Method for preparing n-butyl thiourea

Abstract

The invention discloses a method for preparing butyl thiourea, which comprises the following steps: (1) dissolving and mixing tert-butyl alcohol and ammonium thiocyanate with water to obtain a homogeneous solution A; (2) simultaneously pumping the homogeneous solution A and a hydrochloric acid solution into a microreactor amp; the method comprises the following steps: carrying out reaction and extraction in an extraction device I, and collecting an organic phase liquid, namely a mixture of tert-butyl thiocyanate and tert-butyl isothiocyanate, namely mixed ester for short; (3) pumping the obtained mixed ester into a microreactor II immobilized with a catalyst, reacting, and collecting effluent liquid, namely tert-butyl isothiocyanate which is abbreviated as isoester; (4) dissolving the obtained isoester in a first organic solvent to obtain a homogeneous solution B; dissolving isopropylamine in a second organic solvent to obtain a homogeneous solution C; and (5) respectively and simultaneously pumping the homogeneous solution B and the homogeneous solution C into a microreactor III, reacting, collecting an effluent liquid, and carrying out post-treatment to obtain the butyl thiourea. The method improves the heat and mass transfer efficiency, and is safe, efficient and energy-saving.

Description

technical field [0001] The invention belongs to the technical field of butylpropylthiourea synthesis, and in particular relates to a method for preparing butylpropylthiourea. Background technique [0002] Butyl thiourea, the full name of 1-isopropyl-3-tert-butyl thiourea, is a key intermediate in the synthesis of pesticide thiazide. Thiazinone, also known as pyridoxine, was developed by a Japanese pesticide company in the 1980s. It is a kind of pesticide that can effectively prevent and control pests such as rice planthoppers, leafhoppers, tea leafhoppers, and citrus spiny scales. Insecticide. The application and demand of the insecticide promethazine are highly related to the development of agricultural economy, especially the development of rice and other crop planting industries. At present, my country's loxacin products are mainly exported to Thailand, Singapore, Malaysia, Vietnam, Myanmar and other regions. Most of these regions are regions with developed agricultural...

AI Technical Summary

Problems solved by technology

The traditional production and preparation methods mostly adopt batch production process, (1) the operation steps are complicated, the yield loss is high (2) the heat and mass transfer efficiency of mixing and reaction is low, the production time is long, and it is difficult to control; (3) the production personnel and Materials and equipment cannot be isolated, which increases safety hazards in the production process

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