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Facial antibacterial care solution containing recombinant human lysozyme

A technology of human lysozyme and care solution, which is applied in the direction of skin care preparations, medical preparations containing active ingredients, enzymes, etc., can solve problems such as ineffectiveness, and achieve the effect of improving acne and strong antibacterial effect

Pending Publication Date: 2022-03-11
义乌市欧雅化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, lysozyme can only act on the cell wall of the target microorganism, but not on other substances

Method used

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  • Facial antibacterial care solution containing recombinant human lysozyme
  • Facial antibacterial care solution containing recombinant human lysozyme
  • Facial antibacterial care solution containing recombinant human lysozyme

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the preparation of recombinant human lysozyme

[0030] According to the preferred codons of P. pastoris, the sequence of human lysozyme (NCBI accession number: NM_000239.2) was artificially synthesized without its own signal peptide, and the expression of human lysozyme with natural N-terminal human lysozyme guided by the α-factor signal peptide of Saccharomyces cerevisiae was constructed Gene recombinant pPIC9k-LYC6 secreted Pichia expression vector. The linearized recombinant plasmids were electrotransformed into GS115 respectively, and integrated into the yeast genome at a specific site, and through nutritional screening and multi-copy identification, a multi-copy insertion strain with a stably integrated expression vector was obtained. Through shaking flask culture and induced expression, the strains with high protein expression and activity were initially screened out, and then density fermentation was carried out in 50L and 500L fermenters for amplif...

Embodiment 2

[0032] A facial treatment lotion containing human lysozyme, comprising:

[0033] Recombinant human lysozyme, 10000 international units of lysozyme per ml; azelaic acid 2%; citric acid 5%; salicylic acid 0.5%; nicotinamide 0.5%; ethylhexylglycerin 0.5%; Lauramidopropyl betaine 1%, the rest is made by mixing purified water.

Embodiment 3

[0035] A facial treatment lotion containing human lysozyme, comprising:

[0036] Recombinant human lysozyme 20,000 lysozyme international units per ml; azelaic acid 4%; citric acid 5%; salicylic acid 1.5%; niacinamide 3%; ethylhexylglycerin 2%; Amidopropyl betaine 1%, the rest is made by mixing purified water.

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PUM

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Abstract

The invention relates to a facial antibacterial care solution containing human lysozyme, which is a skin sterilizing and cleaning product containing the human lysozyme and further containing other antibacterial components, and the human lysozyme can break cell walls of gram-positive bacteria, has a destructive effect on pathogenic bacteria, and can be used for sterilizing and cleaning the skin. The human lysozyme is combined with other antibacterial or auxiliary components of azelaic acid, salicylic acid, citric acid and nicotinamide in the formula, can effectively kill propionibacterium acnes, staphylococcus epidermidis and staphylococcus aureus and improve acnes and whelks, and is an excellent skin cleaning agent.

Description

technical field [0001] The invention relates to a face antibacterial care liquid, especially a face care liquid containing recombinant human lysozyme. Background technique [0002] Acne is also known as acne. Facial acne is pimples on the face. This is a common skin disease. It is generally more common in teenagers. Of course, facial acne has no age limit. [0003] There are many types of facial acne, mainly pleomorphic skin lesions such as facial acne, papules, pustules, and nodules. In severe cases, it may also suppurate. The occurrence of acne is mainly related to excessive sebum secretion, blockage of pilosebaceous gland ducts, and oil can not be discharged in time to block pores, which will cause a large number of anaerobic bacteria Propionibacterium acnes to proliferate and destroy epidermal cells, causing inflammation. Propionibacterium acnes, as an anaerobic bacterium, does not cause disease under aerobic conditions, but when the sebaceous duct orifice is blocked a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/66A61K8/67A61K8/368A61K8/365A61K8/362A61K38/47A61Q19/00A61Q17/00A61P17/10A61P17/04A61P17/00A61P37/08A61K31/194A61K31/455A61K31/60
CPCA61K8/66A61K38/47C12Y302/01017A61K31/60A61K31/194A61K31/455A61K8/362A61K8/368A61K8/365A61K8/675A61Q19/00A61Q17/005A61P17/10A61P17/04A61P17/00A61P37/08A61K2300/00
Inventor 喻恒锋喻致远曹立环潘军波
Owner 义乌市欧雅化妆品有限公司
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