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Topirolast medicine and preparation method thereof

A technology for topirast and drugs, applied in the field of topirast drugs, can solve the problems of adding many excipients and insufficient antiseptic effect, and achieve the effects of proper matching, easy cost control, and improved taste

Pending Publication Date: 2022-05-31
GUANGDONG JIUMING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of levocetirizine hydrochloride oral drops and preparation method thereof, to solve the problems of insufficient antiseptic effect and numerous auxiliary materials in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Topirast medicine, in parts by weight, includes the following ingredients: 18 parts of topirast, 20 parts of lactose monohydrate, 19 parts of microcrystalline cellulose, 2 parts of hydroxypropyl cellulose, cross-linked carboxymethyl cellulose 2.5 parts of sodium, 1 part of magnesium stearate.

[0031] A preparation method of topirast medicine, the steps comprising:

[0032] (1) The bulk drug topirast is mechanically pulverized to remove large agglomerates, and then jet pulverized into a powder with a particle size of less than 10 μm;

[0033] (2) Weigh topiralast, lactose monohydrate, microcrystalline cellulose, hydroxypropyl cellulose, and croscarmellose sodium and place them in a wet granulator to stir, shear, mix and stir 6r / s, and shear Cut 15r / s, mix 5min;

[0034] (3) Granulation: add purified water to the granulated material obtained by mixing in the previous step as a wetting agent, the amount of purified water added is 37.5% of the granulated material, and th...

Embodiment 2

[0041] Topirast medicine, by weight part, comprises following composition:

[0042] 20 parts of topiralast, 25 parts of lactose monohydrate, 20.6 parts of microcrystalline cellulose, 1.9 parts of hydroxypropyl cellulose, 1.8 parts of croscarmellose sodium, and 0.7 parts of magnesium stearate.

[0043] The preparation method is the same as in Example 1.

Embodiment 3

[0045] Topirast medicine, by weight part, comprises following composition:

[0046] 22 parts of topiralast, 28 parts of lactose monohydrate, 22 parts of microcrystalline cellulose, 1.5 parts of hydroxypropyl cellulose, 2.5 parts of croscarmellose sodium, and 1 part of magnesium stearate.

[0047] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a topiromilast medicine and a preparation method thereof, the topiromilast medicine comprises the following components: topiromilast, lactose monohydrate, microcrystalline cellulose, hydroxy propyl cellulose, croscarmellose sodium and magnesium stearate, and the preparation process comprises the steps of raw material medicine treatment, wet granulation, wet size stabilization, drying, dry size stabilization, total mixing and tabletting. According to the tablet with the topirolast as the functional component, one more choice can be provided for drugs for treating hyperuricemia and gout; auxiliary materials are properly matched, so that the medicine taking taste can be improved, and the medicine is easily absorbed by organisms; the preparation process is simple, easy in cost control and suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to topiralast. Background technique [0002] Gout is a kind of crystalline arthritis caused by purine metabolism disorder and / or decreased uric acid excretion. The clinical manifestations are characteristic acute arthritis, tophi formation, and tophi Chronic arthritis etc. Topirast is a selective xanthine oxidase inhibitor with no purine structure. It has a significant effect on reducing uric acid and has high safety. It can be used to treat gout and hyperuricemia. The development of a drug whose active ingredient is topirast is of great significance for the treatment of hyperuricemia and gout. Contents of the invention [0003] The object of the present invention is to provide a kind of levocetirizine hydrochloride oral drops and preparation method thereof, to solve the problems of insufficient antiseptic effect and numerous auxiliary materials in the prior ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/444A61K47/38A61K47/26A61K47/12A61P19/06
CPCA61K31/444A61K9/2054A61K9/2018A61K9/2013A61P19/06
Inventor 管小明
Owner GUANGDONG JIUMING PHARMA
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