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Fresh polygonatum odoratum freeze-dried decoction pieces and preparation method thereof

A Polygonatum Polygonatum and freeze-drying technology, which is applied in the field of traditional Chinese medicine, can solve problems such as cell damage and irritation, and achieve the effects of reducing calcium oxalate content, easy storage, and slowing down the rate of water sublimation

Pending Publication Date: 2022-04-29
江西纳弗堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Polygonatum polysaccharides are rich in Polygonatum polysaccharides and other substances, among which polysaccharides of Polygonatum polysaccharides have various functions such as lowering blood sugar, anti-aging, and anti-lipid peroxidation, but at the same time Polygonatum polysaccharides also contain a large amount of fixed calcium oxalate needle crystals, calcium oxalate needles Crystals can directly stimulate mucosal cells and cause cell damage, thereby producing a large amount of inflammatory mediators, causing irritation and even pain. Therefore, during the processing of Polygonatum odoratum, it is necessary to remove calcium oxalate needle crystals in Polygonatum odoratum as much as possible

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method for freeze-dried decoction pieces of fresh Polygonatum odoratum comprises the following steps:

[0027] Step 1: After washing and removing impurities from the fresh Polygonatum odoratum, cut the thick slices into 0.6mm thick slices, put the thick slices into the acetic acid solution containing sesame oil for ultrasonic impregnation, take them out and dry them, and dry them in a nitrogen-filled oven with a drying wind speed of 8m / s; get the first crude product; the mass ratio of the sesame oil and the acetic acid solution is 1:1, and the concentration of the acetic acid solution is 10wt%;

[0028] Step 2: Put the first crude product into a fermentation broth containing oxalate decarboxylase for fermentation, ferment for 10 hours, and filter to obtain the second crude product;

[0029] Step 3: freeze-drying the second crude product under vacuum conditions to obtain the third crude product;

[0030] The preparation method of the fermented liquid is a...

Embodiment 2

[0033] A preparation method for freeze-dried decoction pieces of fresh Polygonatum odoratum comprises the following steps:

[0034] Step 1: After washing and removing impurities from the fresh Polygonatum odoratum, cut into 0.6mm thick slices, put the thick slices into acetic acid solution containing sesame oil for ultrasonic impregnation, take out and dry, and dry in a nitrogen-filled oven with a drying wind speed of 9m / s; get the first crude product; the mass ratio of the sesame oil and the acetic acid solution is 1:2, and the concentration of the acetic acid solution is 10wt%;

[0035] Step 2: putting the first crude product into a fermentation broth containing oxalate decarboxylase for fermentation, and obtaining the second crude product after the fermentation;

[0036] Step 3: freeze-drying the second crude product under vacuum conditions to obtain the third crude product;

[0037] The preparation method of the fermented liquid is as follows: dissolving oxalate decarbox...

Embodiment 3

[0040] A preparation method for freeze-dried decoction pieces of fresh Polygonatum odoratum comprises the following steps:

[0041] Step 1: After washing and removing impurities from the fresh Polygonatum odoratum, cut the thick slices into 0.8mm thick slices, put the thick slices into the acetic acid solution containing peanut oil for ultrasonic impregnation, take them out and dry them, and dry them in a nitrogen-filled oven with a drying wind speed of 9m / s; get the first crude product; the mass ratio of described peanut oil and acetic acid solution is 1:3, and the concentration of acetic acid solution is 12wt%;

[0042] Step 2: putting the first crude product into a fermentation broth containing oxalate decarboxylase for fermentation, and obtaining the second crude product after the fermentation;

[0043] Step 3: freeze-drying the second crude product under vacuum conditions to obtain the third crude product;

[0044] The preparation method of the fermented liquid is as fo...

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PUM

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Abstract

The invention discloses a fresh polygonatum odoratum freeze-dried decoction piece and a preparation method thereof, and relates to the field of traditional Chinese medicine, the fresh polygonatum odoratum is cleaned to remove impurities, the cleaned fresh polygonatum odoratum is cut into thick pieces, the thick pieces are placed in an acidic soak solution containing vegetable oil for ultrasonic impregnation, and the thick pieces are taken out and dried to obtain a first crude product; the first crude product is put into fermentation liquor containing oxalate decarboxylase to be fermented, and a second crude product is obtained after fermentation is finished; the second crude product is subjected to freeze drying under the vacuum condition, and a third crude product is prepared. According to the fresh polygonatum odoratum freeze-dried decoction piece, the content of calcium oxalate in the fresh polygonatum odoratum freeze-dried decoction piece is reduced, and meanwhile the dried decoction piece is not prone to embrittlement and easy to store.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a freeze-dried decoction piece of fresh Polygonatum odoratum and a preparation method thereof. Background technique [0002] The dry rhizome of Polygonatum Polygonatum is long cylindrical, slightly flat, with few branches, 4-18cm long, 0.3-1.6cm in diameter, yellow-white or light yellow-brown surface, translucent, with longitudinal wrinkles and slight The raised link has white dot-shaped fibrous root scars and disc-shaped stem scars, hard and brittle or slightly soft, easy to break, cuticle-like or granular, slightly odorous, sweet, sticky when chewed, and Sweet in taste, slightly cold; returns to lung and stomach meridians; nourishes yin and moistens dryness, produces body fluid and quenches thirst; used for lung and stomach yin injury, dry-heat cough, dry throat and thirst, internal heat and quenching thirst. [0003] Polygonatum polysaccharides are rich in Polygona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K125/00
CPCA61K36/8969A61K2236/19A61K2236/17A61K2236/10A61K2236/15
Inventor 宋细忠李小丽李金林简建敏习梅兰刘四英钱丽梅陈述耀
Owner 江西纳弗堂制药有限公司
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