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Cranesbill total flavonoid extract and use in preparation of anti-virus medicine

A technology of total flavonoids and extracts, which is applied in the field of preparation of antiviral drugs, antiviral drugs, and total flavonoids extracts from geranium, and can solve the problems of geranium drugs and antiviral effects that have not been seen

Inactive Publication Date: 2003-08-06
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Taking a comprehensive view of the reports at home and abroad, there is no total flavonoid extract of the dry aerial part of Gerancium carolinianum L, its medicine and antiviral efficacy.

Method used

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  • Cranesbill total flavonoid extract and use in preparation of anti-virus medicine
  • Cranesbill total flavonoid extract and use in preparation of anti-virus medicine
  • Cranesbill total flavonoid extract and use in preparation of anti-virus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Take 300 grams of the dry above-ground raw medicinal materials of pang geranium (Gerancium carolinianum L) produced in China, extract three times with 50% alcohol, concentrate the extract to 1 / 4-1 / 5 volume, and apply it to D101 macropore Resin, eluted with water and 70% alcohol, collected eluate, verified by magnesium powder / hydrochloric acid detection, collected the part with high flavonoid content, concentrated the eluate to dry to obtain the product of solid effective part, weighed, and determined the total flavonoids, The product yield of the effective part is over 1%, and the total flavonoid content exceeds 50%. Table 4 is the yield and content of the total flavonoids of Geranium.

[0056] Table 4

[0057] Lot 1 2 3 Average

[0058] Product yield (grams) 3.36 3.61 4.30 3.76

[0059] Total flavonoids (g) 2.28 1.95 3.30 2.51

[0060] Product yield % 1.12 1.20 1.43 1.25

[0061] Total flavonoid content% 67.9 54.0 76.7 66.7

Embodiment 2

[0063] Take 50 grams of geranium total flavonoids extract, crush it through a 100-mesh sieve, add 3 grams of starch and mix evenly, then add 10% starch slurry in an appropriate amount to make a soft material, granulate with a 20-mesh sieve, dry at 60-70 ° C, pass through Sieve through a 30-mesh sieve, add 3 grams of hydroxypropyl cellulose and 1 gram of magnesium stearate, mix thoroughly, press into tablets, and film-coat to obtain 1,000 tablets. Each tablet contains 50mg of total flavonoid extract.

Embodiment 3

[0065] Take 50 grams of geranium total flavonoids extract, crush it through a 100-mesh sieve, add 3 grams of starch, appropriate amount of microcrystalline fiber, granulate with dilute ethanol, granulate with a 20-mesh sieve, dry at 60-70°C, granulate, add Appropriate amount of magnesium stearate, fully mixed, filled into capsules, 1000 capsules,

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Abstract

The present invention relates to a cranesbill total flavone extract and its application in preparation of anti-virus medicine. The external and internal tests show that it has the action of inhibit herpes virus, influenza virus, hepatitis B virus and AIDS virus. Said invented cranesbill total flavone extract and its extract effective component quercetin-3-O-beta-D-galactopyranose and added auxiliary material can be made into the dosage forms of capsule, tablet, grnaules and injection for curing viral hepatitis, viral influenza, herpes virus infection and AIDS virus infection.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to an antiviral drug, in particular to an extract of geranium total flavonoids and its application in preparing antiviral drugs. Background technique: [0002] The Chinese herbal medicine geranium includes long mouth, short mouth and wild geranium. Its main components are tannins, organic acids, volatile oils and flavonoids. Arthralgia, numbness and spasm, muscle and bone pain, diarrhea and dysentery, etc. At present, its commonly used preparation is geranium ointment. Before the 1990s, it was considered that geranium was a seldom-used drug, but in recent years, there have been many research reports on geranium. In 1997, it was reported abroad that the anti-infective active substance was isolated and extracted from the root of Geranium Sanguineum L, which contained a compound of flavonoid catechin, tannic acid and carboxylic acid, which can inhibit multiple diseases in v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/12A61P31/16A61P31/18A61P31/22C07H1/08C07H17/07
Inventor 周珮李继扬黄海钮君健戴培兴
Owner FUDAN UNIV
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