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Preparation of pinellia decoction for purging stomach fire, its preparing method and application

A Banxia Xiexin Decoction and preparation technology, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of large impact on gastric emptying of drugs, large dosage, inconvenient treatment and use, etc., to achieve Good curative effect, less dosage, convenient to take

Inactive Publication Date: 2005-11-23
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved in the present invention is to disclose a preparation of Banxia Xiexin Decoction and its preparation method and application, so as to overcome the problems in the prior art that the dosage is large, the medicine is also greatly affected by gastric emptying, and it is used for the treatment of patients. inconvenient defect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 2kg of medicinal materials according to the prescription of Banxia Xiexin Decoction, of which:

[0024] Medicinal Pinellia 0.46kg, Scutellaria baicalensis 0.33kg, Ginseng 0.33kg, Dried Ginger 0.32,

[0025] Jujube 0.32kg, Zhilicorice 0.19kg, Coptis 0.05kg

[0026] Use 36kg of 70% ethanol solution, heat and reflux in a water bath to extract twice, add 20kg for the first time, extract for 2h, add 16kg for the second time, extract for 1h; filter, and the relative density of the filtrate when concentrated to 25°C is 1.1, spray-dried to obtain Extract powder. The extract powder was sieved, added 148g of microcrystalline cellulose, 26g of polyvinylpyrrolidone and 26g of sodium carboxymethylcellulose, granulated by dry pressing, and filled with capsules to make Banxia Xiexin Capsules.

Embodiment 2

[0028] Weigh 2kg of medicinal materials according to the prescription of Banxia Xiexin Decoction, of which:

[0029] Medicinal Pinellia 0.40, Scutellaria baicalensis 0.31, Codonopsis 0.32, dried ginger 0.32,

[0030] Jujube 0.31, Radix Glycyrrhiza 0.21, Coptis 0.13.

[0031] Use 44kg of 60% ethanol solution, heat and reflux in a water bath to extract twice, add 24kg for the first time, extract for 2h, add 20kg for the second time, extract for 1h; filter, the relative density of the filtrate when concentrated to 25°C is 1.1, and spray dry to obtain Extract powder. The extract powder was sieved, added 148g of microcrystalline cellulose, 26g of polyvinylpyrrolidone and 26g of sodium carboxymethylcellulose, granulated by dry pressing, and filled with capsules to make Banxia Xiexin Capsules.

Embodiment 3

[0033] Adopt the method of Example 2, and granulate by dry pressing method known in the art, add magnesium stearate 4g tabletting after granulation, make Pinellia Xiexin Tablet, acrylic resin adopts known method film-coating for tablet Clothes.

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PUM

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Abstract

The invention discloses a preparation of pinellia decoction for purging stomach fire, its preparing method and application, wherein the preparation comprises using compound pinellia decoction as raw medicinal materials, extracting effective substances with water or ethanol, preparing powdered extract through spray drying or decompression drying, charging medicinal auxiliary materials and preparing granule through dry method palletizing or wet method palletizing, finally filling into capsule or carrying pelleting to form the tablet. The preparation has good curative effect for superficial gastritis especially gastritis caused by Helicobacter pylori, and gastric ulcer, the invention also has the advantages of easy administration and small amount of dosage.

Description

technical field [0001] The invention relates to a Chinese medicine compound Banxia Xiexin Decoction preparation and a preparation method thereof, in particular to capsules and tablets which take the Chinese medicine compound Banxia Xiexin Decoction as an active ingredient. Background technique [0002] Superficial gastritis is a common and frequently-occurring disease with a long course and easy recurrence. Western medicine generally adopts triple or quadruple therapy, which has high treatment costs and large side effects. Banxia Xiexin Decoction is a classic prescription in "Treatise on Febrile Diseases" written by Zhang Zhongjing. It is a common prescription for modern Chinese medicine clinical treatment of chronic gastritis and gastric ulcer. It has good curative effect, low recurrence rate and few side effects, but there is no such prescription The preparation is on the market, and it is taken in decoction in clinical application. The dosage is large, and the medicine is...

Claims

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Application Information

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Inventor 奉建芳李妍祝林
Owner SHANGHAI INST OF PHARMA IND
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