Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition capable of reducing hyperuricemia level in serum and application thereof

A composition and high uric acid technology, applied in the field of utilization of marine biological resources, to achieve the effects of inhibiting and adenosine deaminase activity, preventing and treating kidney tissue lesions, and reducing high uric acid levels

Pending Publication Date: 2022-04-05
YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although drug-based treatment of high uric acid levels is the mainstream approach, simple drug use will more or less cause side effects, and the current prior art lacks an edible functional food that can effectively reduce high levels of uric acid in serum

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition capable of reducing hyperuricemia level in serum and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Formulating the Composition

[0029] Put Antarctic krill oil, garlic oil and astaxanthin in a stainless steel tank with a mass ratio of 670:326:4, mix and stir evenly, and grind the mixed oil through a colloid mill for 2-3 times to obtain the composition.

Embodiment 2

[0031] The composition capable of reducing high uric acid levels in serum can be made into capsules and emulsions. The specific method is as follows,

[0032] Capsule: take the above preferred formula combination (Example 1) as the content; mix gelatin, water, glycerin, and sorbitol liquid, heat to 70-80°C, stir and melt, keep warm for 1-2 hours, filter and degas Finally, the glue is obtained; the contents and the glue are made into capsules by dripping or pressing.

[0033] Emulsion: Add the above-mentioned preferred formula combination (Example 1) into water containing emulsifier or stabilizer, vortex and mix well, perform ultrasonication, and then undergo high-speed homogenization treatment at 8000-10000r / min for 5-20 minutes to form a uniform Emulsified state, made into emulsion.

Embodiment 3

[0034] Example 3: Therapeutic experiment of the composition on hyperuricemia model mice

[0035] 3.1 Experimental instruments and reagents

[0036] Experimental gavage needle (Shanghai Boli Pigeon Industry and Trade Co., Ltd.), Neofuge 15R high-speed refrigerated centrifuge (Shanghai Lishen Scientific Instrument Co., Ltd.), CMax Plus microplate reader (Megu Molecular Instruments (Shanghai) Co., Ltd.), UV1102Ⅱ ultraviolet / visible spectrophotometer (Shanghai Tianmei Scientific Instrument Co., Ltd.), CX31RTSF optical microscope (Japan Olympus Company), BAS224S-CW electronic balance (Sartorius (Beijing) Scientific Instrument Co., Ltd.), HH-4 type Digital display constant temperature water bath (Changzhou Zhiborui Instrument Manufacturing Co., Ltd.), yeast extract, potassium oxonate, pig bile salt (Sinopharm Chemical Reagent Co., Ltd.), uric acid kit, urea nitrogen kit, creatinine kit, yellow Purine oxidase kit, adenosine deaminase kit (Nanjing Jiancheng Bioengineering Institute)....

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a composition capable of reducing hyperuricemia level in serum. The composition comprises marine grease rich in polyunsaturated fatty acid, garlic oil and astaxanthin. According to the composition prepared by compounding the euphausia superba oil, the garlic oil and the astaxanthin, provided by the invention, specific experiments prove that the composition can be used for remarkably reducing the hyperuricemia level in serum, and the positive effect of the composition on resisting hyperuricemia is verified on the animal level; through compounding of the three components in the composition, a good uric acid level reducing effect is achieved, specifically, the high uric acid level is reduced, and a certain relieving effect on hyperuricemia and gout is achieved. In addition, through practical verification, the composition provided by the invention can inhibit the activity of liver xanthine oxidase and adenosine deaminase, so that the generation of uric acid is reduced; in addition, the composition can also reduce the content of serum creatinine and urea nitrogen, prevent and treat kidney tissue lesions, and play a certain role in protecting the kidney.

Description

technical field [0001] The invention belongs to the technical field of utilization of marine biological resources, and in particular relates to a composition capable of reducing high uric acid levels in serum, and its application in products for preventing and / or treating hyperuricemia / gout. Background technique [0002] Hyperuricemia is a metabolic disease caused by excessive uric acid production or decreased uric acid excretion due to purine metabolism disorders, and its main feature is increased blood uric acid concentration. Hyperuricemia is not only the initial stage of gout, but also closely related to abnormal lipid metabolism, diabetes, coronary heart disease, hypertension, obesity, metabolic syndrome, and kidney damage. [0003] Uric acid-lowering drugs commonly used in clinical practice can be divided into two types: uric acid synthesis inhibitors and uricosuric agents, which reduce blood uric acid concentration from two aspects: inhibiting uric acid synthesis and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/115A23L33/12A23L33/10A23L33/105A23L17/00A61K36/8962A61P19/06A61K35/60A61K35/612A61K31/122
Inventor 刘小芳冷凯良苗钧魁于源刘建志唐一新宫玉雪
Owner YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com