Unlock instant, AI-driven research and patent intelligence for your innovation.

Active composition for mouthwash, mouthwash and preparation method of mouthwash

The technology of a composition and mouthwash, which is applied in the direction of drug combination, cosmetic preparations, oral care, etc., can solve the problems of waste of resources, environmental pollution, waste of navel orange peel, etc., and achieve the effect of good heat resistance and cold resistance stability

Pending Publication Date: 2022-04-12
GANNAN MEDICAL UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main consumption methods of navel oranges in my country are the sale of fresh fruit and the production of orange juice. According to the survey, a large amount of orange peels have not been developed and utilized during the processing and production of navel orange related products, but are directly discarded or dried and then incinerated. The waste is also a pollution to the environment
The research on the comprehensive utilization of navel orange peel is not enough, a large amount of discarded navel orange peel is wasted, and it also pollutes the environment, so the research on the reuse of orange peel is of great significance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Active composition for mouthwash, mouthwash and preparation method of mouthwash
  • Active composition for mouthwash, mouthwash and preparation method of mouthwash
  • Active composition for mouthwash, mouthwash and preparation method of mouthwash

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] According to the present invention, the present invention provides a kind of preparation method of mouthwash, wherein, this method comprises: Thymol, menthol are dissolved in wetting agent, drop into eucalyptol, methyl salicylate, orange Stir skin essential oil and sodium fluoride evenly, add pure water under stirring condition, add solubilizer after the solution becomes turbid until the solution becomes clear, then add preservatives, flavoring agents, and optional humectants, and add pure water to make up volume.

[0058] According to the present invention, preferably, contain by dosage:

[0059] Orange peel essential oil 0.1%-1% (v / v), methyl salicylate 0.1%-1% (v / v), eucalyptol 0.1%-1.5% (v / v), thymol 0.01% -0.05% (m / v), menthol 0.05%-0.5% (m / v), sodium fluoride 0.01%-0.08% (m / v), optionally humectants 0.1%-1% (m / v ), wetting agent 10%-50% (v / v), solubilizer 1%-10% (m / v), flavoring agent 0.05%-1% (m / v), preservative 0.01%-0.5% ( m / v), all the other are water; adopt...

Embodiment approach

[0067] According to a preferred embodiment of the present invention, it is illustrated that the preparation of mouthwash comprises the following steps:

[0068] First, measure 20 mL of propylene glycol (or ethanol: glycerin = 2: 1) in a 150 mL beaker with a graduated cylinder, then weigh 0.1 g of thymol and 0.2 g of menthol with an electronic analytical balance, dissolve them in propylene glycol, and then drop Add 10 drops of eucalyptol, 5 drops of methyl salicylate, and 5 drops of orange peel essential oil and stir evenly. Place the beaker on a magnetic stirrer to stir, slowly add 75mL of pure water, the solution gradually becomes cloudy, and then weigh the beaker. Add about 1.5g of Loxamer 407 slowly in batches until the solution becomes clear, then weigh 0.02g of sodium fluoride, 0.2g of sodium saccharin, and 0.1g of sodium benzoate into a beaker to dissolve in sequence, and add water to make up to 100mL.

[0069] The mouthwash of the present invention has orange fragrance,...

Embodiment

[0082] Extraction of volatile oil from navel orange peel

[0083] Take 500g of fresh navel orange peel, cut off the white sac of the inner cortex with a blade, cut the outer skin into small pieces, grind it in a mortar, put it into a 5000mL round bottom flask, and add it at a ratio of 1:2.5 to liquid Pure water 1250mL, according to the Chinese Pharmacopoeia Appendix XD method, extract the volatile oil components in the navel orange peel, adjust the heating temperature until there are liquid droplets dripping, and there must be a sufficient condensation effect. During the extraction process, as the amount of volatile oil increases, it will eventually flow into the round bottom flask. During the experiment, part of the volatile oil can be released first to improve the extraction efficiency. Extract for about 4-5 hours until the amount of volatile oil no longer increases, stop heating, and after standing for a period of time, rotate the piston to slowly release the oil layer to o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an active composition for mouth wash and the mouth wash. The composition is prepared from the following components in dosage: 0.01 to 1g of thymol, 0.02 to 2g of menthol, 0.05 to 5mL of eudesmol, 0.025 to 2.5 mL of methyl salicylate, 0.025 to 2.5 mL of orange peel essential oil and 0.002 to 0.2 g of sodium fluoride. The mouthwash disclosed by the invention has orange fragrance, is clear and transparent, has good heat-resistant and cold-resistant stability, the pH value is 6.80, the content of free fluorine and the content of soluble fluorine are measured to be 10.07 mg / 100mL and 11.10 mg / 100mL, the total number of bacterial colonies per milliliter is 10, and the mouthwash meets the industrial standard product quality requirement; bacteriostatic experiment results show that the mouthwash added with the natural active ingredients has a certain inhibition effect on staphylococcus aureus, the minimum inhibitory concentration of the orange peel essential oil is 11.5 mg / mL, the bacteriostasis rate is 63.67%, and various quality inspection indexes of the prepared natural orange peel essential oil mouthwash are qualified.

Description

technical field [0001] The invention relates to an active composition for mouthwash, a mouthwash and a preparation method thereof. Background technique [0002] Orange peel is the peel of Citrus reticulate Blanco and its cultivars. At present, the main consumption methods of navel oranges in my country are the sale of fresh fruit and the production of orange juice. According to the survey, a large amount of orange peels have not been developed and utilized in the process of processing and manufacturing navel orange related products, but are directly discarded or dried and then incinerated. This is a waste of resources. The waste of waste is also a pollution to the environment. The research on the comprehensive utilization of navel orange peel is not enough, a large amount of discarded navel orange peel is wasted, and it also pollutes the environment, so the research on the reuse of orange peel is of great significance. Navel orange peel has a fresh orange fruity aroma, main...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K8/92A61K8/21A61K8/34A61K8/37A61Q11/00A61P1/02A61P31/04
Inventor 黄浩刘海李林福孟宪生包永睿明良山胡海波杨建琼刘鸣徐颖肖瑶高进曹晖
Owner GANNAN MEDICAL UNIV