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Light-activated antibacterial dressing and preparation method thereof

A light-activated, heterojunction technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, inorganic active ingredients, etc., can solve the problem of non-existence of antibacterial effect, achieve excellent antibacterial effect, high feasibility, and low treatment cost

Active Publication Date: 2022-04-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, one of the purposes of the present invention is to provide a light-activated antibacterial dressing that can solve the problem that the antibacterial effect no longer exists in the existing light therapy method when the light source is removed

Method used

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  • Light-activated antibacterial dressing and preparation method thereof
  • Light-activated antibacterial dressing and preparation method thereof
  • Light-activated antibacterial dressing and preparation method thereof

Examples

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preparation example Construction

[0041] The present invention also provides a method for preparing the above-mentioned wound dressing for treating infected wounds, the method comprising the following steps:

[0042] S1. Etching MAX ceramics into MXene nanosheets.

[0043] Specifically, S11. First, immerse the MAX ceramic raw material in the etching solution, and keep stirring for 12-24 hours at a constant temperature of 37-45°C.

[0044] Wherein, the etching solution may be a mixture of lithium fluoride and hydrochloric acid solution. But the present invention is not limited thereto, and the direct product hydrofluoric acid can also be used. Compared with the use of finished hydrofluoric acid, this embodiment prepares the mixture of lithium fluoride and hydrochloric acid solution as the etching solution, which can avoid the transfer and dumping of hydrofluoric acid, which is safer and reduces the possibility of danger. sex.

[0045] MXene material is a new type of two-dimensional layered transition metal c...

example 1

[0100] Will 1gMAX(Ti 3 AlC 2 ) was immersed in an etching solution, which was a mixture of lithium fluoride (LiF, 1 g) and hydrochloric acid (HCl) solution (9M, 20 mL), and kept stirring at a constant temperature of 40° C. for 12 hours. Then, wash the precipitate with deionized water, centrifuge 7 times at 3500r / min, and the centrifugation time is 5min, 15min, 30min, 1h, 1h respectively. The sixth and seventh centrifugation was repeated for 1 h. The product was lyophilized at -20 °C to obtain etched MXene.

[0101] The MXene (0.1 g) obtained above was dispersed in distilled water, and 0.1 M silver nitrate (AgNO 3 ) solution 100mL, make Ag + Electrostatic adsorption on the surface of MXene. The resulting product was dialyzed overnight until the dialysate was free of Ag + For residues, check with sodium chloride. Then vigorously stir in the dialysate, and gradually add 0.05M silver phosphite (Na 2 HPO 4 ) aqueous solution. The precipitate was freeze-dried again to obta...

example 2

[0106] Will 1gMAX(Ti 3 AlC 2 ) was immersed in an etching solution, which was a mixture of lithium fluoride (LiF, 1 g) and hydrochloric acid (HCl) solution (9M, 20 mL), and kept stirring at a constant temperature of 40° C. for 12 hours. Then, wash the precipitate with deionized water, centrifuge 7 times at 4000r / min, the centrifugation time is 5min, 15min, 30min, 1h, 1h; repeat the sixth and seventh centrifugation for 1h. The product was lyophilized in a vacuum lyophilizer to obtain etched MXene.

[0107] The MXene (0.15g) obtained above was dispersed in distilled water, and 0.15M silver nitrate (AgNO 3 ) solution 100mL, make Ag + Electrostatic adsorption on the surface of MXene. The resulting product was dialyzed overnight until the dialysate was free of Ag + For residues, check with sodium chloride. Then vigorously stir in the dialysate, and gradually add 0.075M silver phosphite (Na 2 HPO 4 ) aqueous solution. The precipitate was freeze-dried again to obtain the pur...

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PUM

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Abstract

The invention provides a photo-activated antibacterial dressing and a preparation method thereof. The preparation method comprises the following steps: S1, etching MAX ceramic into MXene nanosheets; s2, an MXene / Ag3PO4 heterojunction is prepared, and the MXene / Ag3PO4 heterojunction is prepared; s3, modifying the MXene / Ag3PO4 heterojunction by using the polydopamine; and S4, dissolving the polycaprolactone particles and the polydopamine modified MXene / Ag3PO4 heterojunction, uniformly mixing, and forming a membrane, so as to obtain the nanofiber membrane. The wound dressing for treating infected wounds has the effects of quickly sterilizing in a short time, inhibiting bacteria for a long time and promoting wound healing.

Description

technical field [0001] The technical field of medical materials of the present invention, more specifically, relates to a light-activated antibacterial dressing and a preparation method thereof. Background technique [0002] As the largest organ and the first line of defense of the human body, the skin plays a vital role in protecting the internal environment of the body from external damage. Once the skin is damaged and loses its original defense function, the subcutaneous tissue will be invaded by microorganisms, leading to infection, bringing physical and mental pain to the patient, and even causing amputation or death. In addition, if the patient itself is accompanied by basic diseases, such as diabetes, it is easy to cause chronic wounds, and repeated treatments are also likely to cause the emergence of drug-resistant bacteria. [0003] At present, for the treatment of infected wounds, the method of debridement dressing is mostly used. However, traditional wound dress...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/26A61L15/42A61L15/46A61K41/00A61K33/38A61P31/04A61P17/02
CPCY02A50/30
Inventor 梁坤能杨英明陶思颖邓怡李继遥
Owner SICHUAN UNIV
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