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Anti-depression sleep-aiding autolytic microneedle patch and preparation method thereof

A self-dissolving microneedle and anti-depressant technology, which is applied in the field of medical devices, can solve problems such as easy disintegration and adverse drug reactions, and achieve the effects of improving sleep quality, increasing sleep duration, and shortening the duration of falling asleep

Pending Publication Date: 2022-08-02
CHINA NAT INST OF STANDARDIZATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current commonly used form is made into tablets or drops for oral administration, but water-soluble CBD microcapsules are easily disintegrated after being corroded by gastric acid, and the CBD inside is not easily absorbed by the intestinal tract, which affects the efficacy of the drug. The way of intestinal absorption is also prone to adverse drug reactions that cause gastrointestinal discomfort

Method used

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  • Anti-depression sleep-aiding autolytic microneedle patch and preparation method thereof
  • Anti-depression sleep-aiding autolytic microneedle patch and preparation method thereof
  • Anti-depression sleep-aiding autolytic microneedle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation method of water-soluble CBD microcapsules

[0037] 1) Accurately weigh 100g of CBD crystal powder with a purity higher than 99% in 300ml of ethanol aqueous solution, heat at 60°C and stir for 10-30 minutes until completely dissolved, then cool to room temperature for later use.

[0038] 2) Weigh 200g of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, and hydroxypropyl-β-cyclodextrin, respectively, add 1000g of first-grade purified water, and stir with or without heating until completely dissolved , and then add the CBD solution dissolved in step (1), and continue to stir with or without heating.

[0039] 3) Put the mixed solution prepared in step (2) into an airtight container, ultrasonically treat it with an ultrasonic generator for 1-4 hours, ultrasonic power 5000-8000W, temperature 20-60 ° C; after ultrasonic treatment, use a rotary evaporator to decompress Concentrate to remove most of the solvent and moisture. Transfer the processed ...

Embodiment 2

[0045] Embodiment 2: the preparation method of antidepressant microneedle

[0046] The water-soluble CBD micro-scale capsules prepared in Example 3 are mixed with sodium hyaluronate, polyvinylpyrrolidone and water, and the ratio is water-soluble CBD: sodium hyaluronate: polyvinylpyrrolidone: water=0.4:2.5:1.5: 12. All polymer solutions were centrifuged at 5000 rpm for 5 minutes to remove air bubbles. Each micro mold consists of 100 (10*10) conical (cone, triangular cone) needles, the polymer solution is introduced into the mold, and then in a vacuum environment, pressure (0.1MPa) is applied for about 10 minutes to promote polymerization The microneedle mold was centrifuged at 4500 rpm for 30 minutes to remove trapped air bubbles and the polymer solution was filled into the microneedle tips. Next, the molds were dried at 25°C for 48 hours. Finally, the microneedles are removed after drying.

Embodiment 3

[0047] Example 3: Microneedle Performance Test

[0048] 1) Needle content: observed under a microscope, it is good if it reaches 100%, good if it reaches 80%, and poor if it is less than 80%.

[0049] 2) Mechanical properties: The evaluation standard is that it can pass through the aluminum foil paper as good, and can not pass through the aluminum foil paper as poor.

[0050] 3) Hygroscopicity: The evaluation standard is that the hygroscopicity of microneedles that can pass through more than 2 layers of aluminum foil paper smoothly after being placed in a high-humidity environment for 12 hours is good, and the hygroscopicity of microneedles that can only pass through 1 layer of aluminum foil paper is medium, and cannot be The hygroscopicity of the microneedles passing through the aluminum foil was poor.

[0051] 4) Release: Franz transdermal diffusion cell was used to evaluate the in vitro release performance of the prepared CBD self-dissolving microneedle patch. Fix the CBD...

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Abstract

The invention belongs to the technical field of medical instruments, and particularly relates to an anti-depression sleep-aiding autolytic microneedle patch and a preparation method thereof. The autolytic microneedle patch is composed of a water-soluble cannabidiol microcapsule and a microneedle matrix material, the particle size of the water-soluble cannabidiol microcapsule is 200-500 [mu] m, and the water-soluble cannabidiol microcapsule is formed by wrapping cannabidiol with alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin or hydroxypropyl-beta-cyclodextrin. The prepared microneedle patch can quickly take effect on the human body, the medicine starts to be dissolved out and permeate into the human body from 37 min, and the medicine effect can be kept for 100 min or above. Therefore, the sleep quality of the depression patient can be quickly improved, including obviously shortening the sleep time and prolonging the continuous sleep time.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an antidepressant and sleep-aiding autolytic microneedle patch and a preparation method. Background technique [0002] Depressive disorder, also known as depression, is characterized by obvious and long-term low mood. In recent years, the research and development of antidepressants has become one of the hot research fields in psychiatry. Currently commonly used clinical antidepressants include tricyclic antidepressants (TCAs), norepinephrine reuptake inhibitors (NARIs), monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs) and Dopamine (DA) reuptake inhibitors, etc. Among them, SSRIs have become the first-line treatment for depression, but they take a long period of time and may cause unbearable adverse drug reactions, including sexual dysfunction, weight gain, nausea and headache. [0003] Most patients with depression are o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K9/00A61K9/50A61K31/05A61K47/32A61K47/36A61K47/40A61P25/20A61P25/24
CPCA61M37/0015A61K9/0021A61K9/5036A61K31/05A61K47/36A61K47/32A61P25/24A61P25/20A61M2037/0046A61M2037/0053
Inventor 兰韬云振宇吴琦
Owner CHINA NAT INST OF STANDARDIZATION
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