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Controlled release preparation for nitrendipine

A technology for nitrendipine and preparations, applied in the field of controlled release preparations, can solve the problems of severe blood pressure fluctuation, high T/P ratio, changes in blood drug concentration, etc. Concentration level effect

Inactive Publication Date: 2004-09-01
王颖 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Scientific research has found that simple high blood pressure can cause damage to organs, but blood pressure fluctuations are especially serious.
Nitrendipine preparations are currently ordinary tablets, which need to be taken three times a day. Although this preparation can achieve the purpose of lowering blood pressure, due to the severe changes in blood drug concentration, the high T / P ratio, severe blood pressure fluctuations, and organ injury

Method used

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  • Controlled release preparation for nitrendipine
  • Controlled release preparation for nitrendipine

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Experimental program
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specific Embodiment

[0008] Specific embodiment, medicine preparation: (mg / tablet)

[0009] Nitrendipine 30, sodium chloride 50, sucrose 30, starch 10, cellulose acetate 30, polyethylene glycol 30. According to the prepared formula, nitrendipine, sodium chloride, sucrose, and starch were crushed and sieved separately, mixed evenly and added with binder to make soft material; then granulated with a 20-mesh sieve, dried; granulated with a 16-mesh sieve, The dry granules are added with appropriate amount of lubrication to make the drug core; the polyethylene glycol is dissolved in the mixed solution of acetone and ethanol, and cellulose acetate is added to make the coating liquid; the drug core is coated in a centrifugal coating pot, and the Make a small hole about 0.55mm on the coating film. And experiment in Fig. 1, find that the nitrendipine controlled-release tablet prepared according to the present invention can release at a substantially constant rate, and maintain the curative effect for 24 ...

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Abstract

The invention relates to a controlled release formulation for constant speed releasing Nitrendipine, wherein the medicament is released at a constant speed, and the blood medicament concentration waves smoothly. The release sheet is a single-chamber infiltration pump comprising the two portions of a powder core containing Nitrendipine and preparation formed by semipermeable membrane with minipores and having permeability only for small molecules such as that of water (mg / part), Nitrendipine 10-50, osmoregulation agent 3-80, propelling agent 1-50, bonding agent 1-20, right amount of lubricating agent, while the semipermeable membrane comprises semi-permeable membrane material 1-50 and aperture making agent 1-50. The invention can realize constant speed release, thus achieving the goal of smooth hypertension.

Description

technical field [0001] The invention relates to a controlled release preparation of nitrendipine with constant release rate. Background technique [0002] Nitrendipine (nitrendipine) is a second-generation calcium antagonist developed in the 1980s. It is a calcium antagonist that selectively acts on vascular smooth muscle, and its selective effect on coronary arteries is better. It can reduce myocardial oxygen consumption and has a protective effect on ischemic myocardium. It can reduce the total peripheral resistance and lower blood pressure. Indications for hypertension, especially for hypertensive patients with coronary heart disease. It can be used to treat coronary heart disease and high blood pressure, and can also be used for congestive heart failure. The half-life of nitrendipine is very short. After oral administration of 30 mg, the plasma concentration reaches its peak within 30 minutes. In plasma, its binding rate to plasma protein is about 98%. T 1 / 2 About ...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/4422A61P9/12
Inventor 王颖侯峻冰
Owner 王颖
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