Ethanol-free composite microemulsion system antibacterial spray and preparation method thereof

A microemulsion and system technology, applied in botany equipment and methods, antibacterial drugs, antifungal agents, etc., can solve the problems of low bioavailability and poor stability, achieve enhanced antibacterial effect, low equipment requirements, and high preparation process simple effect

Pending Publication Date: 2022-03-22
SHANGHAI INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide an antibacterial spray of an ethanol-free composite microemulsion system and its preparation method to solve the problems of plant essential oils in the prior art such as water solubility, poor stability and low bioavailability

Method used

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  • Ethanol-free composite microemulsion system antibacterial spray and preparation method thereof
  • Ethanol-free composite microemulsion system antibacterial spray and preparation method thereof
  • Ethanol-free composite microemulsion system antibacterial spray and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0032] First mix lavender essential oil with carvacrol at a mass ratio of 10:1, and with citronellol at a mass ratio of 1:1, and then follow the mass ratios of lavender essential oil and cosurfactant dipropylene glycol at 1:0, 1:1, Add dipropylene glycol at 1:2 and 1:3, and finally according to the mass ratio of surfactant to (lavender essential oil / dipropylene glycol): 0:10, 1:9, 2:8, 3:7, 4:6, 5: 5, 6: 4, 7: 3, 8: 2, 9: 1 and 10: 0 to configure a mixed system, shake in a 150rpm water bath at 25°C until uniform, then add distilled water dropwise at intervals of 1 to 3 hours, shake, and the recording system changes from clear to cloudy , and calculate the proportion of each component in the system at the critical point, and draw a pseudo-ternary phase diagram with lavender essential oil / dipropylene glycol, surfactant and water as three vertices respectively. The grid area is the non-microemulsion phase area, the blank gray area is the microemulsion phase area, and the boundary...

Embodiment 2

[0035] In the pseudo-ternary phase diagram in which the mass ratio of lavender essential oil and dipropylene glycol is 1:3, choose the infinite dilution line with the smallest dilutable ratio, that is, a wireless dilution line with a relatively small surfactant content in the wireless dilutable line, which is figure 1Point LR3 in the single-phase region. The specific process is as follows: mix lavender essential oil and carvacrol at a mass ratio of 10:1, shake evenly, then add dipropylene glycol according to the mass ratio of lavender essential oil and co-surfactant dipropylene glycol 1:3, continue shaking evenly as the oil phase, Finally, configure the mixed system according to the mass ratio of the oil phase to Tween 80 of 5:5. After shaking in a 150rpm water bath at 25°C until uniform, slowly add distilled water dropwise until the concentration of lavender essential oil is 2%, and the concentration of carvacrol is 0.2%. Fill it into an atmospheric pressure spray bottle. Be...

Embodiment 3

[0037] In the pseudo-ternary phase diagram in which the mass ratio of lavender essential oil and dipropylene glycol is 1:3, choose the infinite dilution line with the smallest dilutable ratio, that is, a wireless dilution line with a relatively small surfactant content in the wireless dilutable line, which is figure 2 Point LT3 in the single-phase region. The specific process is as follows: mix lavender essential oil and citronellol in a mass ratio of 1:1, shake evenly, then add dipropylene glycol according to the mass ratio of lavender essential oil and co-surfactant dipropylene glycol 1:3, continue shaking evenly as the oil phase, Finally, configure the mixed system according to the mass ratio of the oil phase to Tween 80 as 4: 6. After shaking in a 150rpm water bath at 25°C until uniform, slowly add distilled water dropwise until the concentration of lavender essential oil is 2%, and the concentration of citronellol is 2%. Fill it into an atmospheric pressure spray bottle...

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Abstract

The invention discloses an ethanol-free composite microemulsion system antibacterial spray and a preparation method thereof. The antibacterial spray comprises the following raw materials: a natural active substance, a cosurfactant, a nonionic surfactant and distilled water. The preparation method comprises the following steps: adding a cosurfactant into a natural active substance, uniformly mixing, and then adding a nonionic surfactant to obtain a clear and transparent microemulsion system; and putting the microemulsion system into a shaking table, oscillating in a water bath until the microemulsion system is uniform, dropwise adding distilled water at intervals, continuously oscillating, and filling a normal-pressure spray bottle with the microemulsion system after the microemulsion system recovers a clear and transparent state. According to the invention, the lavender essential oil is taken as a main component and is compounded with the other two active components respectively, so that the purpose of synergistic interaction is achieved, and the antibacterial effect of the spray is greatly enhanced; meanwhile, the prepared composite micro-emulsion system antibacterial spray does not contain ethanol, is low in surfactant content, clear and transparent in appearance, small in particle size, good in stability and good in spreading and wettability, and the preparation method is simple and convenient.

Description

technical field [0001] The invention relates to an antibacterial spray of an ethanol-free composite microemulsion system and a preparation method thereof, belonging to the technical field of antibacterial daily necessities. Background technique [0002] Most of the antibacterial drugs commonly used in the past: highly toxic, threatening human health, and their frequent use has led to the increasing resistance of microorganisms to traditional chemicals and drugs. Essential oils, as a natural antimicrobial agent and an alternative to chemical fungicides, have attracted great attention in industries such as food, cosmetics, and pharmaceuticals. Therefore, in recent years, as consumers have become more aware of the use of natural ingredients, Essential oils are becoming more and more popular. [0003] Lavender is a plant of the genus Lavender of the Lamiaceae. Lavender essential oil is extracted from lavender. It can clear away heat and detoxify, clean the skin, control oil con...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/12A61K9/107A61K47/10A61K47/26A61P31/02A61P31/04A61P31/10A61P25/20A61L9/013A61L9/01A01N65/22A01N31/08A01N31/02A01N25/06A01P1/00A01P3/00A61K31/05A61K31/045A61L101/56A61L101/34
CPCA61K36/53A61K31/05A61K31/045A61K9/0078A61K9/12A61K9/1075A61K47/10A61K47/26A61P31/02A61P31/04A61P31/10A61P25/20A61L9/013A61L9/01A01N65/00A01N65/22A01N31/08A01N31/02A01N25/06A61L2209/21A61L2101/34A61K2300/00Y02A50/30
Inventor 王一非姜政兆宋晓秋叶琳杨晓波张健
Owner SHANGHAI INSTITUTE OF TECHNOLOGY
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