Skin preparations for extenal use
A technology for skin and topical preparations, used in skin care preparations, skin diseases, cosmetic preparations, etc., and can solve problems such as unsatisfactory effects, thermal and oxidative instability, and instability
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preparation Embodiment 1
[0050] In order to prepare the compositions shown in Table 1, the α-arbutin prepared in the above examples (hereinafter, the term "α-arbutin" should always indicate the α-arbutin), methyl p-hydroxybenzoate The ester and butyl p-hydroxybenzoate are added to a mixture of purified water and propylene glycol, and the above mixture is heated to 80°C to dissolve.
[0051] The mixture of other ingredients shown in Table 1 was uniformly dissolved by heating to 80° C., gradually added to the above solution, and the obtained mixture was emulsified at high speed using a homogenizer-mixer.
[0052] After emulsification, the mixture was gradually cooled to 30°C with stirring to prepare an ointment.
[0053] Table 1
[0054] weight ratio%
[0055] Alpha-Arbutin 2.0
[0056] Vaseline 4.0
[0057] Stearyl Alcohol 5.0
[0058] Liquid paraffin 17.0
[0059] POE(20) cetyl ether 4.0
[0060] Glyceryl Monos...
preparation Embodiment 2
[0065] To prepare the composition formulations shown in Table 2, α-arbutin was added to purified water and dissolved at 70°C. The resulting solution was maintained at this temperature.
[0066] On the other hand, the other ingredients in Table 2 were mixed, maintaining a temperature of 70°C. The above-mentioned mixture of α-arbutin and purified water at 70°C was added to the mixture of other ingredients maintained at 70°C, and the resulting mixture was cooled under stirring to prepare a cream.
[0067] Table 2
[0068] weight ratio%
[0069] Alpha-Arbutin 1.0
[0070] Polyethylene glycol isostearate 7.5
[0071] Cetyl Alcohol 1.0
[0072] Liquid paraffin 7.5
[0073] Isopropyl myristate 7.5
[0074] Diethylene glycol monoethyl ether 10.5
[0075] Parabens 0.5
[0076] Propylene Glycol 5.0
[0077] purified water balance
preparation Embodiment 3
[0079] To prepare the compositions in Table 3, α-arbutin was added to purified water, dissolved at a temperature of 70°C, and the solution was maintained at this temperature.
[0080] On the other hand, the other ingredients in Table 3 except locust bean gum were mixed and maintained at 70°C.
[0081] The above mixture of α-arbutin and purified water maintained at 70°C was added to the mixture of other ingredients maintained at 70°C. The resulting mixture was stirred well, cooled to 50°C, homogenized, and continued cooling to 30°C.
[0082] Add locust bean gum to the above mixture, cool to 30°C, stir the resulting mixture, and prepare an emulsion after cooling.
[0083] table 3
[0084] Percent by weight α-Arbutin 0.05 Polyoxyethylene sorbitan monostearate 5.0 Sorbitan monostearate 3.0 Glycerol monostearate 2.0 Cetyl alcohol 2.5 Isopropyl myristate 8.0 Parabens 0.5 Propylene Glycol 2.0 Locust Bean Gum 2.0 Pu...
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