Zein nano fiber porous film and preparation method

A nanofiber, zein technology, applied in medical science, prosthesis, etc., can solve the problems of expensive solvent and harmful environment, and achieve the effect of good biocompatibility, good permeability, and good clinical repair effect.

Inactive Publication Date: 2006-04-26
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Since general solvents cannot dissolve proteins, formic acid or fluorine-containing solvents are usually used as solvents to prepare protein nanofiber membrane materi

Method used

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  • Zein nano fiber porous film and preparation method
  • Zein nano fiber porous film and preparation method
  • Zein nano fiber porous film and preparation method

Examples

Experimental program
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Effect test

Example Embodiment

[0041] The preparation method of the zein nanofiber porous membrane is to dissolve zein in a solvent to obtain an electrospinning solution, or dissolve additives in the above solution to obtain an electrospinning mixture, add it to a storage tank, and connect to a Or multiple jetting heads, the jetting heads are connected to a DC high-voltage electric field, the voltage is positive or negative 3 kV-120 kV, the receiving device is grounded, and electrospinning is performed to obtain ribbon-shaped zein nanofibers, which are randomly stacked The zein nanofiber porous membrane is obtained, the lateral size of the nanofibers is 20 nanometers to 10 microns, and the pore size of the porous membrane is 100 nanometers to 100 microns. Alternatively, the obtained porous zein nanofiber membrane is soaked in a cross-linking agent solution, and the cross-linked zein nanofiber porous membrane is obtained after drying, and then soaked in the additive solution. The crosslinking agent is aldehyde, ...

Example Embodiment

[0045] Example 1

[0046] Dissolve 5g of zein in a mixed solvent of 10ml of ethanol and water, the volume ratio of ethanol to water is 70:30, make a 50% (w / v) polymer solution, then add it to the storage tank and pass the syringe pump The nozzle is connected to the jet head and the jet head is connected to the high-voltage positive electric field. The distance between the jet head and the receiver is controlled at about 10cm, the solution flow rate is 6ml / h, the voltage is 15kV, and the electrospinning is performed to obtain the nanofiber membrane material. Electron microscope observation (see attachment figure 1 ), the nanofiber is a ribbon structure, and the lateral size of the fiber is between 100 nanometers and 4 micrometers.

Example Embodiment

[0047] Example 2

[0048] Dissolve 3 grams of zein in a mixed solvent of 10ml of ethanol and water, the volume ratio of ethanol to water is 90:10, and make a 30% (w / v) polymer solution, then add it to the storage tank and pass the syringe pump The nozzle is connected to the jet head and the jet head is connected to a high-voltage positive electric field. The distance between the jet head and the receiver is controlled at about 10cm, the solution flow rate is 6ml / h, the voltage is 10kV, and electrospinning is performed to obtain ribbon-like structured nanofibers. The fibers are randomly stacked to form a zein nanofiber membrane.

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Abstract

The nanometer fiber porous membrane of corn protein is a functional fiber material, comprising: superfine fiber which can adsorb the natural high polymer corn protein or additive, the nanometer fiber of corn protein is ribbon-like fiber, the transverse size of the nanometer fiber is 20 nm- 10 um, the nanometer fiber of corn protein accumulates irregularly to form the nanometer fiber porous membrane, the pore size of the porous membrane is 100 nm - 100 um. The method for preparing the material which can adsorb the superfine fiber membrane with corn protein is: adding the corn protein to the mixed solvent of ethanol and water and getting the electrically weaved mixture, and then weaving electrically to get the material.

Description

technical field [0001] The invention relates to a zein nanofiber porous membrane and a preparation method thereof, belonging to the technical field of functional fiber membrane materials and their preparation. Background technique [0002] Tissue engineering scaffolds are key materials for cell and tissue culture, and proteins or protein-containing blends are commonly used scaffold materials, such as collagen, gelatin, silk fibroin, etc. [0003] Skin repair materials usually include membrane materials, mesh materials, and hydrogels. Membrane material has poor air permeability, which often leads to subcutaneous tissue accumulation and prolongs the tissue healing period; mesh material has good air permeability, allows cells to grow in, and has high strength. Due to the large pore size, it has no barrier effect on bacteria. Ordinary mesh materials and tissue It is difficult to separate, which brings pain to patients; hydrogel is a kind of skin repair material that has been us...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/60
Inventor 李新松姚琛浦跃朴李云晖宋唐英范凯红
Owner SOUTHEAST UNIV
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