High-strength hydroxyapatite-bamboo-based bioactive scaffold and preparation method thereof
A hydroxyapatite and biologically active technology, applied in medical science, prosthesis, coating, etc., can solve problems such as difficult to provide bone regeneration at the same time, and achieve the goal of maintaining multi-level pore structure, maintaining mechanical strength, and easy control of conditions Effect
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Embodiment 1
[0056] a) To a mass fraction of 10% NaClO 2 The delignification solution is prepared by adding 0.1% Triton X-100 to the solution, wherein the mass ratio of sodium chlorite solution to Triton X-100 is 100:1;
[0057] b) immersing the natural bamboo scaffold from which the epidermis has been removed at room temperature for 30 days into the delignification solution, until the lignin therein is completely removed and taken out;
[0058] c) repeatedly ultrasonically washing the sample until the solution is clarified, and naturally drying to obtain a delignified bamboo-based template;
[0059] d) after immersing the bamboo-based template in the calcium chloride solution of 100 mg / mL for 24 hours, take out and dry naturally at normal temperature;
[0060] e) The scaffolds were further mineralized in a simulated body fluid solution at 37°C for 1 day.
[0061] The surface of the cell wall of the scaffold after mineralization was covered with nano-hydroxyapatite particles; the Ca / P ra...
Embodiment 2
[0063] a) To a mass fraction of 10% NaClO 2 The delignification solution is prepared by adding 0.1% Triton X-100 to the solution, wherein the mass ratio of sodium chlorite solution to Triton X-100 is 100:1;
[0064] b) immersing the natural bamboo scaffold from which the epidermis has been removed at room temperature for 30 days into the delignification solution, until the lignin therein is completely removed and taken out;
[0065] c) repeatedly ultrasonically washing the sample until the solution is clarified, and naturally drying to obtain a delignified bamboo-based template;
[0066] d) After immersing the bamboo-based template in the calcium chloride solution of 100 mg / mL for 24 hours, take it out to dry;
[0067] e) The scaffold was further immersed in a simulated body fluid solution and placed in a 37°C environment for mineralization for 3 days, and the simulated body fluid solution was replaced every day during the mineralization process.
[0068] The surface of the ...
Embodiment 3
[0070] a) To a mass fraction of 10% NaClO 2 The delignification solution is prepared by adding 0.1% Triton X-100 to the solution, wherein the mass ratio of sodium chlorite solution to Triton X-100 is 100:1;
[0071]b) immersing the natural bamboo scaffold from which the epidermis has been removed at room temperature for 30 days into the delignification solution, until the lignin therein is completely removed and taken out;
[0072] c) repeatedly ultrasonically washing the sample until the solution is clarified, and naturally drying to obtain a delignified bamboo-based template;
[0073] d) After immersing the bamboo-based template in the calcium chloride solution of 100 mg / mL for 24 hours, take it out to dry;
[0074] e) The scaffold was further immersed in a simulated body fluid solution and placed in a 37°C environment for 7 days for mineralization. During the mineralization process, the simulated body fluid solution was replaced every day.
[0075] The surface of the cell...
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