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Preparation and application of cardiac muscle repair stent

A kind of myocardial and biofilm technology, applied in the direction of catheter, can solve the problem of unable to repair myocardial tissue, and achieve the effect of improving cardiac blood supply function, significant therapeutic effect and wide application prospect.

Active Publication Date: 2006-04-12
于海鹰
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

As we all know, the damage to myocardial tissue in heart disease can only be improved by placing solid stents in blood vessels to expand arteries or performing arterial branch bypass surgery to improve blood supply to damaged parts of the heart. Although heart function can be partially improved, damage cannot Myocardial tissue has been repaired, and now because of the new bio-collagen material, it is possible to repair damaged myocardial tissue by using bio-collagen material, how to use bio-collagen material to prepare myocardial repair scaffold and use it to repair damaged Myocardial tissue is the problem that the present invention needs to solve

Method used

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Embodiment Construction

[0008] Describe the present invention in detail below in conjunction with embodiment:

[0009] A method for preparing a scaffold for myocardial repair, the preparation steps are as follows: use animal connective tissue as a base material, treat with acid and alkali, add protease and chondroitin sulfate to cross-link, dry and sterilize, and make a spongy shape with a thickness of 1.2 mm Rectangular solid medical collagen biofilm is ready for use. The spongy inter-pores formed in the biofilm are 80 microns, and then the autologous bone marrow stem cells of pigs from sick experimental animals are extracted. The amount of extraction is 3 million units, and the extracted bone marrow stem cells are Routine culture in a standard incubator for 10 days, the cultured bone marrow stem cells were implanted into square collagen biofilm under aseptic conditions 5 hours before use to form a biological scaffold for myocardial repair, after 5 hours of adaptation and culture, surgery The rectan...

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Abstract

The invention discloses a cardiac muscle repairing stent preparation process and its application. It makes the animal connective tissue as basic material and goes through the process of acid and alkali treatment, protease and sulfuric acid cartilage cross linkage, drying sterilization to make spongilid solid collagen protein biological membrane for use. Extracting patients autogenous bone marrow stem cell, culturing 4 to 15 days in standard temperature box. implanting the cultured bone marrow stem cell to collagen protein biological membrane ahead of the operation for 4 to 6 hours to build biological cardiac muscle repairing stent. It is used by pasting to cardiac muscle tissue directly for patients in practice.

Description

Technical field: [0001] The invention relates to the technical field of biomaterials for medical trauma, in particular to the preparation and application of a myocardial repair bracket. Background technique: [0002] With the advancement of medical science and technology and the continuous development of medical materials, the research and clinical application of collagen-based products in the medical field are on the rise in recent years, especially medical products made of collagen materials in the form of films or sponges Obtained remarkable development, as Chinese patent patent number is 021212779, and patent title is medical collagen protein material and its manufacturing process and just discloses a kind of medical collagen protein material, is base material by animal connective tissue through impurity removal, cleaning, acid, Alkali treatment, protease enzymatic hydrolysis, chondroitin sulfate cross-linking, low-temperature dehydration forming, drying and ethylene oxi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/00
Inventor 于海鹰
Owner 于海鹰
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