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Methyl methacrylate copolymer microsphere encapsulated with initiator, preparation method and injectable bone cement

A technology of methyl methacrylate and copolymers, which can be used in drug delivery, pharmaceutical formulations, prostheses, etc., and can solve problems such as unfavorable clinical operations for doctors, necrosis, and short curing time of PMMA bone cement.

Pending Publication Date: 2022-05-31
DABO MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When mixing, the initiator in the powder and the activator in the liquid directly contact and dissolve together to form an oxidation-reduction system to initiate free radical polymerization of MMA at room temperature, and the premature start of free radical polymerization leads to the working time of the bone cement Short, not conducive to the doctor's clinical operation
At the same time, the heat release of bone cement polymerization is concentrated, and the violent polymerization reaction causes the local transient temperature of bone cement to exceed the tolerance range of human tissues, which in turn causes thermal damage or even necrosis of surrounding tissues.
Therefore, there is an urgent need to solve the two problems of short curing time of PMMA bone cement and high exothermic temperature during curing.

Method used

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  • Methyl methacrylate copolymer microsphere encapsulated with initiator, preparation method and injectable bone cement
  • Methyl methacrylate copolymer microsphere encapsulated with initiator, preparation method and injectable bone cement
  • Methyl methacrylate copolymer microsphere encapsulated with initiator, preparation method and injectable bone cement

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Effect test

Embodiment 1

[0048] One, the preparation of the methyl methacrylate copolymer microsphere of encapsulation initiator:

[0049] S1, preparation of methyl methacrylate copolymer suspension containing initiator:

[0050] Under the condition of rotating speed of 400r / min, 2 parts of hydroxyethyl cellulose was added into 500 parts of deionized water and stirred to dissolve. After the hydroxyethyl cellulose is completely dissolved, add 5 parts of dibenzoyl peroxide (BPO) with a mass fraction of 75% and 300 parts of methyl methacrylate monomer, raise the temperature to 80°C and keep it warm for 60 minutes, then raise the temperature To 92 ℃ ~ 95 ℃ and continue to keep warm for 30 minutes. The resulting suspension was cooled to room temperature to obtain a methyl methacrylate copolymer suspension slurry. After analysis, the solid content in the obtained methyl methacrylate copolymer suspension slurry was 37.5%, and the residual amount of BPO was 0.86%.

[0051] S2, preparation of methyl methacr...

Embodiment 2

[0066] One, the preparation of the methyl methacrylate copolymer microsphere of encapsulation initiator:

[0067] S1, preparation of methyl methacrylate copolymer suspension containing initiator:

[0068] With the method of S1 among the embodiment 1.

[0069] S2, preparation of methyl methacrylate homopolymer emulsion:

[0070] S2.1 Preparation of monomer emulsion:

[0071] Add methyl methacrylate, deionized water, and sodium lauryl sulfate into a round-bottomed flask at a ratio of 100:30:0.5, and keep stirring evenly to prepare a mixed monomer emulsion.

[0072] S2.2 Preparation of methyl methacrylate homopolymer emulsion:

[0073] Add 125 parts of deionized water into a four-neck flask equipped with a reflux tube, a thermometer, an addition funnel and a stirrer, heat it in a water bath to 80°C, and fill it with nitrogen for protection at a speed of 150r / min. Add 50 parts of the monomer emulsion prepared by S2.1 into a four-necked bottle, then add 10 parts of 2wt% potassi...

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Abstract

The invention relates to an initiator-encapsulated methyl methacrylate copolymer microsphere, a preparation method and injectable bone cement. When the initiator-encapsulated methyl methacrylate copolymer microsphere is applied to injectable bone cement, the initiator-encapsulated methyl methacrylate copolymer microsphere is gradually wetted and dissolved by a monomer, the initial viscosity of bone cement slurry is gradually changed in the dissolving process, the degree of polymerization reaction is relatively gentle, and the injectable bone cement is more stable. And the heat release temperature is obviously reduced, so that the operation time in the clinical use process can be effectively prolonged, and the heat injury to tissues can be improved.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials in the field of biomedical engineering, in particular to a methyl methacrylate copolymer microsphere encapsulating an initiator, a preparation method and an injectable bone cement. Background technique [0002] Polymethyl methacrylate (PMMA) bone cement has the advantages of good mechanical properties and can be made into any shape. It is widely used in vertebroplasty to treat vertebral compression fractures. It can quickly stabilize the damaged vertebral body. Relieve the patient's symptoms. In particular, the injectable polymethyl methacrylate bone cement is easy to operate, causes little damage to the patient's tissue, shortens the healing time, relieves the pain of the patient, and adapts to the development of minimally invasive surgical techniques. [0003] Injectable polymethyl methacrylate bone cement generally consists of one part liquid and one part powder in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08L33/12C08K5/14C08F120/14C08F220/14C08F2/20C08F2/26A61L27/16A61L27/50
CPCC08J3/126C08F120/14C08F220/14C08F2/20C08F2/26A61L27/16A61L27/50C08J2333/12C08J2433/12C08K5/14A61L2400/06A61L2430/02Y02E60/10
Inventor 蔡仁钦曾达林意华时瑞唐建华
Owner DABO MEDICAL TECH CO LTD
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