Preparation method of polydiacetylene vesicle with excellent performance

A technology of polydiacetylene and diacetylene, which is applied in the field of preparation of polydiacetylene vesicles, can solve problems such as poor mechanical properties, uneven dispersion, agglomeration and precipitation, etc. Uniform distribution and obvious effect of hollow structure

Active Publication Date: 2022-03-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, polydiacetylene vesicles prepared by existing methods still have defects such as different sizes, irregular shapes, and uneven dispersion.
Polydiacetylene vesicles with these defects have problems such as agglomeration and precipitation, poor stability, poor mechanical properties, difficult surface modification, and low mechanochromic sensitivity, which greatly limit the development and application of polydiacetylene vesicles. application

Method used

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  • Preparation method of polydiacetylene vesicle with excellent performance
  • Preparation method of polydiacetylene vesicle with excellent performance
  • Preparation method of polydiacetylene vesicle with excellent performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: a kind of preparation method of polydiacetylene vesicle with excellent performance, it comprises the following steps:

[0052] S1. Dissolution: Dissolve the 10,12-pentacosadiynoic acid monomer in ethanol, the molar concentration of the monomer is 0.5mM, the dissolution time is 5min, and microfilter with PVDF containing 0.45μm after dissolution Filter through the filter head of the membrane to obtain the filtrate;

[0053] S2. Film formation: Pour the filtrate from step S1 into a spherical bottle, and form a monomer molecular film by rotary evaporation. The rotational speed of the rotary evaporator is 30r / min, the pressure is -0.065Mpa, and the temperature of the water bath is 68°C ;

[0054] S3. Add up water: slowly and uniformly add up water at 60°C to the formed monomer molecular film;

[0055] S4. Dispersion: Ultrasonic dispersion is used to disperse the monomer molecular film after adding up water to obtain an emulsion; the temperature of the ultraso...

Embodiment 2

[0058] Embodiment 2: a kind of preparation method of polydiacetylene vesicle with excellent performance, it comprises the following steps:

[0059] S1. Dissolution: Dissolve 10,12-trisosadiynoic acid monomer in ethanol, the molar concentration of the monomer is 2mM, the dissolution time is 5min, after dissolution, use a PVDF microfiltration membrane containing 0.45μm Filter through the filter head to obtain the filtrate;

[0060] S2. Film formation: Pour the filtrate from step S1 into a spherical bottle, and form a monomer molecular film by rotary evaporation. The rotational speed of the rotary evaporator is 40r / min, the pressure is -0.07Mpa, and the temperature of the water bath is 60°C. ;

[0061] S3. Add up water: slowly and uniformly add up water at 45°C to the formed monomer molecular film;

[0062] S4. Dispersion: Use ultrasonic dispersion to disperse the monomer molecular film after adding up water to obtain an emulsion; the temperature of the ultrasonic dispersion is...

Embodiment 3

[0065] Embodiment 3: a kind of preparation method of polydiacetylene vesicle with excellent performance, it comprises the following steps:

[0066] S1. Dissolution: Dissolve 10,12-pentacosadiyn-1-ol monomer in ethanol, the molar concentration of the monomer is 1mM, and the dissolution time is 5min. After dissolution, use PVDF containing 0.45μm Filter through the filter head of the microfiltration membrane to obtain the filtrate;

[0067] S2. Film formation: Pour the filtrate from step S1 into a spherical bottle, and form a monomer molecular film by rotary evaporation. The rotational speed of the rotary evaporator is 35r / min, the pressure is -0.068Mpa, and the temperature of the water bath is 63°C. ;

[0068] S3. Add up water: slowly and uniformly add up water at 50°C to the formed monomer molecular film;

[0069] S4. Dispersion: Ultrasonic dispersion is used to disperse the monomer molecular film after adding up water to obtain an emulsion; the temperature of the ultrasonic ...

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Abstract

The invention discloses a preparation method of a polydiacetylene vesicle with excellent performance, and solves the problems of poor stability, difficulty in surface modification, low mechanochromic sensitivity, poorer repeatability and the like of the polydiacetylene vesicle prepared by the existing method due to the defects of non-uniform particle size distribution, irregular shape, rough surface and the like. The polydiacetylene vesicles prepared by adopting the preparation method of the polydiacetylene vesicles with excellent performance, provided by the invention, are regular in shape, obvious in hollow structure, uniform in size distribution and good in mechanical property and discoloration property; in addition, the morphological structure and performance of the polydiacetylene vesicles are characterized by utilizing various characterization methods, the defect that the polydiacetylene vesicles are used in the aspects of structural performance control such as immunolabeling, immunohistochemistry and diagnostic reagents by utilizing the mechanochromism characteristics at present is overcome, and a new thought is provided for preparation of the polydiacetylene family vesicles.

Description

technical field [0001] The invention belongs to the technical field of small molecule self-assembly, and in particular relates to a method for preparing polydiacetylene vesicles with excellent performance. Background technique [0002] Biosensor is an emerging sensing technology. Because of its high sensitivity, good specificity and rapid detection, it has excellent application prospects in the field of biological detection. Polydiacetylene vesicles occupy an important position in the field of biosensors due to their special optical properties. The diacetylene family can spontaneously form vesicles in aqueous solution. After proper surface modification of polydiacetylene vesicles to prepare sensors, when specific sensitive substances are bound to the surface of the vesicles, it will occur in the visible wavelength range Blue to red color transition. Through the change of vesicle color, the sensor can be used to sense various external stimuli such as environmental temperat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/32A61K31/20
CPCA61K9/1273A61K47/32A61K31/20
Inventor 蒋波尹越王宁馨罗振宇郭纪彤刘彬朱凌璇
Owner SICHUAN UNIV
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