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Coating liquid composition for film-coated rubber plug, method for preparing coating liquid through esterification reaction, coating liquid, film-coated rubber plug and preparation method of film-coated rubber plug

A technology of coating glue and coating liquid, which is applied to the device and coating of the surface coating liquid, which can solve the problems of easy peeling off of the film and weak adhesion of the film material, and reduce particle pollution and surface friction. Low coefficient, effect of protecting drug stability

Active Publication Date: 2022-06-21
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a coating solution for film-coated rubber stoppers in order to overcome the problems of weak adhesion of film materials and easy shedding of the film in the prior art, and the defect that residual silicone oil will be released from the rubber stopper Composition, method for preparing coating liquid by esterification reaction, coating liquid, film-coated rubber plug and preparation method thereof, the film-coated rubber plug has better adhesion because the film on its surface does not fall off, and is compatible with hydrochloric acid Better resistance to chlorpromazine

Method used

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  • Coating liquid composition for film-coated rubber plug, method for preparing coating liquid through esterification reaction, coating liquid, film-coated rubber plug and preparation method of film-coated rubber plug
  • Coating liquid composition for film-coated rubber plug, method for preparing coating liquid through esterification reaction, coating liquid, film-coated rubber plug and preparation method of film-coated rubber plug
  • Coating liquid composition for film-coated rubber plug, method for preparing coating liquid through esterification reaction, coating liquid, film-coated rubber plug and preparation method of film-coated rubber plug

Examples

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Embodiment approach

[0064] According to a preferred embodiment of the present invention, the conditions for the ultraviolet light curing include: the power of the medium pressure mercury lamp is 300-2000W, the irradiation distance is 10-50cm, and the curing time is 60-300s. In the present invention, the ultraviolet light curing can be carried out in an inert atmosphere or an oxygen-containing atmosphere, and in order to reduce the production cost, the ultraviolet light curing is carried out in the air. In this preferred embodiment, the rubber stopper cured by ultraviolet light has a lower surface friction coefficient, and has better anti-ultraviolet, chemical resistance and aging resistance.

[0065] According to the present invention, the material of the rubber stopper to be sprayed is selected from at least one of isoprene rubber, butyl rubber and halogenated butyl rubber.

[0066] According to a particularly preferred embodiment of the present invention, the method for preparing a coating liqu...

Embodiment 1

[0097] This example is to illustrate the use of the film coating composition of the present invention to prepare a coating liquid, and the use of the coating liquid to prepare a film-coated rubber stopper. Specifically, it includes the steps of preparing the coating composition to obtain a coating liquid, coating the coating liquid on the surface of the cleaned and dried rubber plug, and photocuring the coating.

[0098] The material of the film-coated rubber plug in this embodiment is bromobutyl rubber.

[0099]The composition of the coating composition is: 100 g of alkoxy silicone oil, 100 g of acrylic acid, 2 g of H-type beta molecular sieve catalyst (silicon-aluminum molecular molar ratio of 25, cylindrical shape), 2 g of p-diphenol, 250 g of toluene, and 250 g of xylene.

[0100] Wherein, the preparation method of coating liquid comprises:

[0101] (1) by above-mentioned weight proportioning alkoxy silicone oil, acrylic acid, H-type beta molecular sieve catalyst and p-di...

Embodiment 2-7

[0112] This example is to illustrate the use of the film coating composition of the present invention to prepare a coating liquid, and the use of the coating liquid to prepare a film-coated rubber stopper.

[0113] The film-coated composition, the coating liquid and the film-coated rubber stopper were prepared in the same manner as in Example 1, except that the components and component contents in the film-coated composition, the components in the coating liquid and the The component contents and preparation conditions were changed, as shown in Table 1 and Table 2.

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Abstract

The invention relates to the technical field of medicinal rubber plug production, and discloses a coating liquid composition for a film-coated rubber plug, a method for preparing a coating liquid through esterification reaction, the coating liquid, the film-coated rubber plug and a preparation method of the film-coated rubber plug. The coating liquid composition contains hydroxyl silicone oil, acrylic acid, a catalyst, a polymerization inhibitor and an organic solvent; the catalyst is a molecular sieve catalyst; relative to 100 parts by weight of the hydroxyl silicone oil, the content of the acrylic acid is 60-400 parts by weight, the content of the catalyst is 0.1-3 parts by weight, the content of the polymerization inhibitor is 0.1-3 parts by weight, and the content of the organic solvent is 200-2000 parts by weight. The film-coated rubber plug is low in surface friction coefficient, and the film on the surface of the film-coated rubber plug does not fall off, so that the film-coated rubber plug has better adhesive force and has better resistance to chlorpromazine hydrochloride.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical rubber stopper production, in particular to a coating liquid composition for film-coated rubber stoppers, a method for preparing a coating liquid by esterification, and a film-coated rubber stopper prepared by the method A coating liquid, a film-coated rubber stopper and a preparation method thereof are provided. Background technique [0002] In the process of rubber stopper production, rubber stopper manufacturers often siliconize the rubber stopper. The lubricity of silicone oil can prevent the rubber stopper from sticking during production and transportation. [0003] However, the technical defect brought by silicification treatment is that after the medicine is filled, it needs to be sterilized with a plug, and the residual silicone oil will be released from the rubber stopper and dissolved into the medicine; in addition, silicification will also cause insoluble particles and visible fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D183/06C08G77/38B05D7/24B05D7/02
CPCC09D183/06C08G77/38B05D7/24B05D7/02
Inventor 李建华钟林安婷婷王镭宋小飞
Owner CHINA PETROLEUM & CHEM CORP
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