Targeting multimeric imaging agents through multilocus binding

A contrast agent and multi-site technology, which is applied in the field of contrast enhancement, new multi-body compounds, and contrast agents for diagnostic imaging, can solve the problems of increasing contrast, reducing flexibility, and large background of rigid contrast agents, so as to improve imaging contrast and imaging Effect of Contrast Improvement
CN1382062AInactive Publication Date: 2002-11-27EPIX PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
EPIX PHARMA
Publication Date
2002-11-27
Estimated Expiration
Not applicable · inactive patent
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Abstract

The present invention relates to contrast agents for diagnostic imaging. In particular, the present invention relates to novel multimeric compounds that exhibit improved relaxation rates when binding endogenous proteins or other physiologically relevant sites. Such compounds include: a) two or more image-enhancing moieties (“IEMs”) (or signal-generating moieties) comprising multimeric subunits; b) two or more target-binding moieties (“TBMs”) that provide In vivo positioning and multibody rigidification; c) a framework ("backbone"); and d) an optional linker for attaching the IEMs to the framework. The invention also relates to pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions to enhance contrast in diagnostic imaging.
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Description

field of invention

[0001] The present invention relates to contrast agents for diagnostic imaging. In particular, the present invention relates to novel multimeric compounds which, upon binding, exhibit improved affinity to physiologically relevant targets, such as proteins, and surprisingly improved relaxivity properties. Such compounds include:

[0002] a) two or more image-enhanced segments (“IEMs”);

[0003] b) two or more target-binding moieties ("TBMs") that provide in vivo localization and multibody rigidification;

[0004] c) the frame ("skeleton");

[0005] d) An optional linker ("linker") that attaches the IEMs to the framework.

[0006] The invention also relates to pharmaceutical compositions comprising these compounds, and the use of these compounds and compositions for contrast enhancement in imaging processes. Background of the invention

[0007] Diagnostic imaging methods, such as magnetic resonance imaging (MRI), X-rays, nuclear radiopharmaceutical imag...

Claims

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