Total flavone glycoside extract of Radix scutellariae, Rodix scutellariae monomer flavone glycoside, its preparation and use

A technology for total flavonoid aglycone and baicalein flavonoid glycosides, applied in the direction of organic chemistry and the like, can solve the problems of affecting potential effect, unsuitable for industrial production, low yield and the like, and achieves mild reaction conditions, low production cost and high product yield. Effect

Inactive Publication Date: 2005-12-21
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although baicalein has many specific pharmacological effects, its preparation technology is very difficult, and it is difficult to carry out large-scale industrial production, so it cannot meet the needs of preparations and clinics, which affects its potential effects.
The methods currently used for the preparation of baicalein mainly include: 1. extracting and separating baicalein from Scutellaria baicalensis, because the content of free baicalein in scutellaria baicalensis is low, generally between 0.1% and 0.5%, so it basically does not

Method used

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  • Total flavone glycoside extract of Radix scutellariae, Rodix scutellariae monomer flavone glycoside, its preparation and use
  • Total flavone glycoside extract of Radix scutellariae, Rodix scutellariae monomer flavone glycoside, its preparation and use
  • Total flavone glycoside extract of Radix scutellariae, Rodix scutellariae monomer flavone glycoside, its preparation and use

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Take the dried Scutellaria baicalensis root, crush it, pass it through a No. 4 sieve, weigh 100g of the powder, add 120ml of 41°C water, stir evenly, put it in a 41°C water bath, cover it and keep it at a constant temperature of 41°C for 4.2 hours, take it out, and put it in hot air at 80°C dry. Put the dry powder in a Soxhlet extractor, add absolute ethanol to heat and reflux for extraction, and recover the solvent under reduced pressure. The residue was collected, pulverized, and sieved to obtain 12.8 g of total flavonoid aglycone extract of Scutellaria baicalensis, which contained 7.8 g of baicalein and 11.3 g of total flavonoid aglycone of Scutellaria baicalensis.

Embodiment 2

[0025] Take the dried Scutellaria baicalensis root, crush it, pass it through a No. 4 sieve, weigh 100g of the powder, add 120ml of 42°C water, stir evenly, put it in a 42°C water bath, cover it and keep it at a constant temperature of 42°C for 4.2 hours, take it out, and put it in hot air at 80°C dry. Put the dry powder in a Soxhlet extractor, add absolute ethanol to heat and reflux for extraction, and recover the solvent under reduced pressure. The residue was collected, pulverized, and sieved to obtain 12.6 g of total flavonoid aglycone extract of Scutellaria baicalensis, which contained 7.7 g of baicalein and 11.1 g of total flavonoid aglycone of Scutellaria baicalensis.

Embodiment 3

[0027] Take the dried Scutellaria baicalensis root, crush it, pass it through a No. 4 sieve, weigh 100g of the powder, add 110ml of 45°C water, stir evenly, put it in a 45°C water bath, cover it and keep it at a constant temperature of 45°C for 4.2 hours, take it out, and put it in hot air at 60°C dry. Put the dry powder in a Soxhlet extractor, add absolute ethanol to heat and reflux for extraction, and recover the solvent under reduced pressure. The residue was collected, pulverized, and sieved to obtain 12.9 g of total flavonoid aglycone extract of Scutellaria baicalensis, which contained 7.8 g of baicalein and 11.2 g of total flavonoid aglycone of Scutellaria baicalensis.

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Abstract

This is a kind of baicalin total flavones glucoside distillation, baicalin monomer flavones glucoside and its preparation method and application, belonging to the Chinese native medicine drugs manufacturing technology field. The invention obtains the baical in total flavones glucoside distillation mainly containing biacalein, or baical in flavones glucoside monomer compound mainly containing biacalein or wogonoside or oroxylin; comminute baixcal, add water, have alcoholysis reaction at 41 -46 Deg. C, the baialinase and baicalin flavones glucoside naturally existing in baixcal directly have alcoholysis reaction without distillation and separation. The pharmacy preparation includes various pharmacy preparations comprised of officinal auxiliary materials with baicalin total flavones glucoside distillation or monomer flavones glucoside as pharmacy active components, and are used to prepare drugs for curing liver diseases and AIDS. The reaction condition of the invention is mild, and it has high distilling rate, good product quality, low energy waste simple craft, no pollution and low production cost.

Description

(1) Technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to an extract of total flavonoid aglycone from Scutellaria baicalensis, monomeric flavone aglycon from Scutellaria baicalensis, a preparation method and application thereof. (2) Background technology [0002] Scutcllaia Baicalensis Ceorgi is the dry root of Scutellaria baicalensis, a plant in the Labiatae family. It is a traditional Chinese medicine used for damp-heat diarrhea, cough due to lung heat, fever and polydipsia, jaundice, red eyes, swelling and pain, accumulated heat and hematemesis, fetal movement, and pain. Canker sore embolism. Traditional Chinese medicine is compatible with Scutellaria baicalensis in many important prescriptions for the treatment of viral hepatitis B, such as: Sanwu Huangqin Decoction, Qinggan Granules, Yigan Jiedu Capsules, etc., indicating that Scutellaria baicalensis has the effect of treating hepatitis B. Traditional Chine...

Claims

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Application Information

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IPC IPC(8): C07D311/30
Inventor 程秀民
Owner SHANDONG UNIV
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