Owner HUAZHONG PHARMA