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Composite nano-material for photodynamic and photo-thermal combined treatment as well as preparation method and application of composite nano-material

A technology of composite nanomaterials and combined therapy, applied in the direction of photodynamic therapy, nanotechnology for materials and surface science, chemical instruments and methods, etc.

Pending Publication Date: 2022-03-15
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] This application discloses a composite nanomaterial for photodynamic and photothermal combined therapy and its preparation method and application, so as to solve the shortcomings of existing photodynamic therapy in terms of cancer treatment efficiency, etc.

Method used

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  • Composite nano-material for photodynamic and photo-thermal combined treatment as well as preparation method and application of composite nano-material
  • Composite nano-material for photodynamic and photo-thermal combined treatment as well as preparation method and application of composite nano-material
  • Composite nano-material for photodynamic and photo-thermal combined treatment as well as preparation method and application of composite nano-material

Examples

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preparation example Construction

[0051] In the first aspect, the embodiment of the present application provides a method for preparing a composite nanomaterial for combined photodynamic and photothermal therapy, including the following steps:

[0052] Dispersing graphite phase carbon nitride in water, adding copper acetate and stirring, mixing and stirring the obtained solution with thiourea aqueous solution to obtain a suspension, performing a hydrothermal reaction on the suspension to obtain graphite phase carbon nitride loaded with copper sulfide ;

[0053] Disperse the graphite phase carbon nitride loaded with copper sulfide in water, add potassium permanganate aqueous solution, polyallylamine hydrochloride solution, mix and stir to obtain graphite phase nitrogen loaded with copper sulfide and manganese dioxide carbonization;

[0054] The graphite-phase carbon nitride loaded with copper sulfide and manganese dioxide was dispersed into the F127 aqueous solution, and stirred overnight to obtain the composi...

Embodiment 1

[0078] This embodiment provides a composite nanomaterial for combined photodynamic and photothermal therapy, the preparation method of which includes the following steps:

[0079] Preparation of graphitic carbon nitride: Put 5g of melamine into a crucible with a lid, place it in a muffle furnace, heat it up to 550°C at a rate of 2.5°C / min, heat it for 4 hours, cool it to room temperature, and collect the yellow powder and washed with deionized water and dried. Then put the prepared yellow powder into a planetary ball mill rotating at 500rpm and grind for 6h. After grinding, the product is collected by filtration, which is ultrafine graphitic carbon nitride, which is a sheet-like nanomaterial, referred to as CNs. Wherein the ultrafine graphitic carbon nitride refers to the graphitic carbon nitride whose particle size is less than or equal to 200nm.

[0080] Preparation of graphitic carbon nitride loaded with copper sulfide: Disperse 0.5 g of CNs in 60 mL of deionized water. A...

Embodiment 2

[0084] The difference between this example and Example 1 is that in the step of preparing graphite-phase carbon nitride loaded with copper sulfide, the mass percentage of copper sulfide in graphite-phase carbon nitride is 3%.

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Abstract

The invention relates to the technical field of medical materials, in particular to a composite nanomaterial for photodynamic and photo-thermal combined therapy and a preparation method and application thereof. The preparation method of the composite nanomaterial comprises the following steps: dispersing graphite phase carbon nitride in water, adding copper acetate, stirring, mixing the obtained solution with a thiourea aqueous solution, stirring to obtain a suspension, and carrying out a hydrothermal reaction on the suspension to obtain graphite phase carbon nitride loaded with copper sulfide; dispersing the graphite phase carbon nitride loaded with copper sulfide in water, adding a potassium permanganate aqueous solution and a polyallylamine hydrochloride solution, and mixing and stirring to obtain graphite phase carbon nitride loaded with copper sulfide and manganese dioxide; and dispersing the graphite-phase carbon nitride loaded with copper sulfide and manganese dioxide into an F127 aqueous solution, and stirring overnight to obtain the composite nano material. The composite nano material has good photothermal conversion capability, active oxygen generation capability, glutathione consumption capability and the like, and is suitable for photodynamic and photothermal combined therapy.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a composite nanomaterial used for photodynamic and photothermal combined therapy and its preparation method and application. Background technique [0002] Traditional cancer treatment methods mainly include surgical resection, chemotherapy and radiotherapy, etc., but these methods have the disadvantages of low curative effect and large side effects. Therefore, new cancer treatment methods that are more effective and less toxic to patients have become a research hotspot. [0003] Among these new cancer treatment methods, Photodynamic Therapy (PDT) has attracted attention because of its potential therapeutic effect and relatively mild harm to patients. However, when this technology is applied to tumor treatment, the treatment efficiency of photodynamic therapy will be limited due to the hypoxic tumor microenvironment of solid tumors, and even lead to tumor invasion and me...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K33/32A61K9/51A61K47/10A61P35/00B82Y5/00B82Y30/00B82Y40/00C01B21/082C01G3/12C01G45/02
CPCA61K41/0057A61K41/0052A61K33/32A61K9/5146A61K9/5192A61P35/00B82Y5/00B82Y30/00B82Y40/00C01B21/0605C01G3/12C01G45/02C01P2004/80A61K2300/00
Inventor 熊建文李淼淼
Owner SOUTH CHINA NORMAL UNIVERSITY
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