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Sodium alginate microglobule blood vessel suppositery containing gynecoiatry medicine and its preparation method

A vascular embolic agent, sodium alginate technology, applied in the field of sodium alginate microsphere vascular embolic agent and its preparation, can solve the problems of relatively uniform sustained release of drugs, damage, tissue necrosis, etc., and achieve good biocompatibility , improve curative effect, reduce toxic and side effects

Active Publication Date: 2007-05-02
BEIJING SHENGYIYAO SCI & TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] The disadvantages of local drug perfusion embolization are: first, the drug cannot be released relatively uniformly and continuously; second, when the local perfusion drug concentration is too high, the shock wave effect of the drug may cause local tissue necrosis or damage
[0021] At present, there is no precedent at home and abroad where sodium alginate is used as a drug carrier to wrap gynecological drugs and apply them to interventional embolization of gynecological diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of Sodium Alginate Microspheres Containing Danazol

[0048] 1. Preparations before packing:

[0049] ① Handling of glassware:

[0050] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0051] ②Preparation of gynecological drug Danazol liquid:

[0052] Take by weighing 1.5 kilograms of commercially available danazol, place in the above-mentioned glass vessel, add dropwise propylene glycol until all dissolve; get danazol drug solution;

[0053] ③ Preparation of sodium alginate solution:

[0054] Weigh 2 kg of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0055] ④ Prepare 1% calcium chloride solution;

[0056] ⑤ mixing the above-mentioned danazol solution with the sodium alginate solution to obtain a sodium alginate mixed soluti...

Embodiment 2

[0062] Preparation of Sodium Alginate Microspheres Containing Gonadotropin-releasing Hormone Analogs

[0063] 1. Preparations before packing:

[0064] ① Handling of glassware:

[0065] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0066] ② Preparation of gonadotropin-releasing hormone analog liquid for gynecological medicine:

[0067] Take by weighing 2 kilograms of commercially available gonadotropin-releasing hormone analogues, place in the above-mentioned glass vessel, add physiological saline dropwise, until all dissolve; obtain gonadotropin-releasing hormone analogue drug solution;

[0068] ③ Preparation of sodium alginate solution:

[0069] Weigh 20 kg of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0070] ④ Prepare 10% magnesium chlo...

Embodiment 3

[0077] Preparation of Sodium Alginate Microspheres Containing Androgen

[0078] 1. Preparations before packing:

[0079] ① Handling of glassware:

[0080] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0081] ②Preparation of androgen medicinal liquid for gynecological medicine:

[0082] Weigh 2 kg of commercially available androgen, place it in the above-mentioned glass vessel, add acetone dropwise until all dissolve; obtain androgen drug solution;

[0083] ③ Preparation of sodium alginate solution:

[0084] Weigh 50 kg of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0085] ④ prepare 6% magnesium chloride solution;

[0086] ⑤ mixing the above-mentioned androgen solution with the sodium alginate solution to obtain a sodium alginate mixed sol...

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Abstract

A sodium alginate microsphere containing gynecologic medicine used as vascular plocking agent for treating hysteromyoma, endometrioma, etc is prepared through preparing the solution of gynecologic medicine, the solution of sodium alginate and the solution of barium (or magnesium) chloride, and sequentially mixing.

Description

technical field [0001] The invention relates to a sodium alginate microsphere vascular embolization agent containing gynecological drugs and a preparation method thereof. Background technique [0002] Both uterine fibroids and adenomyosis are the most common benign diseases of the female reproductive system. Because of their high incidence, they seriously affect the quality of life of women. Current treatment methods mainly include drugs and surgery. Surgical treatment is mainly total hysterectomy, which is suitable for those with severe symptoms, older age and no fertility requirements. For young people who want to have children or who are near menopause and those with mild symptoms, drug treatment can be tried, such as danazol, gonadotropin-releasing hormone analog (GnRHa), mifepristone (Ru486), androgen, gestrinone, etc. . [0003] Danazol is a synthetic 17-ethynyl testosterone derivative, which has a weak androgenic effect. In vitro experiments have confirmed that dan...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K31/56A61K38/22A61L17/00A61B17/12A61M31/00A61P15/00
Inventor 徐丛剑李新建郎景和向阳雷呈志洪宏鲁格康玉包怡榕
Owner BEIJING SHENGYIYAO SCI & TECH DEV
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