Preparation process of radioactive istope gallium-67

Abstract

The preparation process of radioisotope gallium-67 relates to a separation and purification process of radioisotope gallium-67 produced by cyclotron. It is characterized by including the following steps: adding oxidant which does not affect the separation process and H2O2 solution into the concentrated hydrochloric acid in which the zinc target bombarded by proton beam is dissolved so as to make low-valence gallium-67 (67Ga1+, 67Ga2+) ions in the target dissolving solution oxidate into trivalence ions (67Ga3+), then evaporating and drying, adding hydrochloric solution of SnCl2 to make furthersolvation, reducing impurity iron ion (Fe3+) and using cation-exchanginging column to separate and purifying Ga-67. Said invention adopts the addition of two reagents of H2O2 and SnCl2, obtains high recovery rate (95%) of Ga-67 and high quality (impurity iron content is less than 5 microgram / ml-5mCi-Ga-67). It can ensure that the impurity iron content in the tumor imaging agent gallium citrate made up by using said invention is as low as possible.

Description

1. Technical field [0001] The invention belongs to the technical field of radioisotope preparation, in particular to a process for separating and purifying gallium-67 radioisotope produced by bombarding a zinc-68 target with protons accelerated by a cyclotron. 2. Background technology [0002] 67 Ga is an important nuclide in nuclear medicine. Gallium citrate prepared from it can concentrate in many cancerous tumor tissues. Diagnosis and identification are of great significance. Therefore, this radioisotope has been researched and applied in the field of nuclear medicine as early as the 1970s. [0003] There are many chemical separation methods for gallium-67, mainly divided into organic solvent extraction and ion exchange. There are also many organic solvents used to extract gallium-67 radioactive isotope. The main disadvantage of this method is that the radioactive organic solution produced is not easy to handle, and it is not good for the organic solvent to enter the hu...

AI Technical Summary

Problems solved by technology

Reduced Fe used in the literature 3+ There are three main reducing agents, namely TiCl 3 , KI or NaI and ascorbic acid (Vc), but practice has proved that the results are not ideal; use TiCl 3 As reducing agent method, Ti 3+ In reducing Fe 3+ become Ti 4+ , this kind of ion is easily hydrolyzed into hydrated titanium oxide precipitation at low acid, and forms a thin layer of shell on the outer surface of the resin, which makes the resin lose its ion exchange capacity, that is, "resin poisoning", affecting 67 The product quality and the yield of Ga, the effect that resin regeneration is used is bad simultaneously; When using KI or NaI reducing agent, due to iodide ion (I - ) standard potential (0.536V) and ferrous ions (Fe 2+ ) standard potential (0.771V) is closer, so the reduction of ferric ions (Fe 3+ ) is slow, and the effect is poor. At the same time, iodine molecules (I 2 ), it is not easy to remove in the product, which affects the chroma of the product; as for the use of ascorbic acid (VC), it is not easy to separate due to its instability and low solubility