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Production of water soluble, less water soluble or water non soluble active compound solid product

A water-insoluble and water-soluble technology, applied in cosmetic preparations, active ingredients of hydrocarbon compounds, active ingredients of hydroxyl compounds, etc., can solve microbial contamination, insufficient bioavailability of stable astaxanthin, and chemical incompatibility. stability issues

Inactive Publication Date: 2002-08-21
BASF AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of these suspensions and the bioavailability of astaxanthin present therein are sometimes insufficient for many applications
[0013] Carotenoid emulsions, as a specific form of liquid formulations, often have the following disadvantages: they are physically (phase separation occurs) and chemical (unwanted hydrolysis and / or redox reactions occur, chemical incompatibility of the separately dissolved components sex) is unstable, in addition, there is a constant risk of microbial contamination
[0015] In the presence of a stable protective colloid, this preparation and the numerous described aqueous carotenoid dispersions and O / W emulsions containing the active compound are also unsuitable due to their immiscibility with oils

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0219] Astaxanthin dry powder

[0220] 45 g of crystalline astaxanthin were suspended in 375 g of an azeotropic isopropanol / water mixture at room temperature. The active compound suspension was then heated to 96°C and mixed continuously at a flow rate of 2.1 kg / h with an additional isopropanol / water azeotrope at a temperature of 227°C and a flow rate of 2.7 kg / h. The cyanine dissolves at a mixing temperature of 169°C and a pressure of 60 bar. The resulting active compound solution was then mixed at a flow rate of 56.1 kg / h with an aqueous phase solution of 80 g of sodium caseinate in 12 L of distilled water, the pH of which was adjusted to 8.0 using 18 mL of 1 M NaOH.

[0221] The nanoparticulate active compound particles formed during mixing had a fineness of 100 nm in the isopropanol / water mixture. The active compound dispersion is then adjusted to pH 4.8 using 1M HCl, causing the active compound / caseinate particles to flocculate out. The flocculated particles were filter...

Embodiment 2

[0223] Astaxanthin dry powder

[0224] 50 g of crystalline astaxanthin and 5.6 g of ethoxyquin were suspended in 416 g of an azeotropic isopropanol / water mixture at room temperature. The active compound suspension was then heated to 97°C and mixed continuously at a flow rate of 2.1 kg / h with an additional isopropanol / water azeotrope at a temperature of 216°C and a flow rate of 2.7 kg / h. The cyanine dissolves at a mixing temperature of 169°C and a pressure of 60 bar. The resulting active compound solution was then mixed with the following aqueous phase solution at a flow rate of 55.6 kg / h: 23.3 g of sodium caseinate in 14 L of distilled water, the pH of which was adjusted to 8.3 using 5 mL of 1 M NaOH.

[0225] The fineness of the active compound particles formed during mixing in the isopropanol / water mixture was 116 nm. The active compound dispersion is then adjusted to pH 4.8 using 1M HCl, causing the active compound / caseinate particles to flocculate out. The suspension wa...

Embodiment 3

[0227] Dry Lycopene Powder

[0228] 45 g of crystalline lycopene, 3.6 g of palmitic acid and 6.6 g of tocopherol were suspended in 388 g of an azeotropic isopropanol / water mixture at room temperature. The active compound suspension was then heated to 94°C and mixed at a flow rate of 2.0 kg / h with a further isopropanol / water azeotrope at a temperature of 206°C and a flow rate of 3.3 kg / h, lycopene The element dissolves at a mixing temperature of 171 °C and a pressure of 63 bar. The resulting active compound solution was then mixed with the following aqueous phase solution at a flow rate of 33.8 kg / h: 80 g of sodium caseinate in 7 L of distilled water, the pH of which was adjusted to 8.0 using 19 mL of 1 M NaOH.

[0229] The fineness of the active compound particles formed during the mixing in the isopropanol / water mixture was 125 nm. The active compound dispersion is then adjusted to pH 4.8 using 1M HCl, causing the active compound / caseinate particles to flocculate out. The ...

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Abstract

A process is described for producing solid preparations of at least one water-soluble, sparingly water-soluble or water-insoluble active compound suitable for the food and animal feed sectors or for pharmaceutical and cosmetic applications. In addition, the invention relates to oily suspensions in which these preparations are present as disperse phase, and to the use of these preparations as additive to animal feeds, foods, pharmaceuticals and cosmetic preparations.

Description

technical field [0001] The invention relates to a process for the production of solid preparations of at least one water-soluble, sparingly water-soluble or water-insoluble active compound suitable for use as food and animal feed ingredients or for pharmaceuticals and cosmetics. Furthermore the invention relates to oily suspensions containing these preparations and their use as additives for animal feed, food, pharmaceuticals and cosmetics. Background technique [0002] A large number of active compounds suitable for use in food and animal feed ingredients or in pharmaceuticals and cosmetics, such as fat-soluble vitamins, carotenoids, and the natural pigments curcumin and carmine, can only be used due to their water insolubility and sensitivity to oxidation. It is used in the form of particularly stable preparations. These crystalline materials, especially for dyeing aqueous foods, generally cannot be used directly as feed additives or as active compounds in cosmetics. Hig...

Claims

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Application Information

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IPC IPC(8): B01J2/08A23K1/00A23K1/16A23K1/20A23L1/00A23L1/275A23L5/40A23L33/155A23P1/06A61K8/04A61K8/11A61K8/30A61K8/31A61K8/34A61K8/35A61K9/14A61K9/16A61K9/50A61K9/51A61K31/01A61K31/015A61K31/045A61K31/522A61Q1/12C07C11/21C07C403/24
CPCA61K9/146A61K8/35A23K1/001A23K1/1606A61K9/1658A61Q1/12A61K8/11A23K1/002A23L1/2753A61K9/5169A23P1/06A23L1/0035A23K1/004A23V2002/00A23K1/1603A23L1/303A61K8/31A23K1/003A61K2800/412A61K31/522A23K20/174A23K20/179A23K40/00A23K40/10A23K40/25A23K40/30A23L5/44A23L33/155A23P10/40A61P3/02A23V2250/54246A23V2250/213A23V2250/211B01J2/08B82Y40/00A23K40/20
Inventor H·奥维特H·波恩E·吕德克W·辛茨F·伦格A·-M·普菲菲
Owner BASF AG
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