Surface-treatment of silicone medical devices comprising intermediate carbon coating and graft polymerization
A medical device, siloxane technology, applied in the field of medical devices, can solve problems such as too deep grafting depth, insufficient grafting density, and improved properties
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Embodiment 1
[0100] This example discloses a typical silicone hydrogel lens material used in the following examples. Table 1 below provides the formulation of polysiloxane fumarate hydrogel compositions for use in the manufacture of lens matrices to be subsequently surface modified in accordance with the present invention:
[0101] components
parts by weight
f 2 D. 20
20
40
DMA
50
n-Hexanol
5
DAROCUR-1173
0.5
IMVT
150ppm
[0102] TRIS: Tris(trimethylsiloxy)silylpropyl methacrylate
[0103] DMA: N,N-Dimethacrylamide
[0104] f 2 D. 20 : a siloxane-containing cross-linked resin, such as the previous U.S. Patent 5,374,662 and
[0105] 5,496,871 described.
[0106] Darocur: a UV initiator
[0107] IMVT: A toner that is 1,4-bis[4-(2-methacryloyloxyethyl)phenylamino
[0108] Anthraquinone
Embodiment 2
[0110] This example illustrates a typical method for preparing contact lenses prior to surface modification according to the invention. Silicone hydrogel lenses made from the composition of Example 1 above were released from polypropylene molds. Under an inert nitrogen atmosphere, 45 μl of the composition was injected onto a clean polypropylene female mold half and covered with a complementary polypropylene male mold half. The two mold halves are compressed under 70 psi (pounds per square inch) pressure, and the mixture is then subjected to UV light (6-11 mW / cm 2 , measured by a UV spectrometer) was cured for about 15 minutes, and the mold continued to be exposed to a UV lamp for about 5 minutes. The upper mold half was removed and the lenses were then placed in a forced air oven at 60°C for three hours to remove the n-hexanol. Subsequently, the edge of the lens was ball milled for 10 seconds at 2300 rpm with 60 grams of force.
Embodiment 3
[0112] This example illustrates the surface modification of contact lenses in accordance with the present invention. Lenses were made from the composition of Example 1 (silicone fumarate, 36% water after hydration). Before the plasma treatment of the lens, the plasma chamber is first evacuated to 0.01 Torr to extract the residual gas in the chamber. Surface modification included an initial oxidizing plasma treatment at 1.0 Torr, 200 Watts for 5 minutes in an air / water / peroxide atmosphere. This was followed by a hydrocarbon coating (using methane or butadiene) deposition at 150 watts, 0.5 Torr for 5 minutes on each side. After the carbonaceous surface layer is covered, the surface is hydrophilized by an electric surface treatment method using a manually controlled TANTEC LAB SYSTEM corona discharge system. The samples were corona-discharge treated in air at atmospheric pressure. This method uses a maximum volume of 250 watts or a maximum electrode voltage of 20,000 volts (pe...
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Abstract
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