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Method for preparing bioceramic and biodegradable aliphatic polyester composite materials

A technology of aliphatic polyester and bioceramics, which is applied in the treatment of dyed polymer organic compounds, etc., can solve the problems of limiting the application range of composite materials, high toxicity of isocyanate, and small amount of covalent bonds, so as to improve instability, Uniform and stable dispersion, excellent biological activity

Inactive Publication Date: 2005-06-29
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is far from meeting the requirements of practical applications. The toxicity of isocyanate is very high. Its addition limits the application range of composite materials and is not environmentally friendly. Moreover, the hydroxyapatite particles actually obtained in the composite materials obtained by this method —Isocyanate—the polymer molecular chain has a small amount of covalent linkage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of modified hydroxyapatite nanoparticles grafted with glycolic acid on the surface. In three reaction bottles, 15g of hydroxyapatite (HA) nanoparticles (about 20-50nm in diameter) were dispersed in 150ml of toluene solvent, and 7.5g, 15g, and 30g of glycolic acid (GAc) were added respectively. The reaction was stirred at 60° C. for 3 hours, and then the reaction was continued for 10 hours under the condition of toluene azeotropic dehydration. The product was repeatedly washed with chloroform and ethanol five times to remove unloaded glycolic acid, and dried in vacuum at 40° C. for 48 hours to obtain modified hydroxyapatite nanoparticles with glycolic acid loaded on the surface. Infrared spectroscopy can verify the chemical connection between glycolic acid and nanoparticles, and the loading amount of glycolic acid on nanoparticles obtained by thermogravimetric method is shown in Table 1.

[0028]

Embodiment 2

[0030] In Example 1, tricalcium phosphate (TCP) was used to replace hydroxyapatite, and the test steps and methods were the same as in Example 1. The results of the content of glycolic acid grafted on the surface of tricalcium phosphate are shown in Table 2.

[0031]

[0032] 2

Embodiment 3

[0034] Solvent-free direct preparation of modified hydroxyapatite nanoparticles grafted with glycolic acid on the surface. In three reaction flasks, mix 15g of hydroxyapatite (HA) nanoparticles (about 20-50nm in diameter) with 7.5g, 15g, and 30g of glycolic acid (GAc), and stir at 80-120°C. React for 5 hours. The product was repeatedly washed with chloroform and ethanol five times to remove unloaded glycolic acid, and dried in vacuum at 40° C. for 48 hours to obtain modified hydroxyapatite nanoparticles with glycolic acid loaded on the surface. Glycolic acid loading is shown in Table 3.

[0035]

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Abstract

The invention has supplied a method to prepare aliphatic polyester compound material of biological ceramic and biological degradation. Biological ceramic nm / mm particle reacts with glycolic acid in the dehydrating condition of boiling with toluene, or with biological ceramic and glycolic acid in inorganic solvent. By graft on the surface of the biological ceramic particle, acquire the chemical strycture of -biological ceramic, then without water and oxygen, with stannous octoate as initiator, initiate hydroxyl group of glycolic acid loaded with caprolactone, lactide, diglycolide and cyclic ester, acquiring the product of them and nm / mm compound material of copolymer. The biological ceramic modified by glycolic acid and loaded with polyester of surface graft can be used for polyester material directly.

Description

technical field [0001] The invention relates to a preparation method of a bioceramic and biodegradable aliphatic polyester composite material. Background technique [0002] Aliphatic polyesters, such as polylactide (PLA), polyε-caprolactone (PCL), and polyglycolide (PGA), are currently a class of fully biodegradable materials that are widely used. Aliphatic polyester has low immunity and good biodegradability, biocompatibility and mechanical strength, so it is widely used in biomedical and medical fields, such as: fracture fixation materials, surgical sutures, tissue engineering scaffold materials, drugs Sustained-release carrier materials, etc. [0003] Bioceramics (hydroxyapatite, tricalcium phosphate) are good degradable bone substitute materials, and almost no adverse reactions occur in the human body. A large number of literatures have reported that osteoblasts are easier to grow on bone-like bioceramics. The osseointegration ability of pure polylactic acid is low, an...

Claims

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Application Information

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IPC IPC(8): C08G63/78C08K3/26C08L67/00C09C3/10
Inventor 陈学思邱学宇孙敬茹洪重奎胡俊丽刘爱学边新超
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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