Adsorption resin as well as preparation method and application thereof

A technology of adsorption resin and macroporous resin, applied in the field of adsorption resin and its preparation, can solve the problems of inability to significantly improve the 28-day survival rate of patients, inability to effectively treat sepsis, removal of endotoxin and pathogenic bacteria, and the like, Achieve the effect of improving blood compatibility, ensuring hydrophobicity and inhibiting bacterial infection

Pending Publication Date: 2022-04-08
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the practice at home and abroad has proved that the effective treatment of sepsis cannot be achieved simply by removing endotoxin or cytokine adsorbents.
At present, the independent endotoxin adsorption column (such as PMX polymyxin B adsorption column of Toray Japan) and the independent cytokine adsorption column (such as cytosorb adsorption column and CA cytokine adsorption column, etc.) on the market can only be unilaterally To clear or improve a certain index of patients with sepsis, the results of multiple randomized controlled clinical trials showed that polymyxin B adsorption column could not significantly improve the 28-day survival rate of patients with sepsis, the specific reasons It may be that the polymyxin B adsorption column cannot effectively remove endotoxin and pathogenic bacteria during the treatment process, and the polymyxin B adsorption column cannot adsorb bacteria and other pathogenic factors in the blood of sepsis patients. The treatment principle Single, and a single endotoxin adsorption treatment mode may seriously affect its therapeutic effect on sepsis, thus failing to achieve better therapeutic effect

Method used

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  • Adsorption resin as well as preparation method and application thereof
  • Adsorption resin as well as preparation method and application thereof
  • Adsorption resin as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0033] figure 1 It is a flow chart of the process for preparing the adsorption resin provided in the examples of the present application. to combine figure 1 As shown, the second aspect of the embodiment of the present application provides a method for preparing an adsorbent resin, comprising:

[0034] Step S1. Epoxidatively modifying the polystyrene-based macroporous resin to obtain a macroporous resin containing epoxy groups.

[0035] Specifically, polystyrene monomers and polyvinyl crosslinking agents are suspended and polymerized in a dispersion medium under the action of porogens and initiators to obtain polystyrene-based macroporous resins; A compound containing epoxy groups is added to the vinyl macroporous resin for epoxy modification reaction to obtain a macroporous resin containing epoxy groups.

[0036] In order to ensure that there are enough double bonds to participate in the epoxy modification reaction of compounds containing epoxy groups, ensure that the oute...

Embodiment 1

[0070] The present embodiment provides a kind of preparation method of adsorption resin, comprises the following steps:

[0071] (1) Epoxidation modification of polystyrene-based macroporous resin:

[0072] Add 600mL of aqueous solution containing 1.5wt% gelatin to a 1000mL three-necked flask, add 40g of divinylbenzene, 10g of ethylstyrene, 25g of porogen toluene, 10g of n-heptane, 25g of n-octanol, and diisobutyl ketone 20g, initiator 0.5g mixed organic phase composed of peroxy-2-hexylhexanoic acid tert-butyl ester, under mechanical stirring, control the size of oil droplet, raise the temperature to 70°C and react for 2h, take a sample to observe the oil droplet after setting , add 10g of allyl glycidyl ether dropwise to the three-necked flask, and keep it at 70°C to continue the reaction for 5 hours, then raise the reaction temperature to 80°C, and continue the reaction for 4 hours to fully cross-link and solidify. After the reaction, Cool, filter out the mother liquor, ext...

Embodiment 2

[0078] The present embodiment provides a kind of preparation method of adsorption resin, comprises the following steps:

[0079] (1) Epoxidation modification of polystyrene-based macroporous resin:

[0080] Add 600mL of aqueous solution containing 1.5wt% gelatin to a 1000mL three-necked flask, add 31.5g of divinylbenzene, 18.5g of ethylstyrene, 35g of porogen toluene, 15g of n-heptane, and 15g of methyl isobutyl carbinol , Methyl isobutyl ketone 15g, initiator 0.5g mixed organic phase of peroxy-2-hexylhexanoic acid tert-butyl ester, under mechanical stirring, control the size of the oil droplet, heat up to 70 ° C after 2 hours of reaction, After taking a sample to observe the shape of the oil droplets, add 15g of allyl glycidyl ether dropwise to the three-necked flask, and keep it at 70°C for 5 hours, then raise the reaction temperature to 80°C, and continue the reaction for 4 hours to fully crosslink After solidification, after the reaction, cool down, filter out the mother ...

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Abstract

The invention provides an adsorption resin and a preparation method and application thereof, the adsorption resin takes macroporous resin containing an epoxy group as a carrier, adsorption ligands are immobilized, heparin is immobilized on the adsorption ligands, the adsorption ligands are polylysine and polyethyleneimine, and the heparin is an epoxy group. Both the polylysine and the polyethyleneimine react with an epoxy group to be immobilized on the carrier, and the epoxy group is obtained by performing epoxy modification on polystyrene-based macroporous resin. The adsorption resin provided by the invention can be used for whole blood perfusion of a sepsis patient, has treatment and regulation effects on bacterial infection, endotoxin, cytokine storm, blood coagulation function and the like in the body of the sepsis patient, and provides a more comprehensive and more effective treatment effect for the sepsis patient.

Description

technical field [0001] The invention relates to the technical field of blood purification, in particular to an adsorption resin and its preparation method and application. Background technique [0002] Sepsis is a series of clinical syndromes in which the body's immune system is dysregulated due to bacterial, viral or fungal infection, resulting in life-threatening organ dysfunction. Sepsis has a high incidence in critically ill patients and is the leading cause of death in critically ill patients. It is reported that there are more than 18 million cases of severe sepsis every year in the world, and about 1400 people die of sepsis and its complications every day worldwide. [0003] Sepsis can be caused by infection at any site, and its pathogenic microorganisms include bacteria, fungi, viruses, and parasites. Although the fundamental pathogenesis of sepsis is not yet clear, studies have shown that bacterial endotoxins can induce sepsis, and Infection factors in sepsis activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30C08J9/36C08L25/06A61M1/36
Inventor 董凡邵柯谢煜高博
Owner JAFRON BIOMEDICAL
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