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Spherical amino acid adsorbent and its preparation method

An amino acid and adsorbent technology, applied in the field of spherical amino acid adsorbent and its preparation, can solve the problems of high manufacturing cost of the adsorbent, unacceptable to patients, poor blood compatibility, etc., and achieves low production cost, no toxic side effects, and low cost Effect

Active Publication Date: 2004-02-25
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Protein A as a ligand is relatively expensive, which makes the production cost of the adsorbent relatively high; at the same time, this kind of adsorbent has poor blood compatibility, and the patient's blood must be separated from the plasma before it can be adsorbed. perfusion therapy
This results in the high cost of clinical hemoperfusion therapy at present, although it has a clear curative effect, it cannot be accepted by most patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (a) Preparation of cellulose support

[0042] 10 g of refined cotton was alkalized with 19% sodium hydroxide aqueous solution for more than two hours at room temperature, and after removing the lye, it was placed in a sealed place at 28° C. for aging for three days.

[0043] Add 6g CS 2 , shaking at 25°C for 10 h to obtain an orange viscose solution. Add 6% NaOH to make the weight of the above-mentioned viscose liquid reach 100g, and set aside.

[0044] Using 300ml of chlorobenzene and 1.2g of potassium oleate as the dispersion medium, add viscose liquid to it, and synthesize spherical cellulose by suspension polymerization. Raise the temperature to 80° C. and keep it warm for 3 hours. After that, pour off the organic solvent to wash the synthesized carrier. Collect the components with a particle size in the range of 0.45-0.9mm, and store them in water at 4°C for later use. The yield is greater than 80%.

[0045] (b) Activation of cellulose support

[0046] The ca...

Embodiment 2

[0052] Example 2. According to Example 1, the fixed amount of tryptophan was 36.4 μmol / ml. The adsorption capacity of rheumatoid factor is 122.4IU / ml.

Embodiment 3

[0053] Example 3. According to Example 1, the fixed amount of leucine was 30.6 μmol / ml. The adsorption capacity for rheumatoid factor is 61.0IU / ml.

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Abstract

The present invention relates to a ring amino acid adsorbing agent and its preparation method. It uses natural macromolecule as carrier, its grain size is 0.45-0.9 mm, it is formed from resin which has amino acid ligand with fixed effective dose after activation of epoxy chloropropane, in which amino acid content is 12.5-39.7 micro mol / ml resin, and the described ligand is: amino acid, polyamino acid, polypeptide or protein. It can be directly used for blood perfusion method to cure the diseases of rheumatoid arthritis, systemic lupus erythematosus, myasthenia gravis, endotoxemia and infective shock, etc. The animal tests show that adsorbing agent has no toxic side effect and heat source. It is a good medical blood-cleaning adsorption material.

Description

technical field [0001] The invention relates to a medical adsorption material, in particular to a spherical amino acid adsorbent and a preparation method thereof, which are applied to hemoperfusion to treat difficult diseases. A variety of amino acids are chemically bonded to spherical natural polymer carriers to become medical adsorbents with amino acid ligands, which can be used for hemoperfusion therapy to treat rheumatoid arthritis, systemic lupus erythematosus, myasthenia gravis, and Diseases such as endotoxemia and septic shock. Background technique [0002] Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), myasthenia gravis (MG), endotoxemia, and septic shock are clinically refractory diseases. Among them, rheumatoid arthritis, systemic lupus erythematosus, and myasthenia gravis are all autoimmune diseases, and their pathogenic mechanisms are not very clear. So far, there is no effective treatment method or drug at home and abroad. Steroidal analgesics ...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14A61M1/34
Inventor 俞耀庭王永健魏佼
Owner JAFRON BIOMEDICAL
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