Synthetic method for preparing 2-acyl 4-allcyl phenol

Abstract

The present invention relates to the synthesis process of different kinds of 2-acyl-4-alkyl phenol, which is the important intermediate of metal extractant 5-alkyl-2-hydroxyalkyl benzopheonone oxime. Through a two-step reaction under relatively mild condition, the present invention can obtain the target product in high yield and high selectivity, and the solvent, the reaction produced halohydrocarbon and the catalyst aqua may be reused without exhaust. The synthesis process has industrial production foreground obviously.

Description

technical field [0001] The invention belongs to the field of chemical materials and relates to a synthesis method for preparing 2-acyl-4-alkylphenol, an important precursor of a metal extractant. Background technique [0002] 2-acyl-4-alkylphenol (I) is an important intermediate of metal extractant 5-alkyl-2-hydroxyalkylphenone oxime (II), which can be obtained by reacting with hydroxylamine to obtain 5-alkyl-2 -Hydroxyalkylphenone oxime (II). This type of ketoxime is widely used in the field of metal extraction. For example: 2-acetyl-4-nonylphenol is an important precursor of extractants for copper, nickel and other metal purification (see: U.S. Pat. No. 5,300,689; U.S. Pat. No. 5,969,185; U.S. Pat. No. 5,488,161; WO.95 / 01957; J. Prakt. Chem. 1989, 331(4), 617-630). Its structural formula is as follows: [0003] [0004] In U.S.Pat.No.5,300,689 describes a method for preparing 2-acyl-4-alkylphenols with Fries rearrangement, the method has low yield, high reaction tem...

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Problems solved by technology

In order to overcome the problems of low total yield, harsh equipment requirements, severe reaction conditions, unstable process route, difficult product separation and purification and low product purity in the prior art

[0006] The advantages and innovations of the present invention are that ① avoiding the use of high temperature and relatively expensive reagents; ② overcoming the problems of complex operation, harsh reaction conditions, and difficulties in product separation and purification; ③ obtaining high yield and high selectivity under mild conditions. The target product; ④The purity of the product is higher than that obtained by other production methods. The purity of the 2-acyl-4-alkylphenol obtained by the method provided by the patent of the present invention can generally reach more than 90%, while the 2-acylphenol prepared by the traditional method The purity of -4-alkylphenol generally only has 80-85%; ⑤ most of the by-product chlorinated hydrocarbons produced by the reaction can be recovered, and catalysts, such as aqueous aluminum chloride solution, etc., can also be recycled well. The colorless aluminum chloride aqueous solution can be used to prepare polyaluminum chloride (referred to as PAC) without further decolorization and purification, and PAC is a new type of inorganic polymer coagulant, which has replaced Ferric chloride, aluminum sulfate, and alum are widely used ("Review of the production method of polyaluminum chloride", Henan Chemical Industry, 1994, 8)

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