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Process for preparing biological degradable tricalcium phosphate nano powder

A tricalcium phosphate nano and biodegradable technology, applied in nanostructure manufacturing, nanotechnology, nanotechnology and other directions, can solve the problems of high price and low phosphorus content, achieve high activity, simple preparation process, and easy control of process parameters. Effect

Inactive Publication Date: 2006-06-28
SICHUAN UNIV
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Problems solved by technology

[0003] Chinese Patent No. CN1557774A "Preparation Method of Calcium Phosphate Bioceramic Nanopowder" discloses a method of using calcium nitrate Ca(NO 3 ) 2 4H 2 O and trimethyl phosphate are used as raw materials to synthesize calcium phosphate-based bioceramic nanopowders including hydroxyapatite and β-tricalcium phosphate, but the raw material trimethyl phosphate is expensive compared with phosphorus pentoxide , and low phosphorus content

Method used

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  • Process for preparing biological degradable tricalcium phosphate nano powder
  • Process for preparing biological degradable tricalcium phosphate nano powder

Examples

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example 1

[0023] According to the Ca / P molar ratio is 1.50 to take the calculated amount of calcium nitrate Ca (NO 3 ) 2 4H 2 O49.4g and phosphorus pentoxide P 2 o 5 10g, after dissolving in 100ml of absolute ethanol, add 5g of dispersant citric acid to the above mixed alcohol solution; The wet gel was obtained by medium aging for 24 hours, and then dried in a vacuum oven at 80°C for 24 hours to obtain a dry gel; after the dry gel was ground, it was calcined at 930°C for 2 hours to obtain β-tricalcium phosphate nanopowder. Diffraction results such as Figure 1 shown.

example 2

[0025] Weigh the calculated amount of calcium nitrate Ca(NO 3 ) 2 4H 2 O247g and phosphorus pentoxide P 2 o 5 Dissolve 50g in 800ml of absolute ethanol, after fully dissolving and mixing uniformly, adjust the pH value to 6 with ammonia water, then age the uniformly mixed sol in a water bath at 70°C for 48 hours to obtain a wet gel, and then place it in a vacuum oven at 80°C Dry in medium for 24 hours to obtain xerogel; grind the xerogel finely and calcined at 850°C to obtain the desired nanopowder. Transmission results such as Figure II shown.

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Abstract

A process for preparing the biodegradable tricalcium phosphate nano-particles from Ca(NH3)2*4H2O and P2O5 includes such steps as dissolving in alcohol, adding disperser, adding ammonia water to regulate pH=3-11, stirring to obtain sol, ageing in water bath or oil bath at 50-80 deg.C for obtaining wet gel, drying, grinding and calcining.

Description

technical field [0001] The invention relates to a method for manufacturing nanometer tricalcium phosphate powder, which belongs to the field of fine chemical industry. Background technique [0002] Tricalcium phosphate biomaterials have good bioactivity, biocompatibility and biodegradability, and have been widely used in medicine and hard tissue replacement materials. For example, α-tricalcium phosphate can be used to prepare bone cement, and porous β- Tricalcium phosphate materials have been used as controllable drug slow-release carriers for antibiotic treatment of bone infections, and β-tricalcium phosphate dental adhesives combined with antibacterial agents can treat various types of dental caries; Ito et al. (A.ITO, K.OJIMA , H.NAITO, N.ICHINOSE and T.TATEISHI, J.Biomed.Mater.Res.50 (2000) 178.) found that β-tricalcium phosphate doped with a small amount of zinc has high cell activity and is beneficial to Proliferation of osteoblast MC3T3-E1. At present, many scientif...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82B3/00
Inventor 周大利尹光福黄智陈槐卿杨为中张云
Owner SICHUAN UNIV
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