Polyhydroxyalkanoate tablet as well as preparation method and application thereof

A technology of polyhydroxyalkanoate and polyhydroxyalkanoate, which is applied in the field of degradable material processing, can solve the problems of reduced molecular weight, incomplete tablet form, poor fluidity, etc., achieve increased fluidity and viscosity, improve the difficulty of cutting, High formability effect

Active Publication Date: 2022-05-10
MEDPHA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] P-3HB, but the polyhydroxyalkanoate obtained after being extracted from the cells and washed and dried is in powder form. The powder raw material is not conducive to the existing processing technology, storage, transportation and use, and its efficiency and utilization are higher than that of granular or tablet low raw material
And at present, the preparation technology of polyhydroxyalkanoate tablet mainly has following problems: (1) often adopt screw extruder or other heating machine to process polyhydroxyalkanoate powder, but because the processing of polyhydroxyalkanoate The window is sensitive and narrow, so the high temperature will cause the molecular chain of the long chain of polyhydroxyalkanoate to be cracked, degraded, and the molecular weight will be reduced, thereby affecting the material properties of polyhydroxyalkanoate; During the tablet machine (cold pressing process), due to the extremely poor fluidity of the polyhydroxyalkanoate powder, the form of the cold-pressed tablet is incomplete, and the force is easily dispersed, resulting in the polyhydroxyalkanoate during storage and transportation. Acid ester tablets will disperse into powder

Method used

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  • Polyhydroxyalkanoate tablet as well as preparation method and application thereof
  • Polyhydroxyalkanoate tablet as well as preparation method and application thereof
  • Polyhydroxyalkanoate tablet as well as preparation method and application thereof

Examples

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Embodiment

[0047] The polyhydroxyalkanoate used in the present invention was purchased from Mai Defa Biotechnology Co., Ltd., maltodextrin was purchased from Shandong Zhengyu Chemical Co., Ltd., carboxymethyl starch was purchased from Guangdong Hongxin Biotechnology Co., Ltd., and octenyl succinate Acid starch esters were purchased from Candice Chemicals.

[0048] The dosages of the components of Examples 1-5 and Comparative Examples 1-4 in the present invention are shown in Table 1.

[0049] Table 1 (unit: parts by weight)

[0050]

[0051] The preparation method of the polyhydroxyalkanoate tablet of embodiment 1-5 and comparative example 1-4 is as follows:

[0052] Firstly, each component is pretreated, put into a vacuum microwave oven for drying, so that the moisture content of the powder material does not exceed 0.5%. Then put the above components into the three-dimensional mixer according to the proportion and mix them evenly. Put the above-mentioned uniformly mixed powder int...

Embodiment 1

[0075] Embodiment 1 and comparative example 4 contrast calcium carbonate and magnesium stearate to the influence of tablet appearance, experiment proves that adopting calcium carbonate and magnesium stearate can improve the appearance of tablet while keeping tablet and hardness, makes tablet The appearance is smoother. And it is good for demoulding during processing, and it is convenient for cold pressing processing.

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Abstract

The invention relates to the technical field of degradable material processing, and particularly discloses a polyhydroxyalkanoate tablet as well as a preparation method and application thereof, and the polyhydroxyalkanoate tablet comprises the following components: polyhydroxyalkanoate, maltodextrin, carboxymethyl starch, octenyl succinic acid modified starch and a lubricant. The prepared polyhydroxyalkanoate tablet has high hardness and strength, low friability and smooth surface, the form of the tablet is beneficial to subsequent processing, use, storage and transportation, a cold pressing process is adopted in the preparation process, and the performance of polyhydroxyalkanoate is not affected.

Description

technical field [0001] The invention belongs to the technical field of degradable material processing, and in particular relates to a polyhydroxyalkanoate tablet, a preparation method and application thereof. Background technique [0002] Polyhydroxyalkanoate is a natural polymer biomaterial, which is a kind of intracellular polyester synthesized by microorganisms. By changing the strains, carbon source types and technological conditions during the cultivation process, different structures can be produced by fermentation. And performance polyhydroxyalkanoate materials, such as poly-3-hydroxybutyrate (P-3HB), poly-4-hydroxybutyrate (P-4HB), poly-3-hydroxybutyrate valerate ( PHBV), poly-3-hydroxybutyrate hexanoate (PHBH), poly-3-hydroxybutyrate-4-hydroxybutyrate P (3HB-co-4HB), etc., to meet the needs of different industries. Polyhydroxyalkanoate has good biocompatibility and biodegradability at the same time, so it can be used to prepare biodegradable plastics. [0003] P-3...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L3/02C08L1/28C08L3/06C08K3/26C08K5/098
CPCC08L67/04C08L2201/06C08L3/02C08L1/286C08L3/06C08K3/26C08K5/098
Inventor 余岳明刘志伟吕金艳司徒卫余柳松
Owner MEDPHA CO LTD
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