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Cyanoacrylate medical adhesive as well as preparation method and application thereof

A technology of cyanoacrylate and cyanoacrylic acid, which is applied in the fields of application, medical science, surgery, etc., can solve the problems affecting the closure rate, deglue phenomenon, easy generation of debris, etc., and achieve the improvement of tensile strength and closure strength, Excellent bonding performance, the effect of improving comfort

Inactive Publication Date: 2022-07-29
BEIJING COMPONT MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] my country's medical glue started earlier, but currently there is no medical glue that can be completely used for varicose veins in the market. The main problems in clinical practice are: 1) The polymerization speed is too fast, and it cannot be used in conjunction with existing catheters. 2) The glue block formed in the blood vessel is hard, has poor flexibility resistance, and is easy to break and generate debris. On the one hand, as a foreign body, it is easy to cause discomfort or even inflammation
On the other hand, the generated debris may form ectopic embolism with the flow of blood; 3) The generated rubber block is relatively hard, which is easy to cause foreign body rejection, so that the phenomenon of gel discharge occurs, which brings discomfort to the patient on the one hand , on the other hand can also affect the closure rate

Method used

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  • Cyanoacrylate medical adhesive as well as preparation method and application thereof
  • Cyanoacrylate medical adhesive as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0063] 1) Preparation of samples to be tested:

[0064] Select the pig skin on both sides of the pig's abdomen, remove the fat layer on the surface until the dermis is exposed, wash and dry, and cut into a rectangle. The length is greater than 5 cm, the width is 2.5 ± 0.1 cm, and the thickness is less than 5 mm.

[0065] 2) Bonding performance test: Use medical glue to bond two pieces of pig skins together, and test the bonding performance indicators of the gel hemostatic material according to the testing method in YY / T 0729-2009.

[0066] 4. Rockwell hardness test

[0067] Take a 20 cm EVA tube with a diameter of 1 cm, and after injecting sheep blood, close one end and flatten it to a sheet with a thickness of about 2 mm. Use a 4 Fr PTFE tube to inject medical glue into the EVA tube. At the same time, withdraw the PTFE tube until 2 mL of medical glue is completely injected into the EVA tube. After complete polymerization, use a scalpel to cut off the tube, rinse with purif...

preparation example 1

[0074] Preparation Example 1: Preparation of n-butyl cyanoacrylate

[0075] Add n-butyl cyanoacetate (200 g, 1.42 mol, Tixiai (Shanghai) Chemical Industry Development Co., Ltd.), 1,2-dichloroethane (100 ml, Sinopharm Chemical Reagent Co., Ltd.) to 1 L of In a four-necked flask, heated to between 65-70 ℃, add dropwise aqueous formaldehyde solution (36%, 109 g, 1.31 mol, Sinopharm Chemical Reagent Co., Ltd.), piperidine (1 mL, Sinopharm Chemical Reagent Co., Ltd.) During the dropwise addition, the reaction temperature was controlled not to exceed 80°C. After the dropwise addition, heat to reflux, and continue to stir for 3 hours, stop heating, add 10 mL of phosphoric acid, and stir for 10 min, install a water separation device to separate water, until no obvious water droplets can be seen in the system, change the separation. The water device is a distillation device to remove the residual solvent in the system, and add dibutyl phthalate (80mL, Sinopharm Chemical Reagent Co.,...

preparation example 2

[0077] Preparation Example 2: Preparation of sec-octyl cyanoacrylate

[0078] According to the method similar to Preparation Example 1, prepare sec-octyl cyanoacrylate, feed intake and yield are as follows: sec-octyl cyanoacetate (200 g, 1.01 mol, Tixiai (Shanghai) Chemical Industry Development Co., Ltd.), 1 ,2-dichloroethane (200ml, Sinopharm Chemical Reagent Co., Ltd.), aqueous formaldehyde solution (36%, 78 g, 0.94 mol, Sinopharm Group Chemical Reagent Co., Ltd.), piperidine (1 mL, Sinopharm Group Chemical Reagent Co., Ltd.) ). Dibutyl phthalate (80 mL, Sinopharm Group Chemical Reagent Co., Ltd.), hydroquinone (4 g, Sinopharm Group Chemical Reagent Co., Ltd.), p-toluenesulfonic acid (2 g, Sinopharm Group Chemical Reagent Co., Ltd.) , phosphorus pentoxide (4 g, Sinopharm Chemical Reagent Co., Ltd.) to obtain pure sec-octyl cyanoacrylate (102 g, 0.49 mol, yield 48.5%).

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Abstract

The invention relates to a cyanoacrylate medical adhesive as well as a preparation method and application thereof. The cyanoacrylate medical adhesive is prepared from a cyanoacrylate compound, a comonomer and a thickening agent. When the cyanoacrylate medical adhesive disclosed by the invention is applied to vascular embolism, the cyanoacrylate medical adhesive has proper polymerization time, a cured product has excellent flexibility and proper hardness, and meanwhile, the cyanoacrylate medical adhesive has excellent adhesive property and very good clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a cyanoacrylate medical glue and a preparation method and application thereof. The cyanoacrylate medical glue of the present invention has suitable polymerization speed, good toughness, and is not easy to generate slag. Background technique [0002] Currently commercially available cyanoacrylate compounds can be represented by the chemical structural formula of the following formula I: [0003] , [0004] Wherein, R can be linear, branched or cyclic alkyl with 1-20 carbon atoms, etc.; [0005] Alternatively, R can also be of formula -R 2 -O-R 3 groups where R 2 and R 3 each independently a linear, branched or cyclic alkyl group having 1 to 20 carbon atoms; [0006] Alternatively, R can be of the formula -R 4 -COO-R 5 groups where R 4 and R 5 Each independently is a linear, branched or cyclic alkyl group having 1 to 20 carbon atoms. [0007] The cyanoacr...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/00
CPCA61L24/06A61L24/001C08L33/14
Inventor 沈箫沈伟徐景海田明月
Owner BEIJING COMPONT MEDICAL DEVICES
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