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Preparation for treating piglet yellow-white dysentery through combination of smoked plums and trimethoprim and preparation method of preparation

A technology for piglet yellow and white diarrhea and trimethoprim, which is applied in the preparation field of ebony and trimethoprim for treating piglets' yellow and white diarrhea and the field of preparation thereof, can solve the problems of generation of drug-resistant bacteria, low drug dosage, poor therapeutic effect and the like, and achieves Guarantee the therapeutic effect, improve compliance, improve the effect of curative effect

Pending Publication Date: 2022-05-31
广西农业职业技术大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing treatment plan for yellow and white scours of piglets is mainly antimicrobial drug treatment, the therapeutic effect is poor if the dosage is small, and the drug-resistant bacteria will easily be produced if the dosage is too large. Pyridine is an antibacterial drug that is not easily absorbed by the intestinal tract, and it is difficult to exert its medicinal effect when used alone. Therefore, the research and development of traditional Chinese medicine has been strengthened, and traditional Chinese medicine with excellent antibacterial effect has been screened out to replace antibacterial drugs. a new idea

Method used

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  • Preparation for treating piglet yellow-white dysentery through combination of smoked plums and trimethoprim and preparation method of preparation
  • Preparation for treating piglet yellow-white dysentery through combination of smoked plums and trimethoprim and preparation method of preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A preparation of ebony plum combined with trimethoprim for treating yellow and white scour of piglets, which is made of the following raw materials in parts by weight: 200 parts of ebony extract, 0.1 part of trimethoprim, 1 part of compound probiotics and 50 parts of auxiliary materials; Composed of gum arabic, γ-cyclodextrin, chitosan and ethyl cellulose, the weight ratio of gum arabic, γ-cyclodextrin, chitosan and ethyl cellulose is 10:15:5:3 parts; compound probiotics are composed of Bifidobacterium longum, Bacillus velesii and Enterococcus with the number ratio of live bacteria 1:0.5:0.5.

[0027] The extraction method of the ebony extract is as follows: after removing the core of the ebony, weigh 60 parts of the ebony meat, add 10 times of water, decoct with a slow fire for 20 minutes, then filter while it is hot, and concentrate to 400mL to obtain ebony with a crude drug concentration of 166mg / mL Extract; the storage temperature of ebony extract is 4°C.

[0028] ...

Embodiment 2

[0033] A preparation of ebony plum combined with trimethoprim for treating yellow and white scour of piglets, which is made of the following raw materials in parts by weight: 500 parts of ebony extract, 0.15 parts of trimethoprim, 10 parts of compound probiotics and 100 parts of auxiliary materials; Composed of gum arabic, γ-cyclodextrin, chitosan and methylcellulose, the weight ratio of the gum arabic, γ-cyclodextrin, chitosan and methylcellulose is 10:35:15:8 servings; compound probiotics are composed of Bifidobacterium longum, Bacillus velesii and Enterococcus with the number ratio of live bacteria 1:5:5.

[0034] The extraction method of the ebony extract is as follows: after removing the core of the ebony, weigh 100 parts of the ebony meat, add 20 times of water, decoct with a slow fire for 60 minutes, then filter while it is hot, and concentrate to 600mL to obtain ebony with a crude drug concentration of 150mg / mL Extract; the storage temperature of ebony extract is 8°C. ...

Embodiment 3

[0040] This embodiment is consistent with other process parameters of Example 1, except that: 300 parts of ebony extract, 3 parts of trimethoprim, 3 parts of compound probiotics and 70 parts of auxiliary materials; Composed of dextrin, chitosan and hypromellose, the weight ratio of the gum arabic, γ-cyclodextrin, chitosan and hypromellose is 10:20:8:4 parts.

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Abstract

The invention discloses a preparation for treating piglet yellow-white dysentery by combining smoked plum with trimethoprim. The preparation is prepared from the following raw materials in parts by weight: 200-500 parts of smoked plum extracting solution, 0.1-1 part of trimethoprim, 1-10 parts of compound probiotics and 50-100 parts of auxiliary materials, the auxiliary material is composed of Arabic gum, gamma-cyclodextrin, chitosan and an adhesive, and the weight ratio of the Arabic gum to the gamma-cyclodextrin to the chitosan to the adhesive is 10: (15-35): (5-15): (3-8). The synergistic effect of the smoked plums and the trimethoprim is exerted, the enrichment effect of the smoked plums is promoted, meanwhile, the trimethoprim is an antibacterial medicine which is not prone to being absorbed by intestinal tracts, the absorption of the intestinal tracts of piglets to the trimethoprim is promoted by adding the compound probiotics composed of bifidobacterium longum, bacillus velezensis and enterococcus, and the absorption of the intestinal tracts of the piglets to the trimethoprim is promoted. The treatment effect on the yellow-white dysentery of the piglets is ensured, and the composition is green and free of residues.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation of black plum combined with trimethoprim for treating yellow and white scour of piglets and a preparation method thereof. Background technique [0002] Piglet diarrhea is the most common disease that has been affecting the development of the pig industry. There are various pathogenic factors, including nutritional factors, viral infections and bacterial infections. Among them, Escherichia coli infection is recognized as the main cause of yellow and white scour in piglets. Escherichia coli is also an opportunistic pathogen, which mainly causes severe diarrhea and fever after infection, leading to dehydration shock and death of piglets. The incidence and mortality of piglets with different feeding levels are quite different, with an average incidence of about 35% and an average mortality of 15.5%. Effective control of Escherichia coli infection can great...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/16A61K47/69A61P31/04A61P1/12A61K31/505A61K35/742A61K35/744A61K35/745
CPCA61K36/736A61K31/505A61K35/745A61K35/742A61K35/744A61K47/6951A61K47/6949A61K9/1652A61P31/04A61P1/12A61K2300/00Y02A50/30
Inventor 谢江陆有飞王小玲陆集成
Owner 广西农业职业技术大学
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