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Composition capable of enhancing anti-dentin hypersensitivity effect of bioactive material as well as preparation method and application of composition

A bioactive, bioactive glass technology, applied in the field of compositions that can enhance the anti-dentin sensitivity effect of bioactive materials, can solve problems affecting the contact and deposition of functional components

Pending Publication Date: 2022-05-27
CHONGQING DENCARE CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex surface of living teeth, the contact and deposition of functional ingredients on the tooth surface are greatly affected, and the formation of the sealant requires a certain reaction time, and its anti-allergic effect will only be reflected after long-term action

Method used

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  • Composition capable of enhancing anti-dentin hypersensitivity effect of bioactive material as well as preparation method and application of composition
  • Composition capable of enhancing anti-dentin hypersensitivity effect of bioactive material as well as preparation method and application of composition
  • Composition capable of enhancing anti-dentin hypersensitivity effect of bioactive material as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] A preparation method of a toothpaste containing a composition that can enhance the anti-dentin sensitivity effect of a biologically active material, comprising the following steps:

[0040] Step 1: add humectant, then add adhesive, stir to homogenize, add sweetener and stir evenly to obtain system 1;

[0041] Step II: add friction agent, soaked bioactive material, tea polyphenols, foaming agent into system I and stir to obtain system II;

[0042] Step III: adding essence into system II, stirring to homogenize and degassing, the toothpaste is finished.

[0043] Example 1-Example 4 are examples of the present invention, Comparative Example 1-Comparative Example 12 are comparative examples of the present invention, and the difference between each embodiment and Comparative Example is the selection of raw materials and the amount of addition, see Table 1 for details , wherein the biologically active materials of Examples 1-4 and Comparative Examples 1-5 have been soaked in...

experiment example 1

[0053] Experimental example 1: In vitro remineralization repair test of demineralized dentin

[0054] The in vitro remineralization repair effect of the toothpaste prepared by the above-mentioned embodiments and comparative examples is verified, and the test method is as follows:

[0055] Artificial saliva (ISO / TR10271 standard) preparation: sodium chloride (NaCl) 0.4g, potassium chloride (KCl) 0.4g, calcium chloride dihydrate (CaCl) 2 ·2H 2 O) 0.795g, sodium dihydrogen phosphate dihydrate (NaH 2 PO4·2H 2 O) 0.78g, sodium sulfide dihydrate (Na 2 S·2H 2 O) 0.005 g, urea (Urea) 1 g, diluted to 1000 ml with deionized water (distilled water), pH 6.8.

[0056] Preparation of dentin specimens: Select fresh bovine central incisors, separate the tooth roots along the cementoenamel boundary with a low-speed diamond cutter (SYJ-150), and polish and polish the tooth bones with 600, 800 and 2000 grit sandpaper in turn. Plasma, which exposes the dentin.

[0057] Acid etching of dent...

experiment example 2

[0066] Experimental example 2: Stability test of tea polyphenols in anhydrous toothpaste

[0067] In order to verify the stable preservability of the tea polyphenols of the toothpaste of the present invention in an anhydrous formula system, toothpastes with water (Comparative Example 5) and anhydrous formula (Example 1) were prepared; the specific formulas are shown in Table 1.

[0068] Aspirate 1mL of the test solution, put it in a 25mL volumetric flask, add 4mL of water and 5mL of ferric tartrate solution, shake well, dilute to the mark with pH=7.5 phosphate buffer, replace the test solution with water and add the same reagent as a blank. Absorbance was measured with a wavelength of 540 nm and a 0.5 cm cuvette.

[0069] Calculation: content of tea polyphenols (mg g -1 )=A×7.826(1 / V 1 )×V 2 ×(1 / 1000)×(1 / m)×100, where: A- absorbance value of sample solution; V 1 -Amount of test solution sucked (mL); V 2 -Total amount of the test solution (mL); m-Weigh the sample mass (g)....

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Abstract

The invention relates to the field of oral care products, and discloses a composition capable of enhancing the dentin hypersensitivity resisting effect of a biological active material and a preparation method and application thereof.The composition is prepared from, by mass, 1-10 parts of the biological active material and 0.0001-0.5 part of tea polyphenol; the bioactive material is soaked in polyethylene glycol before being used. The composition can be used as an oral care product anti-sensitive agent. The tea polyphenol and the bioactive material are compounded and applied to the anhydrous formula system toothpaste, the stability and activity of the tea polyphenol can be enhanced, the effect of relieving related gingival problems is achieved, and meanwhile the dentin hypersensitivity resisting effect of the bioactive material can be greatly synergistically enhanced.

Description

technical field [0001] The invention relates to the field of oral care products, in particular to a composition capable of enhancing the anti-dentin sensitivity effect of a biologically active material and a preparation method and application thereof. Background technique [0002] Dentinal hypersensitivity (DH) refers to the transient, sharp pain or discomfort that occurs when exposed dentin is stimulated by mechanical, chemical, temperature, osmotic pressure, etc. Other types of dental disease. The pathogenesis of dentin hypersensitivity is not very clear. There are three main theories explaining the perception and transmission mechanism of dentin pain: nerve fiber conduction theory, dentin fiber conduction theory, and fluid dynamics theory. Among them, the most widely accepted is the hydrodynamic theory, which holds that various stimuli acting on the surface of the dentinal tubules will cause the expansion or contraction of the fluid in the dentinal tubules, thereby causi...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/49A61K8/19A61Q11/00A61P1/02A61P31/02A23G4/06
CPCA61K8/9789A61K8/498A61K8/19A61Q11/00A61P1/02A61P31/02A23G4/064A23G4/06A61K2800/592A23V2002/00A23V2200/312A23V2250/15A23V2250/2132Y02A50/30
Inventor 董海德张环蔡开勇杨维虎邓全富尹利娟唐伟月邓嵘
Owner CHONGQING DENCARE CORP
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