Bacterial cellulose-based photosensitive antibacterial dressing as well as preparation method and application thereof

A technology of bacterial cellulose and photosensitizer, applied in the field of biomedical nanomaterials, can solve the problems of large side effects, poor broad-spectrum antibacterial properties, etc., and achieve the effects of low cytotoxicity, accelerated healing, and good softness

Active Publication Date: 2022-07-08
SHENZHEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a bacterial cellulose-based photosensitive antibacterial dressin

Method used

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  • Bacterial cellulose-based photosensitive antibacterial dressing as well as preparation method and application thereof
  • Bacterial cellulose-based photosensitive antibacterial dressing as well as preparation method and application thereof
  • Bacterial cellulose-based photosensitive antibacterial dressing as well as preparation method and application thereof

Examples

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Example Embodiment

[0050] Example 1

[0051] The preparation method of bacterial cellulose-based photosensitive antibacterial dressing specifically includes the following steps:

[0052] (1) The bacterial cellulose membranes with different pore sizes were rinsed with ultrapure water for several times to remove the bacterial culture medium and Acetobacter xylinum remaining on the surface, and then soaked in ultrapure water for 3 days, during which the water was changed every 12h.

[0053] (2) Prepare an aqueous sodium hydroxide solution with a mass fraction of 1%, add the bacterial cellulose membrane in step (1) to the prepared alkaline solution, put it in a pot and boil for 30 minutes, rinse with ultrapure water for many times, remove Sodium hydroxide in water, and finally high temperature, high pressure sterilization and soaking in ultrapure water to obtain bacterial cellulose for later use, such as figure 1 shown.

[0054] (3) Prepare 1 mL each of BITT molecular solutions with concentrations...

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Abstract

The invention discloses a bacterial cellulose-based photosensitive antibacterial dressing and a preparation method and application thereof, and the method comprises the following steps: providing bacterial cellulose; photosensitizer BITT molecular solutions with different concentrations are prepared, the chemical structural formula of BITT molecules is shown in the specification, the bacterial cellulose is dried and then soaked in the photosensitizer BITT molecular solutions, and the bacterial cellulose based photosensitive antibacterial dressing is obtained. The bacterial cellulose-based photosensitive antibacterial dressing provided by the invention has a very good bactericidal effect (the bactericidal rate is gt; the photodynamic and photo-thermal synergistic sterilization mode does not cause the drug resistance of bacteria, and the mild photo-thermal effect can promote the proliferation of cells and the regeneration of blood vessels and accelerate the healing of wounds; the prepared composite dressing has good transparency, and the healing degree of a wound can be observed in real time; the dressing is good in softness, has wearable performance and can be tightly attached to wounds of different parts; and the dressing is biodegradable, green and environment-friendly.

Description

technical field [0001] The invention relates to the technical field of biomedical nanomaterials, in particular to a bacterial cellulose-based photosensitive antibacterial dressing and a preparation method and application thereof. Background technique [0002] As the main component of plant cell walls, cellulose is the most abundant natural polymer in nature. In addition to plants, some specific bacteria such as Acetobacter xylinum, Rhizobium, Agrobacterium, Pseudomonas and Salmonella can also produce cellulose, which is called bacterial cellulose. Compared with plant cellulose, bacterial cellulose has the advantages of high purity, high porosity, ultra-fine nano-network structure, high water absorption capacity and high mechanical strength. In addition, studies have found that bacterial cellulose has good biocompatibility in vivo and in vitro, and is a biodegradable material, which is widely used in food, biomedical and other fields. [0003] As a wound dressing, bacterial...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/20A61L15/42A61L15/46A61L15/62A61K41/00A61P31/04A61P17/02C12P19/04C12R1/01
CPCA61L15/28A61L15/20A61L15/42A61L15/46A61L15/62A61K41/0057A61K41/0052A61P31/04A61P17/02C12P19/04A61L2300/404A61L2300/412A61L2300/232C08L1/02Y02A50/30
Inventor 李莹沈紫鹏杨光王东
Owner SHENZHEN UNIV
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