Process for preparing high purity acarbose

A high-purity acarbose technology, which is applied in the field of preparing high-purity acarbose by membrane technology, can solve the problems affecting the quality of acarbose products, affecting the overall yield of resin extraction process, and long production process routes.

Active Publication Date: 2007-06-13
SANDA FILM SCI & TECH XIAMEN
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  • Summary
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  • Claims
  • Application Information

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Problems solved by technology

However, the production process route is long, and the loss of acarbose in each step is still relatively high, resulting in an unsatisfactory total yield of the final acarbose product. Moreover, the primary membrane system separates and collects to obtain acarbose The salt content in the filtrate will still increase the load of the subsequent resin extraction process, and affect the overall yield of the resin extraction process, and also affect the quality of the final acarbose product

Method used

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  • Process for preparing high purity acarbose
  • Process for preparing high purity acarbose

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Firstly, the acarbose fermentation broth is filtered with an organic flat ultrafiltration membrane with a molecular weight cut-off of 50,000, the average membrane flux can reach 58LMH, the amount of water added is 1.5 times the amount of the raw material solution, and the final concentration ratio is 2.0 times. The average yield of ultrafiltration membrane filtration is 99%, far higher than the average yield of 80% of the original plate frame; through the filtration of large molecular weight ultrafiltration system, mycelia and most of the macromolecular proteins (such as soluble protein, culture Base and some pigments, etc.), the filtrate has high clarity and good quality, which can meet the production process requirements.

[0029] Then it is further concentrated by nanofiltration membrane, and desalted and decolorized. The system uses roll-type nanofiltration membrane with a molecular weight cut-off of 200. The average membrane flux is 25LMH. The amount of water added ...

Embodiment 2

[0033] Firstly, the acarbose fermentation broth is filtered with an organic flat ultrafiltration membrane with a molecular weight cut-off of 30,000. The average membrane flux can reach 50LMH. The amount of water added is 2.5 times that of the raw material liquid, and the final concentration is 3 times. The average yield of ultrafiltration membrane filtration is 99%, far higher than the average yield of 80% of the original plate frame; through the filtration of large molecular weight ultrafiltration system, mycelia and most of the macromolecular proteins (such as soluble protein, culture Base and some pigments, etc.), the filtrate has high clarity and good quality, which can meet the production process requirements.

[0034] Then it is further concentrated by nanofiltration membrane, and desalted and decolorized. The system uses roll-type nanofiltration membrane with a molecular weight cut-off of 300. The average membrane flux is 32LMH. The amount of water added can be controlle...

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Abstract

The present invention discloses the preparation process of high purity acarbose. The fermented liquid with acarbose is first separated in the first separation system to eliminate mycelium, soluble protein, culture medium and partial pigment to obtain clear acarbose filtrate; the clear acarbose filtrate is then concentrated, decolorized and desalted to eliminate partial monosaccharide, inorganic salt and other small molecular impurity to obtain clear acarbose concentrated solution; and finally through chromatographic resin adsorption, gradient acid pickling, nano filtering film concentration and spray drying, high purity acarbose product is obtained. The present invention has shortened technological path, high total acarbose yield and high product purity.

Description

technical field [0001] The invention relates to a method for preparing acarbose, in particular to a method for preparing high-purity acarbose by membrane technology. Background technique [0002] Acarbose, whose trade name is Baisupine or Inhibitory α-glucosidase, is white or off-white powder, odorless and tasteless; its chemical name is 0-4,6-dideoxy-4-[(1S, 4R, 5S, 6S)-4,5,6-trihydroxy-3-hydroxymethyl-2-cyclohexenyl-1-amino]-a-D-glucopyranosyl-(1→4)-O-a-D-pyridine Glucopyranosyl-(1→4)-D glucopyranose; molecular formula is C25H43NO18; molecular weight is 645.63. [0003] Acarbose is a new type of oral hypoglycemic drug that competitively inhibits α-glucosidase in the intestinal tract, can reduce the decomposition of polysaccharides and sucrose to generate glucose, and reduce and delay absorption. Therefore, it has the effect of reducing postprandial hyperglycemia and plasma insulin concentration. effect. [0004] At present, acarbose is produced by fermentation, and the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H5/06C07H1/06
Inventor 蒋林煜林凌涛
Owner SANDA FILM SCI & TECH XIAMEN
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