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Chinese materia medica preparation for treating diabetic nephropathy, and preparation method

A technology for diabetic nephropathy and traditional Chinese medicine preparations, which is applied in pharmaceutical formulations, urinary system diseases, and medical preparations containing active ingredients, etc. Adverse reactions, significant effects, fast-acting effects

Inactive Publication Date: 2006-02-01
浙江省中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These factors may include: poor blood sugar control, biochemical changes, genetic factors, excessive protein intake, hypertension, excessive secretion of growth hormone and glucagon, abnormal fat metabolism, etc. no effective treatment
Western medicine advocates comprehensive measures such as controlling blood sugar, lowering blood pressure, eating a low-protein diet, and using aldose reductase inhibitors, but they can only improve the early stage of DN. No significant effect
At present, the Chinese patent medicines used for DN mainly include Shenfukang Capsules and Shenyanfufu Tablets, etc., but the curative effect is not ideal due to the lack of specificity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 460g of astragalus, 460g of kudzu root, 460g of Ganoderma lucidum, 460g of Ligustrum lucidum, 460g of salvia miltiorrhiza, add 8 times the amount of water to decoct for 2 hours, filter, add 370g of rhubarb, add 8 times the amount of water to decoct for 2 hours, combine the decoction, let stand Set aside for 24 hours, take the supernatant and microfilter, concentrate the filtrate to a relative density of 1.10-1.20 (50°C), add ethanol to make the alcohol content reach 80%, refrigerate for 24 hours, filter, and recover ethanol from the filtrate under reduced pressure, precipitate at low temperature After drying, heat water to dissolve, high-speed centrifugation (14000r / min), the supernatant is combined with the medicinal solution after recovering ethanol, and concentrated to an extract with a relative density of 1.25-1.30 (50°C), take the above extract, add Lactose 500g, dextrin 100g, adopt the boiling granulation method to make granule, check, pack promptly to obtain ...

Embodiment 2

[0019] Take 530g of astragalus, 530g of kudzu root, 530g of ganoderma lucidum, 530g of privet lucidum, and 530g of salvia miltiorrhiza, add 8 times the amount of water to decoct for 2 hours, filter, add 350g of rhubarb, add 8 times the amount of water to decoct for 2 hours, combine the decoction, let stand Set aside for 24 hours, take the supernatant and microfilter, concentrate the filtrate to a relative density of 1.10-1.20 (50°C), add ethanol to make the alcohol content reach 80%, refrigerate for 24 hours, filter, and recover ethanol from the filtrate under reduced pressure, precipitate at low temperature After drying, heat water to dissolve, high-speed centrifugation (14000r / min), the supernatant is combined with the medicinal solution after recovering ethanol, concentrated to an extract with a relative density of 1.25-1.30 (50°C), vacuum-dried, pulverized, added The starch of 10% dry cream powder amount is mixed evenly, packs capsule, makes 1000, promptly obtains capsule o...

Embodiment 3

[0021] Take 620g of astragalus, 620g of kudzu root, 620g of Ganoderma lucidum, 620g of Ligustrum lucidum, and 620g of salvia miltiorrhiza, add 8 times the amount of water to decoct for 2 hours, filter, add 400g of rhubarb, add 8 times the amount of water to decoct for 2 hours, combine the decoction, let stand Set aside for 24 hours, take the supernatant and microfilter, concentrate the filtrate to a relative density of 1.10-1.20 (50°C), add ethanol to make the alcohol content reach 80%, refrigerate for 24 hours, filter, and recover ethanol from the filtrate under reduced pressure, precipitate at low temperature After drying, heat water to dissolve, high-speed centrifugation (14000r / min), the supernatant is combined with the medicinal solution after recovering ethanol, concentrated to an extract with a relative density of 1.25-1.30 (50°C), vacuum-dried, pulverized, added The lactose of 3% dry cream powder, 6% sodium carboxymethyl starch, 3% microcrystalline cellulose, 0.5% medic...

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PUM

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Abstract

A Chinese medicine in the form of particle, capsule, or tablet for treating diabetes and nephrosis is prepared from astragalus root, pueraria root, ganoderma, lucid ligustrum fruit and red sage root, through decocting, filter, adding rhubarb, decocting, collecting decoction, laying aside, taking supernatant, filter, concentrating, adding alcohol, cold storage, filter, recovering alcohol, low-temp baking of deposit, dissolving in hot water, centrifugal separation to obtain supernatant, mixing it with the liquid after recovering alcohol, concentrating, adding auxiliary, and shaping.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] With economic development, changes in people's lifestyles and population aging, the number of diabetic patients is increasing rapidly, and its incidence is gradually increasing worldwide, especially in developing countries, where the increase is faster and the prevalence is trending. [0003] Diabetic nephropathy (DN) is a common and refractory complication of diabetes. The main pathological changes are the thickening of the glomerular basement membrane and the accumulation of extracellular matrix mainly in the glomerular mesangial area, resulting in diffuse or nodal nephropathy. Nodular glomerulosclerosis. Diabetic nephropathy is one of the main causes of death in diabetic patients. According to reports, diabetic nephropathy accounts for 40% of all newly diagnosed end-stage renal disease...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/20A61P3/10A61P13/12
Inventor 杨苏蓓柴可夫王溶溶杨明华汤建成徐强
Owner 浙江省中药研究所有限公司
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