Method for preparing high density core material coated with thin shell medium of agarose gel

Abstract

The present invention discloses the technology of preparing gel carrier microballoon with loaded inert grain. The preparation process includes preparing suspension, emulsifying and coating reaction, and curing and crosslinking process. The preparation process features that the glass bead is dispersed inside the water solution of agarose to prepare suspension; the suspension is then added into salad oil while adding emulsifier Span-80 and stirring for emulsification and coating reaction to lower temperature fast to form microballoon; and epoxy chloropropane is then added for crosslinking at alkaline condition and sodium borohydride is added for reduction to prepare dispersed medium with particle size 40-500 mincrons and agerose content 20-70 wt%. The dispersed medium exhibits certain density and particle size distribution and has high density in expanding bed, column efficiency, adsorption capacity and thus wide application.

Description

technical field

[0001] The invention relates to an oil-water two-phase method for preparing a high-density nuclear material surface-wrapped agarose gel thin shell medium, which belongs to the microsphere preparation technology in which inert particles are loaded in a gel carrier. Background technique

[0002] Expanded bed technology is a new type of integrated biological separation operation technology that gradually emerged in the early 1990s. It has the advantages of small backmixing, high void ratio, pressure drop, high column efficiency, and large processing capacity. It has been used in the separation process of biological macromolecules. been widely applied. The operating performance of expanded bed adsorption depends on whether a stable bed with low back-mixing and high column efficiency can be formed, and a stable bed is achieved by a medium with a certain density and particle size distribution. Therefore, the expanded bed adsorption techno...

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