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Technique for preparing pharmaceutical product of Breviscapine

A technology for preparing scutellarin and its preparation technology, which is applied in the field of preparation technology of raw materials, can solve the problems of improving the purity of scutellarin and eliminating side effects that have not been reported, and achieves easy industrial production, solving instability, and process Effects in simple steps

Active Publication Date: 2006-02-01
KUNMING LONGJIN PHARMA
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  • Abstract
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Problems solved by technology

There is no report on the refining process of scutellarin in the relevant literature and patent materials, and there is no report on the improvement of the purity of scutellarin and the elimination of side effects

Method used

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  • Technique for preparing pharmaceutical product of Breviscapine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] Weigh 1000g of commercially available scutellarin crude drug, add 5 times the weight of water, adjust the pH value to 7 with 25% sodium metaphosphate test solution, dissolve completely, filter, add 8 times of acetone to the filtrate to precipitate, stir while adding, Make the precipitation complete, stand still for 10 hours, filter, add acetone to wash three times, then move the precipitate to another container, add 5 times the amount of 30% acetone, stir well, add 20% hydrochloric acid to adjust the pH to 1-2 and let stand After 10 hours, filter with suction, wash with water until neutral, wash once with ethanol, and dry to obtain refined scutellarin. The content of scutellarin by HPLC analysis is 99.5315%, as shown in the attached drawing.

[0022] Detection method: chromatographic conditions and system suitability test (using octadecyl bonded silica gel as filler: methanol-0.1% phosphoric acid solution (40:60) as mobile phase; detection wavelength is 335nm. The number...

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Abstract

A process for preparing the high-purity raw breviscapine B includes such steps as loading the breviscapine in a container, adding water, adding pH regulator chosen from 15 compounds including sodium meta-phosphate, potassium meta-phosphate, sodium hypophosphate, potassium hypophosphate, etc to regulate pH=4-8, adding solvent, depositing, laying aside, filter, washing the deposit by solvent, transferring the deposit to a solvent solution, acidifying, filter, water washing and drying.

Description

technical field [0001] The invention relates to a preparation process of a bulk drug in the pharmaceutical industry, in particular to a preparation process of a high-purity bulk drug. Background technique [0002] Erigeron breviscapus (Vant.) Hand-Mazz is a flavonoid active ingredient isolated from the whole herb of Erigeron breviscapus (Vant.) Hand-Mazz, mainly scutellarin (also known as breviscapus, scutellarin, hereinafter referred to as B) , the chemical name is 4′5,6-trihydroxyflavone-7-O-glucuronide. The breviscapine raw material drug purchased from the market is analyzed by HPLC, and the content of B is about 90%. This preparation has been widely used clinically to treat cardiovascular and cerebrovascular diseases, and its curative effect is remarkable. However, its injection has poor stability and short storage time. Clinically, individual patients may experience cold and heat reactions, skin itching, and rashes after use. The appearance of the phenomenon is mainly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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